Subcutaneous fat pads on body MRI - An early sign of congenital disorder of glycosylation PMM2-CDG (CDG1a)

Almundher A. Al-Maawali, Elka Miller, Andreas Schulze, Grace Yoon, Susan I. Blaser

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Infants with phosphomannomutase 2 - congenital disorder of glycosylation (PMM2-CDG), formerly known as CDG1a, present with failure to thrive, visceral dysfunction, thromboembolic events and developmental delays noted before 6 months of age. Diagnosis is often delayed due to the considerable variability in phenotype. Characteristic, but not universal, features include inverted nipples and abnormal subcutaneous fat pads. Neuroimaging performed in the first 4 months of life may be normal, although cerebellar and brainstem atrophy is usual after 3 months of age. Cerebellar and brainstem atrophy have been noted as early as 11 days of life. We present an infant whose typical subcutaneous and retroperitoneal fat deposits were clinically occult, but identified on body MRI.

Original languageEnglish
Pages (from-to)222-225
Number of pages4
JournalPediatric Radiology
Volume44
Issue number2
DOIs
Publication statusPublished - Feb 2014

Keywords

  • CDG1a
  • Congenital disorder of glycosylation (PMM2-CDG)
  • Congenital disorders of glycosylation
  • Infant
  • Jaeken syndrome
  • phosphomannomutase 2
  • Subcutaneous fat deposits

ASJC Scopus subject areas

  • Radiology Nuclear Medicine and imaging
  • Pediatrics, Perinatology, and Child Health

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