Association of the risk allele of dopamine transporter gene (DAT1*10) in Omani male children with attention-deficit hyperactivity disorder

Mehmet Simsek, Marwan Al-Sharbati, Samir Al-Adawi, Shyam S. Ganguly, Kholuud Lawatia

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

Objectives: To determine the frequency of the VNTR alleles in the human dopamine transporter gene (DAT1) in the Omani population and to investigate association of the VNTR alleles with attention-deficit hyperactivity disorder (ADHD). Design and methods: 92 Omani children with ADHD and 110 healthy Omani subjects were genotyped for the DAT1-VNTR polymorphism in a case-control study using two independent PCR tests (one developed in our laboratory) followed by agarose gel electrophoresis. Results and conclusions: We determined the DAT1-VNTR alleles in 202 Omani subjects. There were two common alleles (DAT1*9 and*10) and five rare ones. The DAT1*10 allele distribution was essentially the same both in the control (60.9%) and the patient group (64.6%). There was, however, a relatively higher occurrence of the DAT1*10 allele in ADHD males (69.4%) than females (55%), but this gender difference was not present in the control group (males 60%, females 62%).

Original languageEnglish
Pages (from-to)739-742
Number of pages4
JournalClinical Biochemistry
Volume38
Issue number8
DOIs
Publication statusPublished - Aug 2005

Keywords

  • ADHD
  • Attention-deficit hyperactivity disorder
  • DAT1
  • Dopamine transporter gene
  • Polymorphism
  • VNTR

ASJC Scopus subject areas

  • Clinical Biochemistry

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