Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance

Mohammad Dallak, Ismaeel Bin-Jaliah, Hussein F. Sakr, Bahjat Al-Ani, Mohamed A. Haidara

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: We sought to determine whether swim exercise can inhibit high carbohydrate and fat diet (HCFD)-induced biomarkers of coagulation and thrombosis. Material and methods: Rats were either fed with HCFD (model group) or a standard laboratory chow (control group) for 15 weeks. Swim exercise-‘treated’ rats started swim exercise training from the 11th week until being sacrificed, on Week 15. Results: HCFD caused a significant increase in blood glucose, insulin resistance (HOMA-IR), lipidemia, and inflammatory biomarkers. In addition, HCFD significantly modulated coagulation and thrombosis biomarkers; fibrinogen, plasminogen activator inhibitor-1, von Willebrand factor, prothrombin time, activated partial thromboplastin time, blood clotting and bleeding time, and ADP-induced platelet aggregation that was effectively inhibited by swimming exercises. Conclusions: We demonstrate that in an animal model of obesity and insulin resistance, there is a significant change in hemostasis, which is ameliorated by swim exercise.

Original languageEnglish
Pages (from-to)1-6
Number of pages6
JournalArchives of Physiology and Biochemistry
DOIs
Publication statusAccepted/In press - Feb 13 2018

Fingerprint

High Fat Diet
Hemostatics
Insulin Resistance
Obesity
Carbohydrates
Biomarkers
Thrombosis
Bleeding Time
Partial Thromboplastin Time
Plasminogen Activator Inhibitor 1
Prothrombin Time
von Willebrand Factor
Blood Coagulation
Hyperlipidemias
Hemostasis
Platelet Aggregation
Adenosine Diphosphate
Fibrinogen
Blood Glucose
Animal Models

Keywords

  • coagulation
  • exercise
  • insulin resistance
  • Obesity
  • rat model
  • thrombosis

ASJC Scopus subject areas

  • Physiology
  • Physiology (medical)

Cite this

Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance. / Dallak, Mohammad; Bin-Jaliah, Ismaeel; Sakr, Hussein F.; Al-Ani, Bahjat; Haidara, Mohamed A.

In: Archives of Physiology and Biochemistry, 13.02.2018, p. 1-6.

Research output: Contribution to journalArticle

Dallak, Mohammad ; Bin-Jaliah, Ismaeel ; Sakr, Hussein F. ; Al-Ani, Bahjat ; Haidara, Mohamed A. / Swim exercise inhibits hemostatic abnormalities in a rat model of obesity and insulin resistance. In: Archives of Physiology and Biochemistry. 2018 ; pp. 1-6.
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