Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner, Heather L. Hillebrenner, David R. Adams, Tomas Hudlicky, George R. Pettit

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.

Original languageEnglish
Pages (from-to)2911-2915
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number11
DOIs
Publication statusPublished - Jun 7 2004

Keywords

  • Amaryllidaceae alkaloids
  • Anticancer drugs
  • Enantioselective synthesis
  • Pancratistatin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

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