Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus

A. S. Al-Ansari, W. E.R. Ollier, J. Villarreal, J. Ordi, L. S. Teh, Ali H. Hajeer

Research output: Contribution to journalArticle

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Abstract

Systemic lupus erythematosus (SLE) is a complex autoimmune disease that exhibits extensive clinical heterogeneity. Several studies have suggested a role for tumor necrosis factor A (TNFA) in SLE and recently, the locus encompassing the TNF receptor II (TNFRII), which is a mediator of TNF effect, was amongst the candidate loci suggested by genetic linkage studies of multi-case SLE families. Komata et al. reported an association between a polymorphism at position 196 (R allele) of TNFR II and SLE in Japanese patients. We have typed SLE patients from two different ethnic populations, Spanish and UK Caucasoids, for this polymorphism using a polymerase chain reaction and restriction fragment length polymorphism (PCR-RFLP)-based technique. No significant differences in allele or genotype frequencies were found between cases and matched controls in either population. The TNFRII 196R allele does not appear to be associated with SLE susceptibility in either Spanish or UK populations.

Original languageEnglish
Pages (from-to)97-99
Number of pages3
JournalTissue Antigens
Volume55
Issue number1
DOIs
Publication statusPublished - 2000

Fingerprint

Tumor Necrosis Factor Receptors
Polymorphism
Systemic Lupus Erythematosus
Exons
Polymerase chain reaction
Alleles
Tumor Necrosis Factor-alpha
Population
Genetic Linkage
Restriction Fragment Length Polymorphisms
Autoimmune Diseases
Genotype
Polymerase Chain Reaction

Keywords

  • Genetics
  • Polymorphism
  • SLE
  • TNFR II

ASJC Scopus subject areas

  • Immunology and Allergy
  • Immunology
  • Biochemistry
  • Genetics

Cite this

Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus. / Al-Ansari, A. S.; Ollier, W. E.R.; Villarreal, J.; Ordi, J.; Teh, L. S.; Hajeer, Ali H.

In: Tissue Antigens, Vol. 55, No. 1, 2000, p. 97-99.

Research output: Contribution to journalArticle

Al-Ansari, A. S. ; Ollier, W. E.R. ; Villarreal, J. ; Ordi, J. ; Teh, L. S. ; Hajeer, Ali H. / Tumor necrosis factor receptor II (TNFRII) exon 6 polymorphism in systemic lupus erythematosus. In: Tissue Antigens. 2000 ; Vol. 55, No. 1. pp. 97-99.
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