ملخص
A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)32+] and peroxydisulphate (S2O82-) in the presence of light. The instrumental set-up utilized a syringe pump and a multiposition valve to aspirate the reagents [Ru(phen)32+ and S 2O82-] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 μg/ml were obtained. The detection limit was 0.04 μg/ml and the relative standard deviation (RSD) was always < 5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.
اللغة الأصلية | English |
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الصفحات (من إلى) | 2-9 |
عدد الصفحات | 8 |
دورية | Luminescence |
مستوى الصوت | 24 |
رقم الإصدار | 1 |
المعرِّفات الرقمية للأشياء | |
حالة النشر | Published - 2009 |
ASJC Scopus subject areas
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