The effect of bergamot on dyslipidemia

Rosaria Vincenza Giglio, Angelo Maria Patti, Dragana Nikolic, Giovanni Li Volti, Khalid Al-Rasadi, Niki Katsiki, Dimitri P. Mikhailidis, Giuseppe Montalto, Ekaterina Ivanova, Alexander N. Orekhov, Manfredi Rizzo

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

Original languageEnglish
JournalPhytomedicine
DOIs
Publication statusAccepted/In press - Sep 29 2015

Fingerprint

Dyslipidemias
Lipids
Citrus
Hydroxymethylglutaryl-CoA Reductase Inhibitors
Dietary Supplements
Flavonoids
Pharmaceutical Preparations
Health
Therapeutics

Keywords

  • Bergamot
  • Cardiovascular risk
  • Dyslipidemia
  • LDL cholesterol

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

Cite this

Giglio, R. V., Patti, A. M., Nikolic, D., Li Volti, G., Al-Rasadi, K., Katsiki, N., ... Rizzo, M. (Accepted/In press). The effect of bergamot on dyslipidemia. Phytomedicine. https://doi.org/10.1016/j.phymed.2015.12.005

The effect of bergamot on dyslipidemia. / Giglio, Rosaria Vincenza; Patti, Angelo Maria; Nikolic, Dragana; Li Volti, Giovanni; Al-Rasadi, Khalid; Katsiki, Niki; Mikhailidis, Dimitri P.; Montalto, Giuseppe; Ivanova, Ekaterina; Orekhov, Alexander N.; Rizzo, Manfredi.

In: Phytomedicine, 29.09.2015.

Research output: Contribution to journalArticle

Giglio, RV, Patti, AM, Nikolic, D, Li Volti, G, Al-Rasadi, K, Katsiki, N, Mikhailidis, DP, Montalto, G, Ivanova, E, Orekhov, AN & Rizzo, M 2015, 'The effect of bergamot on dyslipidemia', Phytomedicine. https://doi.org/10.1016/j.phymed.2015.12.005
Giglio RV, Patti AM, Nikolic D, Li Volti G, Al-Rasadi K, Katsiki N et al. The effect of bergamot on dyslipidemia. Phytomedicine. 2015 Sep 29. https://doi.org/10.1016/j.phymed.2015.12.005
Giglio, Rosaria Vincenza ; Patti, Angelo Maria ; Nikolic, Dragana ; Li Volti, Giovanni ; Al-Rasadi, Khalid ; Katsiki, Niki ; Mikhailidis, Dimitri P. ; Montalto, Giuseppe ; Ivanova, Ekaterina ; Orekhov, Alexander N. ; Rizzo, Manfredi. / The effect of bergamot on dyslipidemia. In: Phytomedicine. 2015.
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