The effect of bergamot on dyslipidemia

Rosaria Vincenza Giglio, Angelo Maria Patti, Dragana Nikolic, Giovanni Li Volti, Khalid Al-Rasadi, Niki Katsiki, Dimitri P. Mikhailidis, Giuseppe Montalto, Ekaterina Ivanova, Alexander N. Orekhov, Manfredi Rizzo

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

Original languageEnglish
JournalPhytomedicine
DOIs
Publication statusAccepted/In press - Sep 29 2015

Keywords

  • Bergamot
  • Cardiovascular risk
  • Dyslipidemia
  • LDL cholesterol

ASJC Scopus subject areas

  • Drug Discovery
  • Pharmacology
  • Pharmaceutical Science
  • Complementary and alternative medicine
  • Molecular Medicine

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  • Cite this

    Giglio, R. V., Patti, A. M., Nikolic, D., Li Volti, G., Al-Rasadi, K., Katsiki, N., Mikhailidis, D. P., Montalto, G., Ivanova, E., Orekhov, A. N., & Rizzo, M. (Accepted/In press). The effect of bergamot on dyslipidemia. Phytomedicine. https://doi.org/10.1016/j.phymed.2015.12.005