Abstract
Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
| Original language | English |
|---|---|
| Pages (from-to) | 98-100 |
| Number of pages | 3 |
| Journal | Journal of the Pakistan Medical Association |
| Volume | 65 |
| Issue number | 1 |
| Publication status | Published - 2015 |
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Keywords
- Extragonadal germ cell tumour
- Malignant
- Mediastinal
- Melanoma
- Teratoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Secondary malignant melanoma in primary mediastinal germ cell tumour. / Hannan, Abdul; Akhter, Noreen; Kazmi, Ather Saeed; Muzaffar, Narjis.
In: Journal of the Pakistan Medical Association, Vol. 65, No. 1, 2015, p. 98-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Secondary malignant melanoma in primary mediastinal germ cell tumour
AU - Hannan, Abdul
AU - Akhter, Noreen
AU - Kazmi, Ather Saeed
AU - Muzaffar, Narjis
PY - 2015
Y1 - 2015
N2 - Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
AB - Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
KW - Extragonadal germ cell tumour
KW - Malignant
KW - Mediastinal
KW - Melanoma
KW - Teratoma
UR - http://www.scopus.com/inward/record.url?scp=84928060405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928060405&partnerID=8YFLogxK
M3 - Article
C2 - 25831688
AN - SCOPUS:84928060405
VL - 65
SP - 98
EP - 100
JO - JPMA. The Journal of the Pakistan Medical Association
JF - JPMA. The Journal of the Pakistan Medical Association
SN - 0030-9982
IS - 1
ER -