Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate

Rajeev Jain, Rajeev Kumar Yadav, Jahangir Ahmad Rather

Research output: Contribution to journalArticle

15 Citations (Scopus)

Abstract

Assay and electrochemical behaviour of betahistine hydrochloride in Britton-Robinsons (BR) buffer of pH range 2.5-12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88% and 1.60% respectively, whereas the method accuracy was indicated by the recovery of 97.6-101.9%. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume366
Issue number1-3
DOIs
Publication statusPublished - 2010

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Keywords

  • Betahistine hydrochloride
  • Glassy carbon electrode
  • HPLC
  • Pharmaceutical formulation
  • Surfactant
  • Voltammetry

ASJC Scopus subject areas

  • Colloid and Surface Chemistry

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