Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil, Marwa Aqarbeh, Dirk Löffler, Bin Shen, Sultan Abo Orabi, Wolfgang Voelter, Hans Jürgen MacHulla

Research output: Contribution to journalArticlepeer-review

6 Citations (Scopus)

Abstract

The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume283
Issue number1
DOIs
Publication statusPublished - Jan 2010

Keywords

  • 2-Nitroimidazole
  • Aminooxy
  • Hypoxia markers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Health, Toxicology and Mutagenesis
  • Nuclear Energy and Engineering
  • Analytical Chemistry

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