Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil, Marwa Aqarbeh, Dirk Löffler, Bin Shen, Sultan Abo Orabi, Wolfgang Voelter, Hans Jürgen MacHulla

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

Original languageEnglish
Pages (from-to)239-243
Number of pages5
JournalJournal of Radioanalytical and Nuclear Chemistry
Volume283
Issue number1
DOIs
Publication statusPublished - Jan 2010

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Oximes
Drug products
Imaging techniques
Pharmaceutical Preparations
Labeling
Tumors
azomycin
Hypoxia
Tumor Hypoxia

Keywords

  • 2-Nitroimidazole
  • Aminooxy
  • Hypoxia markers

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Spectroscopy
  • Public Health, Environmental and Occupational Health
  • Pollution
  • Health, Toxicology and Mutagenesis
  • Nuclear Energy and Engineering
  • Analytical Chemistry

Cite this

Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals. / Abdel-Jalil, Raid J.; Aqarbeh, Marwa; Löffler, Dirk; Shen, Bin; Orabi, Sultan Abo; Voelter, Wolfgang; MacHulla, Hans Jürgen.

In: Journal of Radioanalytical and Nuclear Chemistry, Vol. 283, No. 1, 01.2010, p. 239-243.

Research output: Contribution to journalArticle

Abdel-Jalil, Raid J. ; Aqarbeh, Marwa ; Löffler, Dirk ; Shen, Bin ; Orabi, Sultan Abo ; Voelter, Wolfgang ; MacHulla, Hans Jürgen. / Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals. In: Journal of Radioanalytical and Nuclear Chemistry. 2010 ; Vol. 283, No. 1. pp. 239-243.
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