Abstract
Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
| Original language | English |
|---|---|
| Journal | Phytomedicine |
| DOIs | |
| Publication status | Accepted/In press - Sep 29 2015 |
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Keywords
- Bergamot
- Cardiovascular risk
- Dyslipidemia
- LDL cholesterol
ASJC Scopus subject areas
- Drug Discovery
- Pharmacology
- Pharmaceutical Science
- Complementary and alternative medicine
- Molecular Medicine
Cite this
The effect of bergamot on dyslipidemia. / Giglio, Rosaria Vincenza; Patti, Angelo Maria; Nikolic, Dragana; Li Volti, Giovanni; Al-Rasadi, Khalid; Katsiki, Niki; Mikhailidis, Dimitri P.; Montalto, Giuseppe; Ivanova, Ekaterina; Orekhov, Alexander N.; Rizzo, Manfredi.
In: Phytomedicine, 29.09.2015.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - The effect of bergamot on dyslipidemia
AU - Giglio, Rosaria Vincenza
AU - Patti, Angelo Maria
AU - Nikolic, Dragana
AU - Li Volti, Giovanni
AU - Al-Rasadi, Khalid
AU - Katsiki, Niki
AU - Mikhailidis, Dimitri P.
AU - Montalto, Giuseppe
AU - Ivanova, Ekaterina
AU - Orekhov, Alexander N.
AU - Rizzo, Manfredi
PY - 2015/9/29
Y1 - 2015/9/29
N2 - Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
AB - Background: Statins are the most common used lipid lowering drugs but they may cause adverse effects and despite their well-established therapeutic benefits residual cardiovascular (CV) risk remains. The use of other lipid lowering drugs and nutraceuticals alone or as add-on lipid-modifying therapy can be an option in such cases. Several studies have reported health-related properties of the Citrus fruits, among which bergamot (Citrus bergamia Risso) differs from others by particularly high content of certain compounds. Purpose: This narrative review summarizes the current evidence on the effects of bergamot on lipid parameters based on studies involving animals and humans. Main evidence: This natural supplement may lead to effective lipid-lowering treatment. Its lipid-lowering activity is attributed to different flavonoids. However, the exact mechanisms involved remain unclear. Conclusion: It is expected that ongoing and future studies will confirm the benefit of bergamot in dyslipidemic and other cardiometabolic disorders, potentially leading to reduced overall CV risk.
KW - Bergamot
KW - Cardiovascular risk
KW - Dyslipidemia
KW - LDL cholesterol
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UR - http://www.scopus.com/inward/citedby.url?scp=84956701357&partnerID=8YFLogxK
U2 - 10.1016/j.phymed.2015.12.005
DO - 10.1016/j.phymed.2015.12.005
M3 - Article
C2 - 26851838
AN - SCOPUS:84956701357
JO - Phytomedicine
JF - Phytomedicine
SN - 0944-7113
ER -