The effect of swimming exercise on adenine-induced kidney disease in rats, and the inffuence of curcumin or lisinopril thereon

Badreldin H. Ali, Turan Karaca, Yousuf Al Suleimani, Mohammed Al Za'abi, Jamila Al Kalbani, Mohammed Ashique, Abderrahim Nemmar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.

Original languageEnglish
Article numbere0176316
JournalPLoS One
Volume12
Issue number4
DOIs
Publication statusPublished - Apr 1 2017

Fingerprint

Lisinopril
Curcumin
curcumin
Kidney Diseases
Adenine
adenine
kidney diseases
Rats
exercise
Exercise
Chronic Renal Insufficiency
rats
Creatinine
creatinine
Indican
Food
Blood pressure
Swimming
Biological Products
Angiotensin-Converting Enzyme Inhibitors

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

The effect of swimming exercise on adenine-induced kidney disease in rats, and the inffuence of curcumin or lisinopril thereon. / Ali, Badreldin H.; Karaca, Turan; Suleimani, Yousuf Al; Za'abi, Mohammed Al; Kalbani, Jamila Al; Ashique, Mohammed; Nemmar, Abderrahim.

In: PLoS One, Vol. 12, No. 4, e0176316, 01.04.2017.

Research output: Contribution to journalArticle

@article{1c0a1231234649788e3be04b32de774d,
title = "The effect of swimming exercise on adenine-induced kidney disease in rats, and the inffuence of curcumin or lisinopril thereon",
abstract = "Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25{\%} w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.",
author = "Ali, {Badreldin H.} and Turan Karaca and Suleimani, {Yousuf Al} and Za'abi, {Mohammed Al} and Kalbani, {Jamila Al} and Mohammed Ashique and Abderrahim Nemmar",
year = "2017",
month = "4",
day = "1",
doi = "10.1371/journal.pone.0176316",
language = "English",
volume = "12",
journal = "PLoS One",
issn = "1932-6203",
publisher = "Public Library of Science",
number = "4",

}

TY - JOUR

T1 - The effect of swimming exercise on adenine-induced kidney disease in rats, and the inffuence of curcumin or lisinopril thereon

AU - Ali, Badreldin H.

AU - Karaca, Turan

AU - Suleimani, Yousuf Al

AU - Za'abi, Mohammed Al

AU - Kalbani, Jamila Al

AU - Ashique, Mohammed

AU - Nemmar, Abderrahim

PY - 2017/4/1

Y1 - 2017/4/1

N2 - Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.

AB - Patients with chronic kidney disease (CKD) have been reported to benefit from different types of exercises. It has also been shown that the ACE inhibitor lisinopril, and the natural product curcumin are also beneficial in different models of CKD in rats. We assessed the influence of moderate swimming exercise (SE) on rats with adenine-induced CKD, and tested the possible effects of lisinopril and/or curcumin thereon using several physiological, biochemical, histopathological and immunohistochemical parameters. Rats (either sedentary or subjected to SE) were randomly divided into several groups, and given for five weeks either normal food or food mixed with adenine (0.25% w/w) to induce CKD. Some of these groups were also concomitantly treated orally with curcumin (75 mg/kg), or lisinopril (10 mg/kg) and were subjected to moderate SE (45 min/day three days each week). Rats fed adenine showed the typical biochemical, histopathological signs of CKD such as elevations in blood pressure, urinary albumin / creatinine ratio, and plasma urea, creatinine, indoxyl sulfate and phosphorus. SE, curcumin or lisinopril, given singly, significantly ameliorated all the adenine-induced actions. Administering curcumin or lisinopril with SE improved the histopathology of the kidneys, a salutary effect not seen with SE alone. Combining SE to the nephroprotective agents' curcumin or lisinopril might offer additional nephroprotection.

UR - http://www.scopus.com/inward/record.url?scp=85018364317&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85018364317&partnerID=8YFLogxK

U2 - 10.1371/journal.pone.0176316

DO - 10.1371/journal.pone.0176316

M3 - Article

C2 - 28445490

AN - SCOPUS:85018364317

VL - 12

JO - PLoS One

JF - PLoS One

SN - 1932-6203

IS - 4

M1 - e0176316

ER -