Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals

Raid J. Abdel-Jalil, Marwa Aqarbeh, Dirk Löffler, Bin Shen, Sultan Abo Orabi, Wolfgang Voelter, Hans Jürgen MacHulla

نتاج البحث: المساهمة في مجلةمراجعة النظراء

8 اقتباسات (Scopus)

ملخص

The synthesis of the three 18F-labeled 2-nitroimidazoyl oximes is described to be used as possible hypoxia tumor imaging agents. The title oximes were successfully synthesized in a four step sequence, characterized, and finally radiolabeled. Under optimized labeling conditions, the radiochemical yields of the three markers were in the range of 69-80%.

اللغة الأصليةEnglish
الصفحات (من إلى)239-243
عدد الصفحات5
دوريةJournal of Radioanalytical and Nuclear Chemistry
مستوى الصوت283
رقم الإصدار1
المعرِّفات الرقمية للأشياء
حالة النشرPublished - يناير 2010
منشور خارجيًانعم

ASJC Scopus subject areas

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  • ???subjectarea.asjc.1600.1607???
  • ???subjectarea.asjc.2700.2739???
  • ???subjectarea.asjc.2300.2307???

بصمة

أدرس بدقة موضوعات البحث “Synthesis and radiolabeling of new N-[(4-[18F]Fluorobenzylidene) aminooxy) alkyl]-2-nitroimidazoles as possible hypoxia imaging pharmaceuticals'. فهما يشكلان معًا بصمة فريدة.

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