The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol

Hilal Al-Sabti; Ali T. Al-Hinai; Ibrahim Al-Zakwani; Khamis Al-Hashmi; Wael Al Mahmeed; Mohamed Arafah; Abdullah Shehab; Omer Al Tamimi; Mahmoud Al Awadhi; Shorook Al Herz; Faisal Al Anazi; Khalid Al Nemer; Othman Metwally; Akram Alkhadra; Mohammed Fakhry; Hossam Elghetany; Abdel Razak Medani; Afzal Hussein Yusufali; Obaid Al Jassim; Omar Al Hallaq; Fahad Omar Ahmed S. Baslaib; Haitham Amin; Khalid Al-Waili; Khalid Al-Rasadi

doi:10.5001/omj.2022.79

The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol

Hilal Al-Sabti, Ali T. Al-Hinai, Ibrahim Al-Zakwani, Khamis Al-Hashmi, Wael Al Mahmeed, Mohamed Arafah, Abdullah Shehab, Omer Al Tamimi, Mahmoud Al Awadhi, Shorook Al Herz, Faisal Al Anazi, Khalid Al Nemer, Othman Metwally, Akram Alkhadra, Mohammed Fakhry, Hossam Elghetany, Abdel Razak Medani, Afzal Hussein Yusufali, Obaid Al Jassim, Omar Al HallaqFahad Omar Ahmed S. Baslaib, Haitham Amin, Khalid Al-Waili, Khalid Al-Rasadi^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

OBJECTIVES: We sought to estimate the percentage achievements of non-high-density lipoprotein cholesterol (non-HDL-C) target in patients with very high atheroscleroticcardiovascular diseases (ASCVD) risk stratified by triglyceride (TG) levels despite statin-controlled low-density lipoprotein cholesterol (LDL-C) in the Centralized Pan-Middle East Survey on the under treatment of hypercholesterolemia.

METHODS: The non-HDL-C target achievement in patients with diabetes mellites (DM) and patients with established ASCVD was defined according to European Society of Cardiology and European Atherosclerosis Society 2019 guidelines for managing dyslipidemia. Patients were stratified to controlled LDL-C defined as < 70 mg/dL (< 1.8 mmol/L) with normal TG < 150 mg/dL (< 1.7 mmol/L) and high TG between 150-400 mg/dL (1.7-4.5 mmol/L).

RESULTS: The mean age of our cohort was 58.0±11.0 years, 6.8% (n = 717) were male, 9.7% (104) were smokers, and 48.4% (n = 518) had body mass index of ≥ 30 kg/m 2. Those with high TG levels male (76.5% vs. 63.8%; p < 0.001), smokers (16.1% vs. 7.7%; p < 0.001), have metabolic syndrome (77.6% vs. 17.1%; p < 0.001), and low HDL-C levels (79.2% vs. 49.4%; p < 0.001). The majority (93.9%, n = 1008) were on statins (atorvastatin and rosuvastatin) with only 2.2% (n = 24) on the combined statins plus fenofibrate/gemfibrozil. Only 27.4% (n = 294) of patients had non-HDL-C goal attainment. Goal attainment rates in patients with diabetes (3.1% vs. 34,4%; p < 0.001), coronary artery disease (CAD) (2.4% vs. 37.9%; p < 0.001), diabetes plus CAD (0% vs. 40.0%; p < 0.001), and CVD (0% vs. 30.0%; p = 0.048) were significantly lower in those with higher TG levels.

CONCLUSIONS: A large proportion of statin-controlled LDL-C diabetic patients and patients with established ASCVD with high TGs did not achieve the non-HDL-C target. Our study did not demonstrate an association between ASCVD and high TG levels; and therefore, a follow-up study is highly required to assess long-term ASCVD outcomes in this cohort.

Original language	English
Article number	e367
Pages (from-to)	e367
Journal	Oman Medical Journal
Volume	37
Issue number	2
DOIs	https://doi.org/10.5001/omj.2022.79
Publication status	Published - Mar 22 2022

Keywords

Arabs
Cardiovascular Diseases
Cholesterol
Diabetes Mellitus
LDL
Risk Factors
Triglycerides

ASJC Scopus subject areas

General Medicine

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Al-Sabti, H., Al-Hinai, A. T., Al-Zakwani, I., Al-Hashmi, K., Al Mahmeed, W., Arafah, M., Shehab, A., Al Tamimi, O., Al Awadhi, M., Al Herz, S., Al Anazi, F., Al Nemer, K., Metwally, O., Alkhadra, A., Fakhry, M., Elghetany, H., Medani, A. R., Yusufali, A. H., Al Jassim, O., ... Al-Rasadi, K. (2022). The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol. Oman Medical Journal, 37(2), e367. Article e367. https://doi.org/10.5001/omj.2022.79

The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol. / Al-Sabti, Hilal; Al-Hinai, Ali T.; Al-Zakwani, Ibrahim et al.
In: Oman Medical Journal, Vol. 37, No. 2, e367, 22.03.2022, p. e367.

Research output: Contribution to journal › Article › peer-review

Al-Sabti, H, Al-Hinai, AT, Al-Zakwani, I , Al-Hashmi, K, Al Mahmeed, W, Arafah, M, Shehab, A, Al Tamimi, O, Al Awadhi, M, Al Herz, S, Al Anazi, F, Al Nemer, K, Metwally, O, Alkhadra, A, Fakhry, M, Elghetany, H, Medani, AR, Yusufali, AH, Al Jassim, O, Al Hallaq, O, Baslaib, FOAS, Amin, H, Al-Waili, K & Al-Rasadi, K 2022, 'The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol', Oman Medical Journal, vol. 37, no. 2, e367, pp. e367. https://doi.org/10.5001/omj.2022.79

Al-Sabti H, Al-Hinai AT, Al-Zakwani I , Al-Hashmi K, Al Mahmeed W, Arafah M et al. The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol. Oman Medical Journal. 2022 Mar 22;37(2):e367. e367. doi: 10.5001/omj.2022.79

@article{341b5142c10342f38b3120def2096fa6,

title = "The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol",

abstract = "OBJECTIVES: We sought to estimate the percentage achievements of non-high-density lipoprotein cholesterol (non-HDL-C) target in patients with very high atheroscleroticcardiovascular diseases (ASCVD) risk stratified by triglyceride (TG) levels despite statin-controlled low-density lipoprotein cholesterol (LDL-C) in the Centralized Pan-Middle East Survey on the under treatment of hypercholesterolemia.METHODS: The non-HDL-C target achievement in patients with diabetes mellites (DM) and patients with established ASCVD was defined according to European Society of Cardiology and European Atherosclerosis Society 2019 guidelines for managing dyslipidemia. Patients were stratified to controlled LDL-C defined as < 70 mg/dL (< 1.8 mmol/L) with normal TG < 150 mg/dL (< 1.7 mmol/L) and high TG between 150-400 mg/dL (1.7-4.5 mmol/L).RESULTS: The mean age of our cohort was 58.0±11.0 years, 6.8% (n = 717) were male, 9.7% (104) were smokers, and 48.4% (n = 518) had body mass index of ≥ 30 kg/m 2. Those with high TG levels male (76.5% vs. 63.8%; p < 0.001), smokers (16.1% vs. 7.7%; p < 0.001), have metabolic syndrome (77.6% vs. 17.1%; p < 0.001), and low HDL-C levels (79.2% vs. 49.4%; p < 0.001). The majority (93.9%, n = 1008) were on statins (atorvastatin and rosuvastatin) with only 2.2% (n = 24) on the combined statins plus fenofibrate/gemfibrozil. Only 27.4% (n = 294) of patients had non-HDL-C goal attainment. Goal attainment rates in patients with diabetes (3.1% vs. 34,4%; p < 0.001), coronary artery disease (CAD) (2.4% vs. 37.9%; p < 0.001), diabetes plus CAD (0% vs. 40.0%; p < 0.001), and CVD (0% vs. 30.0%; p = 0.048) were significantly lower in those with higher TG levels. CONCLUSIONS: A large proportion of statin-controlled LDL-C diabetic patients and patients with established ASCVD with high TGs did not achieve the non-HDL-C target. Our study did not demonstrate an association between ASCVD and high TG levels; and therefore, a follow-up study is highly required to assess long-term ASCVD outcomes in this cohort.",

keywords = "Arabs, Cardiovascular Diseases, Cholesterol, Diabetes Mellitus, LDL, Risk Factors, Triglycerides",

author = "Hilal Al-Sabti and Al-Hinai, {Ali T.} and Ibrahim Al-Zakwani and Khamis Al-Hashmi and {Al Mahmeed}, Wael and Mohamed Arafah and Abdullah Shehab and {Al Tamimi}, Omer and {Al Awadhi}, Mahmoud and {Al Herz}, Shorook and {Al Anazi}, Faisal and {Al Nemer}, Khalid and Othman Metwally and Akram Alkhadra and Mohammed Fakhry and Hossam Elghetany and Medani, {Abdel Razak} and Yusufali, {Afzal Hussein} and {Al Jassim}, Obaid and {Al Hallaq}, Omar and Baslaib, {Fahad Omar Ahmed S.} and Haitham Amin and Khalid Al-Waili and Khalid Al-Rasadi",

year = "2022",

month = mar,

day = "22",

doi = "10.5001/omj.2022.79",

language = "English",

volume = "37",

pages = "e367",

journal = "Oman Medical Journal",

issn = "1999-768X",

publisher = "Oman Medical Specialty Board",

number = "2",

}

TY - JOUR

T1 - The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol

AU - Al-Sabti, Hilal

AU - Al-Hinai, Ali T.

AU - Al-Zakwani, Ibrahim

AU - Al-Hashmi, Khamis

AU - Al Mahmeed, Wael

AU - Arafah, Mohamed

AU - Shehab, Abdullah

AU - Al Tamimi, Omer

AU - Al Awadhi, Mahmoud

AU - Al Herz, Shorook

AU - Al Anazi, Faisal

AU - Al Nemer, Khalid

AU - Metwally, Othman

AU - Alkhadra, Akram

AU - Fakhry, Mohammed

AU - Elghetany, Hossam

AU - Medani, Abdel Razak

AU - Yusufali, Afzal Hussein

AU - Al Jassim, Obaid

AU - Al Hallaq, Omar

AU - Baslaib, Fahad Omar Ahmed S.

AU - Amin, Haitham

AU - Al-Waili, Khalid

AU - Al-Rasadi, Khalid

PY - 2022/3/22

Y1 - 2022/3/22

N2 - OBJECTIVES: We sought to estimate the percentage achievements of non-high-density lipoprotein cholesterol (non-HDL-C) target in patients with very high atheroscleroticcardiovascular diseases (ASCVD) risk stratified by triglyceride (TG) levels despite statin-controlled low-density lipoprotein cholesterol (LDL-C) in the Centralized Pan-Middle East Survey on the under treatment of hypercholesterolemia.METHODS: The non-HDL-C target achievement in patients with diabetes mellites (DM) and patients with established ASCVD was defined according to European Society of Cardiology and European Atherosclerosis Society 2019 guidelines for managing dyslipidemia. Patients were stratified to controlled LDL-C defined as < 70 mg/dL (< 1.8 mmol/L) with normal TG < 150 mg/dL (< 1.7 mmol/L) and high TG between 150-400 mg/dL (1.7-4.5 mmol/L).RESULTS: The mean age of our cohort was 58.0±11.0 years, 6.8% (n = 717) were male, 9.7% (104) were smokers, and 48.4% (n = 518) had body mass index of ≥ 30 kg/m 2. Those with high TG levels male (76.5% vs. 63.8%; p < 0.001), smokers (16.1% vs. 7.7%; p < 0.001), have metabolic syndrome (77.6% vs. 17.1%; p < 0.001), and low HDL-C levels (79.2% vs. 49.4%; p < 0.001). The majority (93.9%, n = 1008) were on statins (atorvastatin and rosuvastatin) with only 2.2% (n = 24) on the combined statins plus fenofibrate/gemfibrozil. Only 27.4% (n = 294) of patients had non-HDL-C goal attainment. Goal attainment rates in patients with diabetes (3.1% vs. 34,4%; p < 0.001), coronary artery disease (CAD) (2.4% vs. 37.9%; p < 0.001), diabetes plus CAD (0% vs. 40.0%; p < 0.001), and CVD (0% vs. 30.0%; p = 0.048) were significantly lower in those with higher TG levels. CONCLUSIONS: A large proportion of statin-controlled LDL-C diabetic patients and patients with established ASCVD with high TGs did not achieve the non-HDL-C target. Our study did not demonstrate an association between ASCVD and high TG levels; and therefore, a follow-up study is highly required to assess long-term ASCVD outcomes in this cohort.

AB - OBJECTIVES: We sought to estimate the percentage achievements of non-high-density lipoprotein cholesterol (non-HDL-C) target in patients with very high atheroscleroticcardiovascular diseases (ASCVD) risk stratified by triglyceride (TG) levels despite statin-controlled low-density lipoprotein cholesterol (LDL-C) in the Centralized Pan-Middle East Survey on the under treatment of hypercholesterolemia.METHODS: The non-HDL-C target achievement in patients with diabetes mellites (DM) and patients with established ASCVD was defined according to European Society of Cardiology and European Atherosclerosis Society 2019 guidelines for managing dyslipidemia. Patients were stratified to controlled LDL-C defined as < 70 mg/dL (< 1.8 mmol/L) with normal TG < 150 mg/dL (< 1.7 mmol/L) and high TG between 150-400 mg/dL (1.7-4.5 mmol/L).RESULTS: The mean age of our cohort was 58.0±11.0 years, 6.8% (n = 717) were male, 9.7% (104) were smokers, and 48.4% (n = 518) had body mass index of ≥ 30 kg/m 2. Those with high TG levels male (76.5% vs. 63.8%; p < 0.001), smokers (16.1% vs. 7.7%; p < 0.001), have metabolic syndrome (77.6% vs. 17.1%; p < 0.001), and low HDL-C levels (79.2% vs. 49.4%; p < 0.001). The majority (93.9%, n = 1008) were on statins (atorvastatin and rosuvastatin) with only 2.2% (n = 24) on the combined statins plus fenofibrate/gemfibrozil. Only 27.4% (n = 294) of patients had non-HDL-C goal attainment. Goal attainment rates in patients with diabetes (3.1% vs. 34,4%; p < 0.001), coronary artery disease (CAD) (2.4% vs. 37.9%; p < 0.001), diabetes plus CAD (0% vs. 40.0%; p < 0.001), and CVD (0% vs. 30.0%; p = 0.048) were significantly lower in those with higher TG levels. CONCLUSIONS: A large proportion of statin-controlled LDL-C diabetic patients and patients with established ASCVD with high TGs did not achieve the non-HDL-C target. Our study did not demonstrate an association between ASCVD and high TG levels; and therefore, a follow-up study is highly required to assess long-term ASCVD outcomes in this cohort.

KW - Arabs

KW - Cardiovascular Diseases

KW - Cholesterol

KW - Diabetes Mellitus

KW - LDL

KW - Risk Factors

KW - Triglycerides

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The Achievement of Non-high-density Lipoprotein Cholesterol Target in Patients with Very High Atherosclerotic Cardiovascular Disease Risk Stratified by Triglyceride Levels Despite Statin-controlled Low-density Lipoprotein Cholesterol

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Keywords

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UN SDGs

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