Subcutaneous administration of testosterone. A pilot study report

Abdullah M. Al-Futaisi, Ibrahim S. Al-Zakwani, Abdulaziz M. Almahrezi, David Morris

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Objective: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. Methods: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Cananda, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administered weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. Results: A total of 22 patients were enrolled in the study. The mean trough was 14.48 ± 3.14 nmol/L and peak total testosterone was 21.65 ± 7.32 nmol/L. For the free and the peak was 85.17 ± 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. Conclusion: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and through levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.

Original languageEnglish
Pages (from-to)1843-1846
Number of pages4
JournalSaudi Medical Journal
Volume27
Issue number12
Publication statusPublished - Dec 2006

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Testosterone
Hypogonadism
Victoria
Quebec
Syringes
Reference Values
Insulin
Therapeutics
Serum

ASJC Scopus subject areas

  • Medicine(all)

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Subcutaneous administration of testosterone. A pilot study report. / Al-Futaisi, Abdullah M.; Al-Zakwani, Ibrahim S.; Almahrezi, Abdulaziz M.; Morris, David.

In: Saudi Medical Journal, Vol. 27, No. 12, 12.2006, p. 1843-1846.

Research output: Contribution to journalArticle

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N2 - Objective: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. Methods: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Cananda, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administered weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. Results: A total of 22 patients were enrolled in the study. The mean trough was 14.48 ± 3.14 nmol/L and peak total testosterone was 21.65 ± 7.32 nmol/L. For the free and the peak was 85.17 ± 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. Conclusion: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and through levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.

AB - Objective: To investigate the effect of low doses of subcutaneous testosterone in hypogonadal men since the intramuscular route, which is the most widely used form of testosterone replacement therapy, is inconvenient to many patients. Methods: All men with primary and secondary hypogonadism attending the reproductive endocrine clinic at Royal Victoria Hospital, Montreal, Quebec, Cananda, were invited to participate in the study. Subjects were enrolled from January 2002 till December 2002. Patients were asked to self-administered weekly low doses of testosterone enanthate using 0.5 ml insulin syringe. Results: A total of 22 patients were enrolled in the study. The mean trough was 14.48 ± 3.14 nmol/L and peak total testosterone was 21.65 ± 7.32 nmol/L. For the free and the peak was 85.17 ± 32.88 pmol/L. All of the patients delivered testosterone with ease and no local reactions were reported. Conclusion: Therapy with weekly subcutaneous testosterone produced serum levels that were within the normal range in 100% of patients for both peak and through levels. This is the first report, which demonstrated the efficacy of delivering weekly testosterone using this cheap, safe, and less painful subcutaneous route.

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