Synthesis and biological activity of some structural modifications of pancratistatin

Uwe Rinner, Heather L. Hillebrenner, David R. Adams, Tomas Hudlicky, George R. Pettit

Research output: Contribution to journalArticle

79 Citations (Scopus)

Abstract

Structurally modified derivatives of 7-deoxypancratistatin have been synthesized and evaluated in cancer cell line inhibition studies.

Original languageEnglish
Pages (from-to)2911-2915
Number of pages5
JournalBioorganic and Medicinal Chemistry Letters
Volume14
Issue number11
DOIs
Publication statusPublished - Jun 7 2004

Fingerprint

Bioactivity
Cells
Derivatives
Cell Line
Neoplasms
pancratistatin
7-deoxypancratistatin

Keywords

  • Amaryllidaceae alkaloids
  • Anticancer drugs
  • Enantioselective synthesis
  • Pancratistatin

ASJC Scopus subject areas

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmaceutical Science
  • Drug Discovery
  • Clinical Biochemistry
  • Organic Chemistry

Cite this

Synthesis and biological activity of some structural modifications of pancratistatin. / Rinner, Uwe; Hillebrenner, Heather L.; Adams, David R.; Hudlicky, Tomas; Pettit, George R.

In: Bioorganic and Medicinal Chemistry Letters, Vol. 14, No. 11, 07.06.2004, p. 2911-2915.

Research output: Contribution to journalArticle

Rinner, Uwe ; Hillebrenner, Heather L. ; Adams, David R. ; Hudlicky, Tomas ; Pettit, George R. / Synthesis and biological activity of some structural modifications of pancratistatin. In: Bioorganic and Medicinal Chemistry Letters. 2004 ; Vol. 14, No. 11. pp. 2911-2915.
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