TY - JOUR
T1 - Tin disulfide nanorod-graphene-β-cyclodextrin nanocomposites for sensing dopamine in rat brains and human blood serum
AU - Balu, Sridharan
AU - Palanisamy, Selvakumar
AU - Velusamy, Vijaylakshmi
AU - Yang, Thomas C.K.
AU - El-Shafey, El Said I.
N1 - Funding Information:
This project was supported by the Ministry of Science and Technology (project No: 106-2119- M -027-001 ) of Taiwan. This work was jointly sponsored by the Engineering and Materials Research Centre (EMRC) , School of Engineering, Manchester Metropolitan University , Manchester, UK. Authors also would like to acknowledge the Precision analysis and Materials Research Center, National Taipei University of Technology for providing the all-necessary Instrument facilities.
PY - 2020/3
Y1 - 2020/3
N2 - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.
AB - In the present work describes a facile synthesis of tin disulfide (SnS2) nanorods decorated graphene-β-cyclodextrin (SnS2/GR-β-CD) nanocomposite for robust and novel dopamine (DA) electrochemical biosensor applications. The DA biosensor was fabricated using the glassy carbon electrode (GCE) modified with SnS2/GR-β-CD nanocomposite. The sonochemical and hydrothermal methods have been used for the synthesis of SnS2/GR-β-CD. Different physicochemical methods were used to confirm the formation of the GR-β-CD, SnS2, and SnS2/GR-β-CD nanocomposite. The cyclicvoltammetric cathodic current response of DA was 5 folds higher than those observed at bare, β-CD, SnS2-β-CD, and GR-β-CD modified GCEs. Under optimised conditions, the biosensor's DPV response current is linear to DA from the concentration of 0.01–150.76 μM. The detection limit of the biosensor was 4 nM. The SnS2/GR-β-CD biosensor shows an excellent selectivity towards DA in the presence of common interfering species, including ascorbic acid and uric acid. Also, the as-prepared nanocomposite-modified electrode exhibited satisfactory long-term stability, sensitivity (2.49 μAμM−1 cm−2) along with reusability for detection of DA. The fabricated SnS2/GR-β-CD biosensor was successfully used for the detection of DA in the rat brain and human blood serum samples.
KW - Biosensor
KW - Dopamine
KW - Graphene nanocomposite
KW - Guest-host chemistry
KW - SnS nanorods
KW - Sonochemical method
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U2 - 10.1016/j.msec.2019.110367
DO - 10.1016/j.msec.2019.110367
M3 - Article
C2 - 31923993
AN - SCOPUS:85074996006
SN - 0928-4931
VL - 108
JO - Materials Science and Engineering C
JF - Materials Science and Engineering C
M1 - 110367
ER -