Chemiluminescence determination of chlorpheniramine using tris(1,10- Phenanthroline)-ruthenium(II) peroxydisulphate system and sequential injection analysis

Fakhr Eldin O Suliman, Mohammed M. Al-Hinai, Salma M Z Al-Kindy, Salama B. Salama

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)3 2+] and peroxydisulphate (S2O8 2-) in the presence of light. The instrumental set-up utilized a syringe pump and a multiposition valve to aspirate the reagents [Ru(phen)3 2+ and S 2O8 2-] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 μg/ml were obtained. The detection limit was 0.04 μg/ml and the relative standard deviation (RSD) was always <5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

Original languageEnglish
Pages (from-to)2-9
Number of pages8
JournalLuminescence
Volume24
Issue number1
DOIs
Publication statusPublished - Jan 2009

Fingerprint

Chlorpheniramine
Chemiluminescence
Luminescence
Pumps
Syringes
Injections
Pharmaceutical Preparations
Calibration
Limit of Detection
Light
tris-(1,10-phenanthroline)ruthenium

Keywords

  • Chemiluminescence
  • Chlorpheniramine
  • Peroxydisulphate
  • Tris(1,10-phenanthroline)-ruthenium(ii)

ASJC Scopus subject areas

  • Biophysics
  • Chemistry (miscellaneous)

Cite this

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title = "Chemiluminescence determination of chlorpheniramine using tris(1,10- Phenanthroline)-ruthenium(II) peroxydisulphate system and sequential injection analysis",
abstract = "A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)3 2+] and peroxydisulphate (S2O8 2-) in the presence of light. The instrumental set-up utilized a syringe pump and a multiposition valve to aspirate the reagents [Ru(phen)3 2+ and S 2O8 2-] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 μg/ml were obtained. The detection limit was 0.04 μg/ml and the relative standard deviation (RSD) was always <5{\%}. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.",
keywords = "Chemiluminescence, Chlorpheniramine, Peroxydisulphate, Tris(1,10-phenanthroline)-ruthenium(ii)",
author = "Suliman, {Fakhr Eldin O} and Al-Hinai, {Mohammed M.} and Al-Kindy, {Salma M Z} and Salama, {Salama B.}",
year = "2009",
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T1 - Chemiluminescence determination of chlorpheniramine using tris(1,10- Phenanthroline)-ruthenium(II) peroxydisulphate system and sequential injection analysis

AU - Suliman, Fakhr Eldin O

AU - Al-Hinai, Mohammed M.

AU - Al-Kindy, Salma M Z

AU - Salama, Salama B.

PY - 2009/1

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N2 - A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)3 2+] and peroxydisulphate (S2O8 2-) in the presence of light. The instrumental set-up utilized a syringe pump and a multiposition valve to aspirate the reagents [Ru(phen)3 2+ and S 2O8 2-] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 μg/ml were obtained. The detection limit was 0.04 μg/ml and the relative standard deviation (RSD) was always <5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

AB - A sequential injection (SI) method was developed for the determination of chlorpheniramine (CPA), based on the reaction of this drug with tris(1,10-phenanthroline)-ruthenium(II) [Ru(phen)3 2+] and peroxydisulphate (S2O8 2-) in the presence of light. The instrumental set-up utilized a syringe pump and a multiposition valve to aspirate the reagents [Ru(phen)3 2+ and S 2O8 2-] and a peristaltic pump to propel the sample. The experimental conditions affecting the chemiluminescence reaction were systematically optimized, using the univariate approach. Under the optimum conditions linear calibration curves of 0.1-10 μg/ml were obtained. The detection limit was 0.04 μg/ml and the relative standard deviation (RSD) was always <5%. The procedure was applied to the analysis of CPA in pharmaceutical products and was found to be free from interferences from concomitants usually present in these preparations.

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KW - Tris(1,10-phenanthroline)-ruthenium(ii)

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