The effect of bergamot on dyslipidemia

Rosaria Vincenza Giglio; Angelo Maria Patti; Dragana Nikolic; Giovanni Li Volti; Khalid Al-Rasadi; Niki Katsiki; Dimitri P. Mikhailidis; Giuseppe Montalto; Ekaterina Ivanova; Alexander N. Orekhov; Manfredi Rizzo

doi:10.1016/j.phymed.2015.12.005

The effect of bergamot on dyslipidemia

Rosaria Vincenza Giglio, Angelo Maria Patti, Dragana Nikolic, Giovanni Li Volti, Khalid Al-Rasadi, Niki Katsiki, Dimitri P. Mikhailidis, Giuseppe Montalto, Ekaterina Ivanova, Alexander N. Orekhov, Manfredi Rizzo^*

^*Corresponding author for this work

Biochemistry

Research output: Contribution to journal › Article › peer-review

29 Citations (Scopus)

Abstract

Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

Original language	English
Journal	Phytomedicine
DOIs	https://doi.org/10.1016/j.phymed.2015.12.005
Publication status	Accepted/In press - Sept 29 2015

Keywords

Bergamot
Cardiovascular risk
Dyslipidemia
LDL cholesterol

ASJC Scopus subject areas

Drug Discovery
Pharmacology
Pharmaceutical Science
Complementary and alternative medicine
Molecular Medicine

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10.1016/j.phymed.2015.12.005

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title = "The effect of bergamot on dyslipidemia",

abstract = "Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.",

keywords = "Bergamot, Cardiovascular risk, Dyslipidemia, LDL cholesterol",

author = "Giglio, {Rosaria Vincenza} and Patti, {Angelo Maria} and Dragana Nikolic and {Li Volti}, Giovanni and Khalid Al-Rasadi and Niki Katsiki and Mikhailidis, {Dimitri P.} and Giuseppe Montalto and Ekaterina Ivanova and Orekhov, {Alexander N.} and Manfredi Rizzo",

year = "2015",

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day = "29",

doi = "10.1016/j.phymed.2015.12.005",

language = "English",

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AU - Giglio, Rosaria Vincenza

AU - Patti, Angelo Maria

AU - Nikolic, Dragana

AU - Li Volti, Giovanni

AU - Al-Rasadi, Khalid

AU - Katsiki, Niki

AU - Mikhailidis, Dimitri P.

AU - Montalto, Giuseppe

AU - Ivanova, Ekaterina

AU - Orekhov, Alexander N.

AU - Rizzo, Manfredi

PY - 2015/9/29

Y1 - 2015/9/29

N2 - Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

AB - Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.

KW - Bergamot

KW - Cardiovascular risk

KW - Dyslipidemia

KW - LDL cholesterol

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The effect of bergamot on dyslipidemia

Abstract

Keywords

ASJC Scopus subject areas

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