Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones

Raid J. Abdel-Jalil, Hani M. Aldoqum, Mikdad T. Ayoub, Wolfgang Voelter

Research output: Contribution to journalArticle

38 Citations (Scopus)

Abstract

A series of new 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones were prepared by the oxidative cyclization of the corresponding 2-arylidineamino-4-fluoro-5-(4-methyl-1-piperazinyl)benzamides. The new quinazolinones were evaluated for their antitumor activity.

Original languageEnglish
Pages (from-to)2061-2070
Number of pages10
JournalHeterocycles
Volume65
Issue number9
DOIs
Publication statusPublished - Sep 1 2005

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Benzamides
Quinazolinones
Cyclization
4-hydroxyquinazoline

ASJC Scopus subject areas

  • Organic Chemistry

Cite this

Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones. / Abdel-Jalil, Raid J.; Aldoqum, Hani M.; Ayoub, Mikdad T.; Voelter, Wolfgang.

In: Heterocycles, Vol. 65, No. 9, 01.09.2005, p. 2061-2070.

Research output: Contribution to journalArticle

Abdel-Jalil, Raid J. ; Aldoqum, Hani M. ; Ayoub, Mikdad T. ; Voelter, Wolfgang. / Synthesis and antitumor activity of 2-aryl-7-fluoro-6-(4-methyl-1-piperazinyl)-4(3H)-quinazolinones. In: Heterocycles. 2005 ; Vol. 65, No. 9. pp. 2061-2070.
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