Wilson's disease: Cranial MRI observations and clinical correlation

Sanjib Sinha, A. B. Taly, S. Ravishankar, L. K. Prashanth, K. S. Venugopal, G. R. Arunodaya, M. K. Vasudev, H. S. Swamy

Research output: Contribution to journalArticle

145 Citations (Scopus)

Abstract

Introduction: Study of MRI changes may be useful in diagnosis, prognosis and better understanding of the pathophysiology of Wilson's disease (WD). We aimed to describe and correlate the MRI abnormalities of the brain with clinical features in WD. Methods: MRI evaluation was carried out in 100 patients (57 males, 43 females; mean age 19.3±8.9 years) using standard protocols. All but 18 patients were on de-coppering agents. Their history, clinical manifestations and scores for severity of disease were noted. Results: The mean duration of illness and treatment were 8.3±10.8 years and 7.5±7.1 years respectively. MRI of the brain was abnormal in all the 93 symptomatic patients. The most conspicuous observations were atrophy of the cerebrum (70%), brainstem (66%) and cerebellum (52%). Signal abnormalities were also noted: putamen (72%), caudate (61%), thalami (58%), midbrain (49%), pons (20%), cerebral white matter (25%), cortex (9%), medulla (12%) and cerebellum (10%). The characteristic T2-W globus pallidal hypointensity (34%), "Face of giant panda" sign (12%), T1-W striatal hyperintensity (6%), central pontine myelinosis (7%), and bright claustral sign (4%) were also detected. MRI changes correlated with disease severity scores (P

Original languageEnglish
Pages (from-to)613-621
Number of pages9
JournalNeuroradiology
Volume48
Issue number9
DOIs
Publication statusPublished - Sep 2006

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Hepatolenticular Degeneration
Cerebellum
Ursidae
Corpus Striatum
Pons
Putamen
Brain
Cerebrum
Mesencephalon
Thalamus
Brain Stem
Atrophy
History
Therapeutics

Keywords

  • MRI
  • Wilson's disease

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Clinical Neurology
  • Radiological and Ultrasound Technology

Cite this

Sinha, S., Taly, A. B., Ravishankar, S., Prashanth, L. K., Venugopal, K. S., Arunodaya, G. R., ... Swamy, H. S. (2006). Wilson's disease: Cranial MRI observations and clinical correlation. Neuroradiology, 48(9), 613-621. https://doi.org/10.1007/s00234-006-0101-4

Wilson's disease : Cranial MRI observations and clinical correlation. / Sinha, Sanjib; Taly, A. B.; Ravishankar, S.; Prashanth, L. K.; Venugopal, K. S.; Arunodaya, G. R.; Vasudev, M. K.; Swamy, H. S.

In: Neuroradiology, Vol. 48, No. 9, 09.2006, p. 613-621.

Research output: Contribution to journalArticle

Sinha, S, Taly, AB, Ravishankar, S, Prashanth, LK, Venugopal, KS, Arunodaya, GR, Vasudev, MK & Swamy, HS 2006, 'Wilson's disease: Cranial MRI observations and clinical correlation', Neuroradiology, vol. 48, no. 9, pp. 613-621. https://doi.org/10.1007/s00234-006-0101-4
Sinha S, Taly AB, Ravishankar S, Prashanth LK, Venugopal KS, Arunodaya GR et al. Wilson's disease: Cranial MRI observations and clinical correlation. Neuroradiology. 2006 Sep;48(9):613-621. https://doi.org/10.1007/s00234-006-0101-4
Sinha, Sanjib ; Taly, A. B. ; Ravishankar, S. ; Prashanth, L. K. ; Venugopal, K. S. ; Arunodaya, G. R. ; Vasudev, M. K. ; Swamy, H. S. / Wilson's disease : Cranial MRI observations and clinical correlation. In: Neuroradiology. 2006 ; Vol. 48, No. 9. pp. 613-621.
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