Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate

Rajeev Jain, Rajeev Kumar Yadav, Jahangir Ahmad Rather

Research output: Contribution to journalArticle

14 Citations (Scopus)

Abstract

Assay and electrochemical behaviour of betahistine hydrochloride in Britton-Robinsons (BR) buffer of pH range 2.5-12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88% and 1.60% respectively, whereas the method accuracy was indicated by the recovery of 97.6-101.9%. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.

Original languageEnglish
Pages (from-to)63-67
Number of pages5
JournalColloids and Surfaces A: Physicochemical and Engineering Aspects
Volume366
Issue number1-3
DOIs
Publication statusPublished - 2010

Fingerprint

vertigo
Betahistine
hydrochlorides
Sodium dodecyl sulfate
sodium sulfates
Sodium Dodecyl Sulfate
Assays
drugs
Drug products
Pharmaceutical Preparations
Anionic surfactants
Cationic surfactants
surfactants
Glassy carbon
Surface active agents
Electrolytes
formulations
Recovery
Electrodes
Polysorbates

Keywords

  • Betahistine hydrochloride
  • Glassy carbon electrode
  • HPLC
  • Pharmaceutical formulation
  • Surfactant
  • Voltammetry

ASJC Scopus subject areas

  • Colloid and Surface Chemistry

Cite this

Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate. / Jain, Rajeev; Yadav, Rajeev Kumar; Rather, Jahangir Ahmad.

In: Colloids and Surfaces A: Physicochemical and Engineering Aspects, Vol. 366, No. 1-3, 2010, p. 63-67.

Research output: Contribution to journalArticle

@article{e398e1511be84b609022de3396ab539c,
title = "Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate",
abstract = "Assay and electrochemical behaviour of betahistine hydrochloride in Britton-Robinsons (BR) buffer of pH range 2.5-12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88{\%} and 1.60{\%} respectively, whereas the method accuracy was indicated by the recovery of 97.6-101.9{\%}. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.",
keywords = "Betahistine hydrochloride, Glassy carbon electrode, HPLC, Pharmaceutical formulation, Surfactant, Voltammetry",
author = "Rajeev Jain and Yadav, {Rajeev Kumar} and Rather, {Jahangir Ahmad}",
year = "2010",
doi = "10.1016/j.colsurfa.2010.05.027",
language = "English",
volume = "366",
pages = "63--67",
journal = "Colloids and Surfaces A: Physicochemical and Engineering Aspects",
issn = "0927-7757",
publisher = "Elsevier",
number = "1-3",

}

TY - JOUR

T1 - Voltammetric assay of anti-vertigo drug betahistine hydrochloride in sodium lauryl sulphate

AU - Jain, Rajeev

AU - Yadav, Rajeev Kumar

AU - Rather, Jahangir Ahmad

PY - 2010

Y1 - 2010

N2 - Assay and electrochemical behaviour of betahistine hydrochloride in Britton-Robinsons (BR) buffer of pH range 2.5-12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88% and 1.60% respectively, whereas the method accuracy was indicated by the recovery of 97.6-101.9%. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.

AB - Assay and electrochemical behaviour of betahistine hydrochloride in Britton-Robinsons (BR) buffer of pH range 2.5-12.0 at a glassy carbon electrode have been investigated. Addition of anionic surfactant (sodium lauryl sulphate) to the betahistine hydrochloride solution containing electrolyte enhanced the reduction current signal while neutral surfactant (Tween-20) and cationic surfactant cetyl trimethylammonium bromide (CTAB) showed an opposite effect. Voltammograms of betahistine hydrochloride exhibited a single wave. Based on reduction behaviour of betahistine hydrochloride, a direct square-wave voltammetric method has been developed for the assay of betahistine hydrochloride in pharmaceutical formulation. The proposed method has been validated as per ICH guideline. System and method precision in terms of RSD were 1.88% and 1.60% respectively, whereas the method accuracy was indicated by the recovery of 97.6-101.9%. Reduction peak current was linear over the target concentration with correlation coefficient 0.998. The proposed method was successfully applied to the determination of betahistine hydrochloride in pharmaceutical formulation. The results were compared with those obtained by the reference high performance liquid chromatographic method. No significant differences were found between results of proposed and reference methods.

KW - Betahistine hydrochloride

KW - Glassy carbon electrode

KW - HPLC

KW - Pharmaceutical formulation

KW - Surfactant

KW - Voltammetry

UR - http://www.scopus.com/inward/record.url?scp=77954384496&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954384496&partnerID=8YFLogxK

U2 - 10.1016/j.colsurfa.2010.05.027

DO - 10.1016/j.colsurfa.2010.05.027

M3 - Article

VL - 366

SP - 63

EP - 67

JO - Colloids and Surfaces A: Physicochemical and Engineering Aspects

JF - Colloids and Surfaces A: Physicochemical and Engineering Aspects

SN - 0927-7757

IS - 1-3

ER -