The effect of thyroxine or carbimazole treatment on gentamicin nephrotoxicity in rats

B. H. Ali, A. A. Bashir, M. O M Tanira

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Abstract

1. This study examines the effect of treating rats with gentamicin (80 mg kg -1 day -1 intramuscularly (i.m.), for 6 days) alone or with either L-thyroxine or the anti-thyroid drug carbimazole. 2. Gentamicin produced significant increases in serum creatinine and urea concentrations, and significantly reduced the activity of Na +,K +ATPase in renal cortex. The concentration of serum triiodothyronine (T 3) was unaffected by graded doses (20, 40 and 80 mg kg -1) of the antibiotic. Histopathologically, gentamicin produced necrosis of proximal tubules in the renal cortical tissues of treated rats. 3. Treatment of rats with either L-thyroxine or carbimazole alone did not significantly affect any of the biochemical variables investigated. Carbimazole alone produced only mild tubular necrosis. 4. Treatment of rats with either L-thyroxine (100 μg kg -1 day -1, subcutaneously) for 10 days, and gentamicin (80 mg kg -1, i.m. daily during the last 6 days of treatment significantly reduced the gentamicin-induced increases in serum creatinine and urea concentrations, and increased the activity of cortical N +,K +ATPase to control levels. Histopathologically, the severity of gentamicin-induced tubular necrosis was reduced by L-thyroxine treatment. 5. Carbimazole (12 mg ml -1 in drinking water for 21 days) and gentamicin (80 mg kg -1 i.m.) daily during the last 6 days of treatment, stimulated the increase in serum urea concentration produced by gentamicin, but did not significantly affect the gentamicin-induced changes in serum creatinine or cortical N +,K +ATPase.

Original languageEnglish
Pages (from-to)13-17
Number of pages5
JournalHuman and Experimental Toxicology
Volume14
Issue number1
Publication statusPublished - 1995

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Keywords

  • Carbimazole
  • Gentamicin
  • Nephroprotection
  • Nephrotoxicity
  • Thyroxine

ASJC Scopus subject areas

  • Health, Toxicology and Mutagenesis
  • Toxicology

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