Spectrum of AIDS defining opportunistic infections in a series of 77 hospitalised HIV-infected Omani patients

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives: Most of the morbidity and mortality in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) result from opportunistic infections (OIs). Although the spectrum of OIs in HIV infected patients from developing countries has been reported, there is a paucity of data on the natural history, pattern of disease, and survival of hospitalised patients with HIV/AIDS, particularly in Arab countries. The aim of this study was to study retrospectively the spectrum and frequency of various OIs in a cohort of hospitalised HIV-infected Omani patients. Methods: Included in the study were 77 HIV-infected Omani patients admitted to a tertiary care teaching hospital in Muscat, Oman, between January 1999 and December 2008. They were diagnosed on their first admission and hence were not on highly active antiretroviral therapy (HAART) at presentation. The frequency of various clinical and laboratory findings and individual OIs were analysed. Results: In total, 45 patients (58%) had one or more AIDS-defining OIs. Pneumocystis jiroveci pneumonia (PCP) was commonest (25%), followed by cryptococcal meningitis (22%), cytomegalovirus (CMV), retinitis (17%), disseminated tuberculosis (15%), and cerebral toxoplasmosis (12.5%). Only one patient with Mycobacterium avium-intracellulare (MAI) was identified and one patient had disseminated visceral leishmaniasis. The majority of patients (77%) had CD4+ counts

Original languageEnglish
Pages (from-to)442-448
Number of pages7
JournalSultan Qaboos University Medical Journal
Volume12
Issue number4
Publication statusPublished - Nov 2012

Fingerprint

Opportunistic Infections
Acquired Immunodeficiency Syndrome
HIV
Cerebral Toxoplasmosis
Oman
Cytomegalovirus Retinitis
Cryptococcal Meningitis
Pneumocystis carinii
Mycobacterium avium Complex
Pneumocystis Pneumonia
Middle East
Visceral Leishmaniasis
Highly Active Antiretroviral Therapy
Tertiary Healthcare
CD4 Lymphocyte Count
Natural History
Teaching Hospitals
Developing Countries
Tuberculosis
Morbidity

Keywords

  • AIDS
  • HIV
  • Oman
  • Opportunistic infections

ASJC Scopus subject areas

  • Medicine(all)

Cite this

@article{149c34054b4848408cca35277901c060,
title = "Spectrum of AIDS defining opportunistic infections in a series of 77 hospitalised HIV-infected Omani patients",
abstract = "Objectives: Most of the morbidity and mortality in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) result from opportunistic infections (OIs). Although the spectrum of OIs in HIV infected patients from developing countries has been reported, there is a paucity of data on the natural history, pattern of disease, and survival of hospitalised patients with HIV/AIDS, particularly in Arab countries. The aim of this study was to study retrospectively the spectrum and frequency of various OIs in a cohort of hospitalised HIV-infected Omani patients. Methods: Included in the study were 77 HIV-infected Omani patients admitted to a tertiary care teaching hospital in Muscat, Oman, between January 1999 and December 2008. They were diagnosed on their first admission and hence were not on highly active antiretroviral therapy (HAART) at presentation. The frequency of various clinical and laboratory findings and individual OIs were analysed. Results: In total, 45 patients (58{\%}) had one or more AIDS-defining OIs. Pneumocystis jiroveci pneumonia (PCP) was commonest (25{\%}), followed by cryptococcal meningitis (22{\%}), cytomegalovirus (CMV), retinitis (17{\%}), disseminated tuberculosis (15{\%}), and cerebral toxoplasmosis (12.5{\%}). Only one patient with Mycobacterium avium-intracellulare (MAI) was identified and one patient had disseminated visceral leishmaniasis. The majority of patients (77{\%}) had CD4+ counts",
keywords = "AIDS, HIV, Oman, Opportunistic infections",
author = "Balkhair, {Abdullah A.} and Al-Muharrmi, {Zakariya K.} and Shyam Ganguly and Al-Jabri, {Ali A.}",
year = "2012",
month = "11",
language = "English",
volume = "12",
pages = "442--448",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "4",

}

TY - JOUR

T1 - Spectrum of AIDS defining opportunistic infections in a series of 77 hospitalised HIV-infected Omani patients

AU - Balkhair, Abdullah A.

AU - Al-Muharrmi, Zakariya K.

AU - Ganguly, Shyam

AU - Al-Jabri, Ali A.

PY - 2012/11

Y1 - 2012/11

N2 - Objectives: Most of the morbidity and mortality in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) result from opportunistic infections (OIs). Although the spectrum of OIs in HIV infected patients from developing countries has been reported, there is a paucity of data on the natural history, pattern of disease, and survival of hospitalised patients with HIV/AIDS, particularly in Arab countries. The aim of this study was to study retrospectively the spectrum and frequency of various OIs in a cohort of hospitalised HIV-infected Omani patients. Methods: Included in the study were 77 HIV-infected Omani patients admitted to a tertiary care teaching hospital in Muscat, Oman, between January 1999 and December 2008. They were diagnosed on their first admission and hence were not on highly active antiretroviral therapy (HAART) at presentation. The frequency of various clinical and laboratory findings and individual OIs were analysed. Results: In total, 45 patients (58%) had one or more AIDS-defining OIs. Pneumocystis jiroveci pneumonia (PCP) was commonest (25%), followed by cryptococcal meningitis (22%), cytomegalovirus (CMV), retinitis (17%), disseminated tuberculosis (15%), and cerebral toxoplasmosis (12.5%). Only one patient with Mycobacterium avium-intracellulare (MAI) was identified and one patient had disseminated visceral leishmaniasis. The majority of patients (77%) had CD4+ counts

AB - Objectives: Most of the morbidity and mortality in human immunodeficiency virus/acquired immune deficiency syndrome (HIV/AIDS) result from opportunistic infections (OIs). Although the spectrum of OIs in HIV infected patients from developing countries has been reported, there is a paucity of data on the natural history, pattern of disease, and survival of hospitalised patients with HIV/AIDS, particularly in Arab countries. The aim of this study was to study retrospectively the spectrum and frequency of various OIs in a cohort of hospitalised HIV-infected Omani patients. Methods: Included in the study were 77 HIV-infected Omani patients admitted to a tertiary care teaching hospital in Muscat, Oman, between January 1999 and December 2008. They were diagnosed on their first admission and hence were not on highly active antiretroviral therapy (HAART) at presentation. The frequency of various clinical and laboratory findings and individual OIs were analysed. Results: In total, 45 patients (58%) had one or more AIDS-defining OIs. Pneumocystis jiroveci pneumonia (PCP) was commonest (25%), followed by cryptococcal meningitis (22%), cytomegalovirus (CMV), retinitis (17%), disseminated tuberculosis (15%), and cerebral toxoplasmosis (12.5%). Only one patient with Mycobacterium avium-intracellulare (MAI) was identified and one patient had disseminated visceral leishmaniasis. The majority of patients (77%) had CD4+ counts

KW - AIDS

KW - HIV

KW - Oman

KW - Opportunistic infections

UR - http://www.scopus.com/inward/record.url?scp=84870704462&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84870704462&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84870704462

VL - 12

SP - 442

EP - 448

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 4

ER -