Successful direct adsorption of lipoproteins (DALI) apheresis during pregnancy in an Omani woman with homozygous familial hypercholesterolemia

Tamima Al-Dughaishi, Khalid Al-Waili, Yajnavalka Banerjee, Shahila Sheik, Hilal Al-Sabti, Ibrahim Al-Zakwani, Suad Al-Mukhaini, Khalifa Al Wahaibi, Ali T. Al-Hinai, Khalid Al-Rasadi

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Abstract

We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.

Original languageEnglish
Pages (from-to)114-117
Number of pages4
JournalOpen Cardiovascular Medicine Journal
Volume9
Publication statusPublished - 2015

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Hyperlipoproteinemia Type II
Blood Component Removal
Lipoproteins
Adsorption
Pregnancy
Carotid Artery Diseases
Aortic Valve Stenosis
Carotid Arteries
LDL Cholesterol
Pregnant Women
Coronary Artery Disease
Therapeutics
Mothers
Newborn Infant

Keywords

  • Familial hypercholesterolemia
  • LDL-apheresis
  • Low density lipoprotein receptor
  • Pregnancy
  • Xanthoma

ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine

Cite this

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abstract = "We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50{\%}. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.",
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author = "Tamima Al-Dughaishi and Khalid Al-Waili and Yajnavalka Banerjee and Shahila Sheik and Hilal Al-Sabti and Ibrahim Al-Zakwani and Suad Al-Mukhaini and {Al Wahaibi}, Khalifa and Al-Hinai, {Ali T.} and Khalid Al-Rasadi",
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T1 - Successful direct adsorption of lipoproteins (DALI) apheresis during pregnancy in an Omani woman with homozygous familial hypercholesterolemia

AU - Al-Dughaishi, Tamima

AU - Al-Waili, Khalid

AU - Banerjee, Yajnavalka

AU - Sheik, Shahila

AU - Al-Sabti, Hilal

AU - Al-Zakwani, Ibrahim

AU - Al-Mukhaini, Suad

AU - Al Wahaibi, Khalifa

AU - Al-Hinai, Ali T.

AU - Al-Rasadi, Khalid

PY - 2015

Y1 - 2015

N2 - We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.

AB - We report our experience with Direct Adsorption of Lipoproteins (DALI) apheresis in an Omani pregnant woman affected by homozygous familial hypercholesterolemia. To the best of our knowledge this is the first successful pregnancy treated with DALI apheresis. The patient had a history of coronary artery disease, supra-aortic valvular stenosis and severe carotid artery disease with right carotid artery stenting. She was on a regular biweekly DALI apheresis since 2008. In May 2013, she became pregnant and rosuvastatin and ezetimibe were stopped while she continued on DALI apheresis biweekly. This treatment during pregnancy was successful with no major complications. The average low-density lipoprotein cholesterol reduction during therapy was 50%. She spontaneously delivered a healthy male infant (2,400 g) at 37 weeks. We showed that DALI apheresis therapy was safe during pregnancy with a good outcome for both mother and neonate.

KW - Familial hypercholesterolemia

KW - LDL-apheresis

KW - Low density lipoprotein receptor

KW - Pregnancy

KW - Xanthoma

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