Association of the risk allele of dopamine transporter gene (DAT1*10) in Omani male children with attention-deficit hyperactivity disorder

Mehmet Simsek*, Marwan Al-Sharbati, Samir Al-Adawi, Shyam S. Ganguly, Kholuud Lawatia

*المؤلف المقابل لهذا العمل

نتاج البحث: المساهمة في مجلةمراجعة النظراء

20 اقتباسات (Scopus)

ملخص

Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD). Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis. Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and*10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%).

اللغة الأصليةEnglish
الصفحات (من إلى)739-742
عدد الصفحات4
دوريةClinical Biochemistry
مستوى الصوت38
رقم الإصدار8
المعرِّفات الرقمية للأشياء
حالة النشرPublished - أغسطس 2005

ASJC Scopus subject areas

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بصمة

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