Varicella zoster virus pneumonitis and brainstem encephalitis without skin rash in an immunocompetent sadult

Ramachandiran Nandhagopal, Nelly Khmeleva, B. Jayakrishnan, Teresa White, Faisal Al Azri, Jojy George, Anna Heintzman, Khalfan A. Al Zeedy, Lucy Rorke-Adams, Arunodaya R. Gujjar, D. Scott Schmid, Abdullah Al-Asmi, Maria A. Nagel, Poovathoor Chacko Jacob, Don Gilden

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Varicella zoster virus (VZV) pneumonitis and brainstem encephalitis developed in an immunocompetent adult without rash. Chest computed tomography exhibited nodularity; lung biopsy revealed multinucleated giant cells, Cowdry A inclusions, VZV antigen, and DNA. Varicella zoster virus central nervous system disease was verified by cerebrospinal fluid (CSF) anti-VZV IgG antibody with reduced serum/CSF ratios.

Original languageEnglish
JournalOpen Forum Infectious Diseases
Issue number2
Publication statusPublished - 2014



  • Absence of rash
  • Brainstem encephalitis
  • Pneumonitis
  • VZV

ASJC Scopus subject areas

  • Oncology
  • Clinical Neurology

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