The prothrombotic state in hypertension and the effects of antihypertensive treatment

Sunil Nadar, Gregory Y H Lip

Research output: Contribution to journalReview article

64 Citations (Scopus)

Abstract

Hypertension is associated with the flow of blood under high pressures, yet the complications of hypertension, such as myocardial infarction or stroke are paradoxically thrombotic rather than haemorrhagic. This could be explained by increasing evidence which suggests that hypertension fulfils the pre-requisites of the Virchow's triad for thrombogenesis, leading to a prothrombotic or hypercoagulable state. Hypertension leads to changes in the platelets, endothelium and the coagulation and fibrinolytic pathways which help to promote the induction and the maintenance of this prothrombotic state. These changes can to a certain extent be reversed by the treatment of hypertension, although different antihypertensive agents may have variable effects in reversing these changes. Some of the effects may be simply related to normalisation of blood pressure, but certain groups of drugs such as those acting on the renin-angiotensin-aldosterone system appear to have an effect over and above this. Anti-platelet agents have also been shown to confer a degree of benefit to 'high risk' hypertensive patients. The study of the prothrombotic state in hypertension is therefore of paramount importance, as understanding the pathogenic processes underlying it can help prevent many of the complications associated with this condition.

Original languageEnglish
Pages (from-to)1715-1732
Number of pages18
JournalCurrent Pharmaceutical Design
Volume9
Issue number21
DOIs
Publication statusPublished - 2003

Fingerprint

Antihypertensive Agents
Hypertension
Therapeutics
Blood Platelets
Renin-Angiotensin System
Endothelium
Stroke
Myocardial Infarction
Maintenance
Blood Pressure
Pharmaceutical Preparations

Keywords

  • Antihypertensive agents
  • Antiplatelet agents
  • Endothelial dysfunction
  • Hypertension
  • Platelet activation
  • Thrombosis

ASJC Scopus subject areas

  • Molecular Medicine
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

The prothrombotic state in hypertension and the effects of antihypertensive treatment. / Nadar, Sunil; Lip, Gregory Y H.

In: Current Pharmaceutical Design, Vol. 9, No. 21, 2003, p. 1715-1732.

Research output: Contribution to journalReview article

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