Utility of Head/Abdomen Circumference Ratio in the Evaluation of Severe Early-Onset Intrauterine Growth Restriction

Nihal al Riyami, Melissa G. Walker, Leslie K. Proctor, Yoav Yinon, Rory C. Windrim, John C P Kingdom

Research output: Contribution to journalArticle

12 Citations (Scopus)

Abstract

Objective: To determine whether the predominant phenotype of intrauterine growth restriction (IUGR) is symmetric or asymmetric in severe, early-onset disease due to placental insufficiency. Methods: We conducted a retrospective chart review of high-risk pregnant women with severe, early-onset IUGR who were delivering at < 33+0 weeks' gestation at Mount Sinai Hospital from 2001 to 2010. Ultrasound images were reviewed for fetal biometry, amniotic fluid volume, and uterine and umbilical Doppler flow studies within seven days of delivery, and the frequency of head circumference/abdominal circumference ratio ≥ 95th percentile for gestation was determined. Results: Sixty-two of 107 pregnancies (58%) with early-onset IUGR had an elevated HC/AC ratio (≥. 95th percentile), which was more than 10-fold greater than the expected proportion (P < 0.001). High rates of severe preeclampsia (53%), abnormal amniotic fluid (70%), and abnormal uterine artery Doppler studies (78%) indicated placental insufficiency. Conclusion: Fetuses with severe placental IUGR in the second trimester are more likely to have an asymmetric phenotype. This is in contrast to the current belief that asymmetric IUGR is confined to third trimester IUGR.

Original languageEnglish
Pages (from-to)715-719
Number of pages5
JournalJournal of Obstetrics and Gynaecology Canada
Volume33
Issue number7
DOIs
Publication statusPublished - 2011

Fingerprint

Abdomen
Head
Growth
Placental Insufficiency
Amniotic Fluid
Pregnancy
Biometry
Phenotype
Umbilicus
Uterine Artery
Third Pregnancy Trimester
Second Pregnancy Trimester
Pre-Eclampsia
Pregnant Women
Fetus

Keywords

  • Asymmetrical
  • Fetal biometry
  • Intrauterine growth restriction
  • Phenotype
  • Symmetrical
  • Ultrasonography

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Utility of Head/Abdomen Circumference Ratio in the Evaluation of Severe Early-Onset Intrauterine Growth Restriction. / Riyami, Nihal al; Walker, Melissa G.; Proctor, Leslie K.; Yinon, Yoav; Windrim, Rory C.; Kingdom, John C P.

In: Journal of Obstetrics and Gynaecology Canada, Vol. 33, No. 7, 2011, p. 715-719.

Research output: Contribution to journalArticle

Riyami, Nihal al ; Walker, Melissa G. ; Proctor, Leslie K. ; Yinon, Yoav ; Windrim, Rory C. ; Kingdom, John C P. / Utility of Head/Abdomen Circumference Ratio in the Evaluation of Severe Early-Onset Intrauterine Growth Restriction. In: Journal of Obstetrics and Gynaecology Canada. 2011 ; Vol. 33, No. 7. pp. 715-719.
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