Secondary malignant melanoma in primary mediastinal germ cell tumour

Abdul Hannan*, Noreen Akhter, Ather Saeed Kazmi, Narjis Muzaffar

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

2 Citations (Scopus)


Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.

Original languageEnglish
Pages (from-to)98-100
Number of pages3
JournalJournal of the Pakistan Medical Association
Issue number1
Publication statusPublished - 2015
Externally publishedYes


  • Extragonadal germ cell tumour
  • Malignant
  • Mediastinal
  • Melanoma
  • Teratoma

ASJC Scopus subject areas

  • Medicine(all)


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