Abstract
3-Naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline (NPFP), a fluorogenic probe and its derivative NPFP-Phenylephrine were synthesized and their absorption and fluorescence properties were recorded in solvents of varying polarity. Spectroscopic studies reveal that, the solvatochromic behavior of the compounds depend not only on the polarity but also on the hydrogen-bonding properties of the solvents. The effects of β-cyclodextrin on the fluorescence properties of both compounds were studied. It was found that there is an enhancement in the fluorescence intensity of labeled drug (NPFP-Phenylephrine) in the presence of β-cyclodextrin. In the present study, the molecular motions of NPFP-Phenylephrine embedded in a β-cyclodextrin cavity have been investigated by fluorescence techniques in steady-state and time resolved modes.
| Original language | English |
|---|---|
| Pages (from-to) | 661-671 |
| Number of pages | 11 |
| Journal | Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy |
| Volume | 136 |
| Issue number | PB |
| DOIs | |
| Publication status | Published - Feb 5 2015 |
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Keywords
- Charge-transfer character
- Fluorescence anisotropy
- Pyrazoline
- Solvent effect
- Synthesis
- β-cyclodextrin
ASJC Scopus subject areas
- Instrumentation
- Atomic and Molecular Physics, and Optics
- Analytical Chemistry
- Spectroscopy
- Medicine(all)
Cite this
Study on the spectral and inclusion properties of a sensitive dye, 3-naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline, in solvents and β-cyclodextrin. / Varghese, Beena; Al-Busafi, Saleh N.; Suliman, Fakhreldin O.; Al-Kindy, Salma M Z.
In: Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy, Vol. 136, No. PB, 05.02.2015, p. 661-671.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Study on the spectral and inclusion properties of a sensitive dye, 3-naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline, in solvents and β-cyclodextrin
AU - Varghese, Beena
AU - Al-Busafi, Saleh N.
AU - Suliman, Fakhreldin O.
AU - Al-Kindy, Salma M Z
PY - 2015/2/5
Y1 - 2015/2/5
N2 - 3-Naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline (NPFP), a fluorogenic probe and its derivative NPFP-Phenylephrine were synthesized and their absorption and fluorescence properties were recorded in solvents of varying polarity. Spectroscopic studies reveal that, the solvatochromic behavior of the compounds depend not only on the polarity but also on the hydrogen-bonding properties of the solvents. The effects of β-cyclodextrin on the fluorescence properties of both compounds were studied. It was found that there is an enhancement in the fluorescence intensity of labeled drug (NPFP-Phenylephrine) in the presence of β-cyclodextrin. In the present study, the molecular motions of NPFP-Phenylephrine embedded in a β-cyclodextrin cavity have been investigated by fluorescence techniques in steady-state and time resolved modes.
AB - 3-Naphthyl-1-phenyl-5-(5-fluoro-2-nitrophenyl)-2-pyrazoline (NPFP), a fluorogenic probe and its derivative NPFP-Phenylephrine were synthesized and their absorption and fluorescence properties were recorded in solvents of varying polarity. Spectroscopic studies reveal that, the solvatochromic behavior of the compounds depend not only on the polarity but also on the hydrogen-bonding properties of the solvents. The effects of β-cyclodextrin on the fluorescence properties of both compounds were studied. It was found that there is an enhancement in the fluorescence intensity of labeled drug (NPFP-Phenylephrine) in the presence of β-cyclodextrin. In the present study, the molecular motions of NPFP-Phenylephrine embedded in a β-cyclodextrin cavity have been investigated by fluorescence techniques in steady-state and time resolved modes.
KW - Charge-transfer character
KW - Fluorescence anisotropy
KW - Pyrazoline
KW - Solvent effect
KW - Synthesis
KW - β-cyclodextrin
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UR - http://www.scopus.com/inward/citedby.url?scp=84911911802&partnerID=8YFLogxK
U2 - 10.1016/j.saa.2014.09.080
DO - 10.1016/j.saa.2014.09.080
M3 - Article
C2 - 25448966
AN - SCOPUS:84911911802
VL - 136
SP - 661
EP - 671
JO - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
JF - Spectrochimica Acta - Part A: Molecular and Biomolecular Spectroscopy
SN - 1386-1425
IS - PB
ER -