Soft tissue Rosai-Dorfman disease: Case report

Rubyath C. Rajib*, Rajasekharan Pillai, Ibrahim A. Sulaiman, Ibrahim Al-Haddabi

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (SciVal)


Rosai-Dorfman disease (RDD) is a rare benign proliferative histiocytic disorder characterised by massive lymphadenopathy. While extranodal involvement can occur in generalised RDD, isolated soft tissue RDD (STRDD) is extremely rare. We report a 17-year-old male patient who presented to the maxillofacial outpatient department of the Sultan Qaboos Hospital, Salalah, Oman, in 2015 with a painless cheek mass which had been slowly growing over the previous two months. Routine histopathological examinations and immunohistochemistry confirmed a diagnosis of STRDD. Currently, surgical excision is considered to be the most effective curative treatment for STRDD, as the outcomes of other treatment modalities are still unknown. Despite its rarity, STRDD should be considered in the differential diagnosis of histiocytic soft tissue lesions.

Original languageEnglish
Pages (from-to)e452-e454
JournalSultan Qaboos University Medical Journal
Issue number4
Publication statusPublished - Nov 2017


  • Case report
  • Emperipolesis
  • Histiocytosis
  • Oman
  • Rosai-Dorfman disease
  • S100 proteins

ASJC Scopus subject areas

  • Medicine(all)


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