Transfusion transmitted diseases in haemophilics from western India

K. Ghosh, S. H. Joshi, S. Shetty, A. Pawar, S. Chipkar, V. Pujari, M. Madkaikar, A. V. Pathare, F. Jijina, D. Mohanty

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Background and objectives: Transfusion related human immunodeficiency virus (HIV), hepatitis B virus (HBV) and hepatitis C virus (HCV) infections have been a major cause for mobidity and mortality in the haemophilic population in the west. The prevalence of these markers of transfusion transmitted viral diseases in severe and moderate haemophilia patients was studied. Methods: The seropositivity for these viral markers was evaluated in 400 haemophilics (323 severe and 77 moderate) in a 5-year survey starting from 1995. First 188 of these patients were also tested for HCV. Serological tests for HIV, HBsAg and HCV were done by third generation ELISA; positive samples were also confirmed by Western blot. Results: Fifteen of the 400 patients were found to be HIV positive (3.8%), 24/400 were HBsAg positive (6%) and 45/188 (23.9%) were positive for HCV (28 for both non-structural and core antigen, 13 for core only and 4 for non-structural antigen only). The lowest age of HIV positivity was 12 yr and that of HCV positivity was 8 yr. Interpretation and conclusion: The above study shows a reduction in blood product related HIV transmission in severe and moderately affected haemophilics but more stringent policy for blood product usage, universal hepatitis C screening, hepatitis B vaccination and continuous awareness programmes for medical staff, general public and patients is needed to reduce the incidence of these diseases in haemophilics.

Original languageEnglish
Pages (from-to)61-64
Number of pages4
JournalIndian Journal of Medical Research
Volume112
Issue numberAUG.
Publication statusPublished - 2000

Fingerprint

Viruses
Hepacivirus
India
HIV
Virus Diseases
Hepatitis B Surface Antigens
Antigens
Immunization Programs
Medical Staff
Hemophilia A
Serologic Tests
Hepatitis C
Hepatitis B
Hepatitis B virus
Biomarkers
Western Blotting
Enzyme-Linked Immunosorbent Assay
Blood
Mortality
Incidence

Keywords

  • Haemophilia
  • Hepatitis
  • Hepatitis B
  • HIV infection
  • Lymphocyte subpopulation

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Ghosh, K., Joshi, S. H., Shetty, S., Pawar, A., Chipkar, S., Pujari, V., ... Mohanty, D. (2000). Transfusion transmitted diseases in haemophilics from western India. Indian Journal of Medical Research, 112(AUG.), 61-64.

Transfusion transmitted diseases in haemophilics from western India. / Ghosh, K.; Joshi, S. H.; Shetty, S.; Pawar, A.; Chipkar, S.; Pujari, V.; Madkaikar, M.; Pathare, A. V.; Jijina, F.; Mohanty, D.

In: Indian Journal of Medical Research, Vol. 112, No. AUG., 2000, p. 61-64.

Research output: Contribution to journalArticle

Ghosh, K, Joshi, SH, Shetty, S, Pawar, A, Chipkar, S, Pujari, V, Madkaikar, M, Pathare, AV, Jijina, F & Mohanty, D 2000, 'Transfusion transmitted diseases in haemophilics from western India', Indian Journal of Medical Research, vol. 112, no. AUG., pp. 61-64.
Ghosh K, Joshi SH, Shetty S, Pawar A, Chipkar S, Pujari V et al. Transfusion transmitted diseases in haemophilics from western India. Indian Journal of Medical Research. 2000;112(AUG.):61-64.
Ghosh, K. ; Joshi, S. H. ; Shetty, S. ; Pawar, A. ; Chipkar, S. ; Pujari, V. ; Madkaikar, M. ; Pathare, A. V. ; Jijina, F. ; Mohanty, D. / Transfusion transmitted diseases in haemophilics from western India. In: Indian Journal of Medical Research. 2000 ; Vol. 112, No. AUG. pp. 61-64.
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