Abstract
Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD). Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis. Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and*10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%).
| Original language | English |
|---|---|
| Pages (from-to) | 739-742 |
| Number of pages | 4 |
| Journal | Clinical Biochemistry |
| Volume | 38 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Aug 2005 |
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Keywords
- ADHD
- Attention-deficit hyperactivity disorder
- DAT1
- Dopamine transporter gene
- Polymorphism
- VNTR
ASJC Scopus subject areas
- Clinical Biochemistry
Cite this
Association of the risk allele of dopamine transporter gene (DAT1*10) in Omani male children with attention-deficit hyperactivity disorder. / Simsek, Mehmet; Al-Sharbati, Marwan; Al-Adawi, Samir; Ganguly, Shyam S.; Lawatia, Kholuud.
In: Clinical Biochemistry, Vol. 38, No. 8, 08.2005, p. 739-742.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Association of the risk allele of dopamine transporter gene (DAT1*10) in Omani male children with attention-deficit hyperactivity disorder
AU - Simsek, Mehmet
AU - Al-Sharbati, Marwan
AU - Al-Adawi, Samir
AU - Ganguly, Shyam S.
AU - Lawatia, Kholuud
PY - 2005/8
Y1 - 2005/8
N2 - Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD). Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis. Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and*10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%).
AB - Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD). Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis. Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and*10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%).
KW - ADHD
KW - Attention-deficit hyperactivity disorder
KW - DAT1
KW - Dopamine transporter gene
KW - Polymorphism
KW - VNTR
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UR - http://www.scopus.com/inward/citedby.url?scp=22544486320&partnerID=8YFLogxK
U2 - 10.1016/j.clinbiochem.2005.04.016
DO - 10.1016/j.clinbiochem.2005.04.016
M3 - Article
VL - 38
SP - 739
EP - 742
JO - Clinical Biochemistry
JF - Clinical Biochemistry
SN - 0009-9120
IS - 8
ER -