Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One

M. Innes Asher, Alistair W. Stewart, Javier Mallol, Stephen Montefort, Christopher K W Lai, Nadia Aït-Khaled, Joseph Odhiambo, G. Anabwani, H. R. Anderson, M. I. Asher, T. O. Clayton, P. Ellwood, E. A. Mitchell, R. Beasley, B. Björkstén, M. L. Burr, J. Crane, U. Keil, F. Martinez, N. Pearce & 139 others C. F. Robertson, J. R. Shah, B. Sibbald, D. P. Strachan, E. von Mutius, S. K. Weiland, H. C. Williams, A. Bezzaoucha, K. Melaku, B. Seyoum, F. O. Esamai, B. O. Onadeko, H. Nelson, Y. Z. Chen, K. H. Chen, N. S. Zhong, M. Bao-Shan, M. L. Xiao, Y. L. Lau, K. Baratawidjaja, S. Nishima, K. H. Teh, L. W. Yeong, J. de Bruyne, B. S. Quah, K. W. Chum, F. Cua-Lim, S. I. Lee, B. W. Lee, K. H. Hsieh, P. Vichyanond, M. Trakultivakorn, M. R. Masjedi, J. A. al-Momen, F. M. Ramadan, B. M S Al Riyami, Z. Bouayad, A. Bennis, Z. A. Bhutta, N. Salmun, N. Rosário, R. Stein, P. G M Bezerra, L. deFreitas Souza, D. Solé, I. Sanchez, L. Amarales, E. Cortez, M. A. Calvo, C. Soto-Quirós, I. Romieu, G. Cukier, J. A. Guggiari-Chase, P. Chiarella, D. Holgado, M. R. Sears, B. Taylor, V. Persky, G. J. Redding, D. Jeffs, C. R. Grainger, A. Priftanji, M. A. Riikjärv, M. Kajosaari, J. Pekkanen, L. Soininen, T. A. Koivikko, N. Khetsuriani, A. Gamkrelidze, M. Leja, G. Lis, A. Brêborowicz, D. Dumitrascu, R. M. Khaitov, N. I. Kjellman, T. Foucard, T. Aripova, D. Kennedy, L. Landau, J. Peat, A. Bauman, C. Moyes, P. Pattemore, D. Barry, R. Mackay, R. M. Maheshwari, M. K. Joshi, U. A. Pai, K. Raghavan, V. A. Khatav, L. Kumar, K. C. Jain, T. U. Sukumaran, S. Rajajee, N. Somu, K. Chopra, G. Jayaraj, P. K. Kar, N. M. Hanumante, J. Riedler, G. Haidinger, P. Vermeire, D. Charpin, P. Godard, A. Taytard, C. Kopferschmitt, I. Annesi-Maesano, A. Kramer, C. Gratziou, P. V. Powell, S. Bonini, E. Bonci, F. Rusconi, M. Biocca, L. Chetoni, E. Chellini, R. Ronchetti, L. Bisanti, F. Forastiere, E. Renzoni, G. Ciccone, S. Piffer, A. Boner, G. Corbo, F. D. Borges, J. E. Rosado Pinto, C. Nunes, J. M. Lopesdos Santos, L. Clancy, R. M. Busquets, A. D. Rubio, A. R. Asensio, L. García-Marcos, A. Arnedo-Pena, F. Guillén-Grima, M. M. Morales-Suárez-Varela, A. Blanco Quirós, M. H. Shamssain, D. Strachan

Research output: Contribution to journalReview article

72 Citations (Scopus)

Abstract

The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution.Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence.The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.

Original languageEnglish
Article number8
JournalRespiratory Research
Volume11
DOIs
Publication statusPublished - Jan 21 2010

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Eczema
Hypersensitivity
Asthma
Population
Air Pollution
Acetaminophen
Pollen
Immunization
Tuberculosis
Smoking
Gross Domestic Product
Anti-Bacterial Agents
Trans Fatty Acids
Edible Plants
Tobacco Use
Insurance Benefits
Climate
Causality
Public Health
Eating

ASJC Scopus subject areas

  • Pulmonary and Respiratory Medicine

Cite this

Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. / Innes Asher, M.; Stewart, Alistair W.; Mallol, Javier; Montefort, Stephen; Lai, Christopher K W; Aït-Khaled, Nadia; Odhiambo, Joseph; Anabwani, G.; Anderson, H. R.; Asher, M. I.; Clayton, T. O.; Ellwood, P.; Mitchell, E. A.; Beasley, R.; Björkstén, B.; Burr, M. L.; Crane, J.; Keil, U.; Martinez, F.; Pearce, N.; Robertson, C. F.; Shah, J. R.; Sibbald, B.; Strachan, D. P.; von Mutius, E.; Weiland, S. K.; Williams, H. C.; Bezzaoucha, A.; Melaku, K.; Seyoum, B.; Esamai, F. O.; Onadeko, B. O.; Nelson, H.; Chen, Y. Z.; Chen, K. H.; Zhong, N. S.; Bao-Shan, M.; Xiao, M. L.; Lau, Y. L.; Baratawidjaja, K.; Nishima, S.; Teh, K. H.; Yeong, L. W.; de Bruyne, J.; Quah, B. S.; Chum, K. W.; Cua-Lim, F.; Lee, S. I.; Lee, B. W.; Hsieh, K. H.; Vichyanond, P.; Trakultivakorn, M.; Masjedi, M. R.; al-Momen, J. A.; Ramadan, F. M.; Al Riyami, B. M S; Bouayad, Z.; Bennis, A.; Bhutta, Z. A.; Salmun, N.; Rosário, N.; Stein, R.; Bezerra, P. G M; deFreitas Souza, L.; Solé, D.; Sanchez, I.; Amarales, L.; Cortez, E.; Calvo, M. A.; Soto-Quirós, C.; Romieu, I.; Cukier, G.; Guggiari-Chase, J. A.; Chiarella, P.; Holgado, D.; Sears, M. R.; Taylor, B.; Persky, V.; Redding, G. J.; Jeffs, D.; Grainger, C. R.; Priftanji, A.; Riikjärv, M. A.; Kajosaari, M.; Pekkanen, J.; Soininen, L.; Koivikko, T. A.; Khetsuriani, N.; Gamkrelidze, A.; Leja, M.; Lis, G.; Brêborowicz, A.; Dumitrascu, D.; Khaitov, R. M.; Kjellman, N. I.; Foucard, T.; Aripova, T.; Kennedy, D.; Landau, L.; Peat, J.; Bauman, A.; Moyes, C.; Pattemore, P.; Barry, D.; Mackay, R.; Maheshwari, R. M.; Joshi, M. K.; Pai, U. A.; Raghavan, K.; Khatav, V. A.; Kumar, L.; Jain, K. C.; Sukumaran, T. U.; Rajajee, S.; Somu, N.; Chopra, K.; Jayaraj, G.; Kar, P. K.; Hanumante, N. M.; Riedler, J.; Haidinger, G.; Vermeire, P.; Charpin, D.; Godard, P.; Taytard, A.; Kopferschmitt, C.; Annesi-Maesano, I.; Kramer, A.; Gratziou, C.; Powell, P. V.; Bonini, S.; Bonci, E.; Rusconi, F.; Biocca, M.; Chetoni, L.; Chellini, E.; Ronchetti, R.; Bisanti, L.; Forastiere, F.; Renzoni, E.; Ciccone, G.; Piffer, S.; Boner, A.; Corbo, G.; Borges, F. D.; Rosado Pinto, J. E.; Nunes, C.; Lopesdos Santos, J. M.; Clancy, L.; Busquets, R. M.; Rubio, A. D.; Asensio, A. R.; García-Marcos, L.; Arnedo-Pena, A.; Guillén-Grima, F.; Morales-Suárez-Varela, M. M.; Blanco Quirós, A.; Shamssain, M. H.; Strachan, D.

In: Respiratory Research, Vol. 11, 8, 21.01.2010.

Research output: Contribution to journalReview article

Innes Asher, M, Stewart, AW, Mallol, J, Montefort, S, Lai, CKW, Aït-Khaled, N, Odhiambo, J, Anabwani, G, Anderson, HR, Asher, MI, Clayton, TO, Ellwood, P, Mitchell, EA, Beasley, R, Björkstén, B, Burr, ML, Crane, J, Keil, U, Martinez, F, Pearce, N, Robertson, CF, Shah, JR, Sibbald, B, Strachan, DP, von Mutius, E, Weiland, SK, Williams, HC, Bezzaoucha, A, Melaku, K, Seyoum, B, Esamai, FO, Onadeko, BO, Nelson, H, Chen, YZ, Chen, KH, Zhong, NS, Bao-Shan, M, Xiao, ML, Lau, YL, Baratawidjaja, K, Nishima, S, Teh, KH, Yeong, LW, de Bruyne, J, Quah, BS, Chum, KW, Cua-Lim, F, Lee, SI, Lee, BW, Hsieh, KH, Vichyanond, P, Trakultivakorn, M, Masjedi, MR, al-Momen, JA, Ramadan, FM, Al Riyami, BMS, Bouayad, Z, Bennis, A, Bhutta, ZA, Salmun, N, Rosário, N, Stein, R, Bezerra, PGM, deFreitas Souza, L, Solé, D, Sanchez, I, Amarales, L, Cortez, E, Calvo, MA, Soto-Quirós, C, Romieu, I, Cukier, G, Guggiari-Chase, JA, Chiarella, P, Holgado, D, Sears, MR, Taylor, B, Persky, V, Redding, GJ, Jeffs, D, Grainger, CR, Priftanji, A, Riikjärv, MA, Kajosaari, M, Pekkanen, J, Soininen, L, Koivikko, TA, Khetsuriani, N, Gamkrelidze, A, Leja, M, Lis, G, Brêborowicz, A, Dumitrascu, D, Khaitov, RM, Kjellman, NI, Foucard, T, Aripova, T, Kennedy, D, Landau, L, Peat, J, Bauman, A, Moyes, C, Pattemore, P, Barry, D, Mackay, R, Maheshwari, RM, Joshi, MK, Pai, UA, Raghavan, K, Khatav, VA, Kumar, L, Jain, KC, Sukumaran, TU, Rajajee, S, Somu, N, Chopra, K, Jayaraj, G, Kar, PK, Hanumante, NM, Riedler, J, Haidinger, G, Vermeire, P, Charpin, D, Godard, P, Taytard, A, Kopferschmitt, C, Annesi-Maesano, I, Kramer, A, Gratziou, C, Powell, PV, Bonini, S, Bonci, E, Rusconi, F, Biocca, M, Chetoni, L, Chellini, E, Ronchetti, R, Bisanti, L, Forastiere, F, Renzoni, E, Ciccone, G, Piffer, S, Boner, A, Corbo, G, Borges, FD, Rosado Pinto, JE, Nunes, C, Lopesdos Santos, JM, Clancy, L, Busquets, RM, Rubio, AD, Asensio, AR, García-Marcos, L, Arnedo-Pena, A, Guillén-Grima, F, Morales-Suárez-Varela, MM, Blanco Quirós, A, Shamssain, MH & Strachan, D 2010, 'Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One', Respiratory Research, vol. 11, 8. https://doi.org/10.1186/1465-9921-11-8
Innes Asher, M. ; Stewart, Alistair W. ; Mallol, Javier ; Montefort, Stephen ; Lai, Christopher K W ; Aït-Khaled, Nadia ; Odhiambo, Joseph ; Anabwani, G. ; Anderson, H. R. ; Asher, M. I. ; Clayton, T. O. ; Ellwood, P. ; Mitchell, E. A. ; Beasley, R. ; Björkstén, B. ; Burr, M. L. ; Crane, J. ; Keil, U. ; Martinez, F. ; Pearce, N. ; Robertson, C. F. ; Shah, J. R. ; Sibbald, B. ; Strachan, D. P. ; von Mutius, E. ; Weiland, S. K. ; Williams, H. C. ; Bezzaoucha, A. ; Melaku, K. ; Seyoum, B. ; Esamai, F. O. ; Onadeko, B. O. ; Nelson, H. ; Chen, Y. Z. ; Chen, K. H. ; Zhong, N. S. ; Bao-Shan, M. ; Xiao, M. L. ; Lau, Y. L. ; Baratawidjaja, K. ; Nishima, S. ; Teh, K. H. ; Yeong, L. W. ; de Bruyne, J. ; Quah, B. S. ; Chum, K. W. ; Cua-Lim, F. ; Lee, S. I. ; Lee, B. W. ; Hsieh, K. H. ; Vichyanond, P. ; Trakultivakorn, M. ; Masjedi, M. R. ; al-Momen, J. A. ; Ramadan, F. M. ; Al Riyami, B. M S ; Bouayad, Z. ; Bennis, A. ; Bhutta, Z. A. ; Salmun, N. ; Rosário, N. ; Stein, R. ; Bezerra, P. G M ; deFreitas Souza, L. ; Solé, D. ; Sanchez, I. ; Amarales, L. ; Cortez, E. ; Calvo, M. A. ; Soto-Quirós, C. ; Romieu, I. ; Cukier, G. ; Guggiari-Chase, J. A. ; Chiarella, P. ; Holgado, D. ; Sears, M. R. ; Taylor, B. ; Persky, V. ; Redding, G. J. ; Jeffs, D. ; Grainger, C. R. ; Priftanji, A. ; Riikjärv, M. A. ; Kajosaari, M. ; Pekkanen, J. ; Soininen, L. ; Koivikko, T. A. ; Khetsuriani, N. ; Gamkrelidze, A. ; Leja, M. ; Lis, G. ; Brêborowicz, A. ; Dumitrascu, D. ; Khaitov, R. M. ; Kjellman, N. I. ; Foucard, T. ; Aripova, T. ; Kennedy, D. ; Landau, L. ; Peat, J. ; Bauman, A. ; Moyes, C. ; Pattemore, P. ; Barry, D. ; Mackay, R. ; Maheshwari, R. M. ; Joshi, M. K. ; Pai, U. A. ; Raghavan, K. ; Khatav, V. A. ; Kumar, L. ; Jain, K. C. ; Sukumaran, T. U. ; Rajajee, S. ; Somu, N. ; Chopra, K. ; Jayaraj, G. ; Kar, P. K. ; Hanumante, N. M. ; Riedler, J. ; Haidinger, G. ; Vermeire, P. ; Charpin, D. ; Godard, P. ; Taytard, A. ; Kopferschmitt, C. ; Annesi-Maesano, I. ; Kramer, A. ; Gratziou, C. ; Powell, P. V. ; Bonini, S. ; Bonci, E. ; Rusconi, F. ; Biocca, M. ; Chetoni, L. ; Chellini, E. ; Ronchetti, R. ; Bisanti, L. ; Forastiere, F. ; Renzoni, E. ; Ciccone, G. ; Piffer, S. ; Boner, A. ; Corbo, G. ; Borges, F. D. ; Rosado Pinto, J. E. ; Nunes, C. ; Lopesdos Santos, J. M. ; Clancy, L. ; Busquets, R. M. ; Rubio, A. D. ; Asensio, A. R. ; García-Marcos, L. ; Arnedo-Pena, A. ; Guillén-Grima, F. ; Morales-Suárez-Varela, M. M. ; Blanco Quirós, A. ; Shamssain, M. H. ; Strachan, D. / Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One. In: Respiratory Research. 2010 ; Vol. 11.
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title = "Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One",
abstract = "The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution.Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence.The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.",
author = "{Innes Asher}, M. and Stewart, {Alistair W.} and Javier Mallol and Stephen Montefort and Lai, {Christopher K W} and Nadia A{\"i}t-Khaled and Joseph Odhiambo and G. Anabwani and Anderson, {H. R.} and Asher, {M. I.} and Clayton, {T. O.} and P. Ellwood and Mitchell, {E. A.} and R. Beasley and B. Bj{\"o}rkst{\'e}n and Burr, {M. L.} and J. Crane and U. Keil and F. Martinez and N. Pearce and Robertson, {C. F.} and Shah, {J. R.} and B. Sibbald and Strachan, {D. P.} and {von Mutius}, E. and Weiland, {S. K.} and Williams, {H. C.} and A. Bezzaoucha and K. Melaku and B. Seyoum and Esamai, {F. O.} and Onadeko, {B. O.} and H. Nelson and Chen, {Y. Z.} and Chen, {K. H.} and Zhong, {N. S.} and M. Bao-Shan and Xiao, {M. L.} and Lau, {Y. L.} and K. Baratawidjaja and S. Nishima and Teh, {K. H.} and Yeong, {L. W.} and {de Bruyne}, J. and Quah, {B. S.} and Chum, {K. W.} and F. Cua-Lim and Lee, {S. I.} and Lee, {B. W.} and Hsieh, {K. H.} and P. Vichyanond and M. Trakultivakorn and Masjedi, {M. R.} and al-Momen, {J. A.} and Ramadan, {F. M.} and {Al Riyami}, {B. M S} and Z. Bouayad and A. Bennis and Bhutta, {Z. A.} and N. Salmun and N. Ros{\'a}rio and R. Stein and Bezerra, {P. G M} and {deFreitas Souza}, L. and D. Sol{\'e} and I. Sanchez and L. Amarales and E. Cortez and Calvo, {M. A.} and C. Soto-Quir{\'o}s and I. Romieu and G. Cukier and Guggiari-Chase, {J. A.} and P. Chiarella and D. Holgado and Sears, {M. R.} and B. Taylor and V. Persky and Redding, {G. J.} and D. Jeffs and Grainger, {C. R.} and A. Priftanji and Riikj{\"a}rv, {M. A.} and M. Kajosaari and J. Pekkanen and L. Soininen and Koivikko, {T. A.} and N. Khetsuriani and A. Gamkrelidze and M. Leja and G. Lis and A. Br{\^e}borowicz and D. Dumitrascu and Khaitov, {R. M.} and Kjellman, {N. I.} and T. Foucard and T. Aripova and D. Kennedy and L. Landau and J. Peat and A. Bauman and C. Moyes and P. Pattemore and D. Barry and R. Mackay and Maheshwari, {R. M.} and Joshi, {M. K.} and Pai, {U. A.} and K. Raghavan and Khatav, {V. A.} and L. Kumar and Jain, {K. C.} and Sukumaran, {T. U.} and S. Rajajee and N. Somu and K. Chopra and G. Jayaraj and Kar, {P. K.} and Hanumante, {N. M.} and J. Riedler and G. Haidinger and P. Vermeire and D. Charpin and P. Godard and A. Taytard and C. Kopferschmitt and I. Annesi-Maesano and A. Kramer and C. Gratziou and Powell, {P. V.} and S. Bonini and E. Bonci and F. Rusconi and M. Biocca and L. Chetoni and E. Chellini and R. Ronchetti and L. Bisanti and F. Forastiere and E. Renzoni and G. Ciccone and S. Piffer and A. Boner and G. Corbo and Borges, {F. D.} and {Rosado Pinto}, {J. E.} and C. Nunes and {Lopesdos Santos}, {J. M.} and L. Clancy and Busquets, {R. M.} and Rubio, {A. D.} and Asensio, {A. R.} and L. Garc{\'i}a-Marcos and A. Arnedo-Pena and F. Guill{\'e}n-Grima and Morales-Su{\'a}rez-Varela, {M. M.} and {Blanco Quir{\'o}s}, A. and Shamssain, {M. H.} and D. Strachan",
year = "2010",
month = "1",
day = "21",
doi = "10.1186/1465-9921-11-8",
language = "English",
volume = "11",
journal = "Respiratory Research",
issn = "1465-9921",
publisher = "BioMed Central",

}

TY - JOUR

T1 - Which population level environmental factors are associated with asthma, rhinoconjunctivitis and eczema? Review of the ecological analyses of ISAAC Phase One

AU - Innes Asher, M.

AU - Stewart, Alistair W.

AU - Mallol, Javier

AU - Montefort, Stephen

AU - Lai, Christopher K W

AU - Aït-Khaled, Nadia

AU - Odhiambo, Joseph

AU - Anabwani, G.

AU - Anderson, H. R.

AU - Asher, M. I.

AU - Clayton, T. O.

AU - Ellwood, P.

AU - Mitchell, E. A.

AU - Beasley, R.

AU - Björkstén, B.

AU - Burr, M. L.

AU - Crane, J.

AU - Keil, U.

AU - Martinez, F.

AU - Pearce, N.

AU - Robertson, C. F.

AU - Shah, J. R.

AU - Sibbald, B.

AU - Strachan, D. P.

AU - von Mutius, E.

AU - Weiland, S. K.

AU - Williams, H. C.

AU - Bezzaoucha, A.

AU - Melaku, K.

AU - Seyoum, B.

AU - Esamai, F. O.

AU - Onadeko, B. O.

AU - Nelson, H.

AU - Chen, Y. Z.

AU - Chen, K. H.

AU - Zhong, N. S.

AU - Bao-Shan, M.

AU - Xiao, M. L.

AU - Lau, Y. L.

AU - Baratawidjaja, K.

AU - Nishima, S.

AU - Teh, K. H.

AU - Yeong, L. W.

AU - de Bruyne, J.

AU - Quah, B. S.

AU - Chum, K. W.

AU - Cua-Lim, F.

AU - Lee, S. I.

AU - Lee, B. W.

AU - Hsieh, K. H.

AU - Vichyanond, P.

AU - Trakultivakorn, M.

AU - Masjedi, M. R.

AU - al-Momen, J. A.

AU - Ramadan, F. M.

AU - Al Riyami, B. M S

AU - Bouayad, Z.

AU - Bennis, A.

AU - Bhutta, Z. A.

AU - Salmun, N.

AU - Rosário, N.

AU - Stein, R.

AU - Bezerra, P. G M

AU - deFreitas Souza, L.

AU - Solé, D.

AU - Sanchez, I.

AU - Amarales, L.

AU - Cortez, E.

AU - Calvo, M. A.

AU - Soto-Quirós, C.

AU - Romieu, I.

AU - Cukier, G.

AU - Guggiari-Chase, J. A.

AU - Chiarella, P.

AU - Holgado, D.

AU - Sears, M. R.

AU - Taylor, B.

AU - Persky, V.

AU - Redding, G. J.

AU - Jeffs, D.

AU - Grainger, C. R.

AU - Priftanji, A.

AU - Riikjärv, M. A.

AU - Kajosaari, M.

AU - Pekkanen, J.

AU - Soininen, L.

AU - Koivikko, T. A.

AU - Khetsuriani, N.

AU - Gamkrelidze, A.

AU - Leja, M.

AU - Lis, G.

AU - Brêborowicz, A.

AU - Dumitrascu, D.

AU - Khaitov, R. M.

AU - Kjellman, N. I.

AU - Foucard, T.

AU - Aripova, T.

AU - Kennedy, D.

AU - Landau, L.

AU - Peat, J.

AU - Bauman, A.

AU - Moyes, C.

AU - Pattemore, P.

AU - Barry, D.

AU - Mackay, R.

AU - Maheshwari, R. M.

AU - Joshi, M. K.

AU - Pai, U. A.

AU - Raghavan, K.

AU - Khatav, V. A.

AU - Kumar, L.

AU - Jain, K. C.

AU - Sukumaran, T. U.

AU - Rajajee, S.

AU - Somu, N.

AU - Chopra, K.

AU - Jayaraj, G.

AU - Kar, P. K.

AU - Hanumante, N. M.

AU - Riedler, J.

AU - Haidinger, G.

AU - Vermeire, P.

AU - Charpin, D.

AU - Godard, P.

AU - Taytard, A.

AU - Kopferschmitt, C.

AU - Annesi-Maesano, I.

AU - Kramer, A.

AU - Gratziou, C.

AU - Powell, P. V.

AU - Bonini, S.

AU - Bonci, E.

AU - Rusconi, F.

AU - Biocca, M.

AU - Chetoni, L.

AU - Chellini, E.

AU - Ronchetti, R.

AU - Bisanti, L.

AU - Forastiere, F.

AU - Renzoni, E.

AU - Ciccone, G.

AU - Piffer, S.

AU - Boner, A.

AU - Corbo, G.

AU - Borges, F. D.

AU - Rosado Pinto, J. E.

AU - Nunes, C.

AU - Lopesdos Santos, J. M.

AU - Clancy, L.

AU - Busquets, R. M.

AU - Rubio, A. D.

AU - Asensio, A. R.

AU - García-Marcos, L.

AU - Arnedo-Pena, A.

AU - Guillén-Grima, F.

AU - Morales-Suárez-Varela, M. M.

AU - Blanco Quirós, A.

AU - Shamssain, M. H.

AU - Strachan, D.

PY - 2010/1/21

Y1 - 2010/1/21

N2 - The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution.Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence.The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.

AB - The International Study of Asthma and Allergies in Childhood (ISAAC) Phase One showed large worldwide variations in the prevalence of symptoms of asthma, rhinoconjunctivitis and eczema, up to 10 to 20 fold between countries. Ecological analyses were undertaken with ISAAC Phase One data to explore factors that may have contributed to these variations, and are summarised and reviewed here. In ISAAC Phase One the prevalence of symptoms in the past 12 months of asthma, rhinoconjunctivitis and eczema were estimated from studies in 463,801 children aged 13 - 14 years in 155 centres in 56 countries, and in 257,800 children aged 6-7 years in 91 centres in 38 countries. Ecological analyses were undertaken between symptom prevalence and the following: Gross National Product per capita (GNP), food intake, immunisation rates, tuberculosis notifications, climatic factors, tobacco consumption, pollen, antibiotic sales, paracetamol sales, and outdoor air pollution.Symptom prevalence of all three conditions was positively associated with GNP, trans fatty acids, paracetamol, and women smoking, and inversely associated with food of plant origin, pollen, immunisations, tuberculosis notifications, air pollution, and men smoking. The magnitude of these associations was small, but consistent in direction between conditions. There were mixed associations of climate and antibiotic sales with symptom prevalence.The potential causality of these associations warrant further investigation. Factors which prevent the development of these conditions, or where there is an absence of a positive correlation at a population level may be as important from the policy viewpoint as a focus on the positive risk factors. Interventions based on small associations may have the potential for a large public health benefit.

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U2 - 10.1186/1465-9921-11-8

DO - 10.1186/1465-9921-11-8

M3 - Review article

VL - 11

JO - Respiratory Research

JF - Respiratory Research

SN - 1465-9921

M1 - 8

ER -