Abstract
Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
Original language | English |
---|---|
Pages (from-to) | 98-100 |
Number of pages | 3 |
Journal | Journal of the Pakistan Medical Association |
Volume | 65 |
Issue number | 1 |
Publication status | Published - 2015 |
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Keywords
- Extragonadal germ cell tumour
- Malignant
- Mediastinal
- Melanoma
- Teratoma
ASJC Scopus subject areas
- Medicine(all)
Cite this
Secondary malignant melanoma in primary mediastinal germ cell tumour. / Hannan, Abdul; Akhter, Noreen; Kazmi, Ather Saeed; Muzaffar, Narjis.
In: Journal of the Pakistan Medical Association, Vol. 65, No. 1, 2015, p. 98-100.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Secondary malignant melanoma in primary mediastinal germ cell tumour
AU - Hannan, Abdul
AU - Akhter, Noreen
AU - Kazmi, Ather Saeed
AU - Muzaffar, Narjis
PY - 2015
Y1 - 2015
N2 - Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
AB - Secondary transformation in Germ Cell Tumours (GCT) is an extremely rare event. We report here a case of malignant melanoma arising in primary mediastinal GCT. A young male presented with new onset dyspnoea and a mediastinal mass. As serum alpha fetoprotein was raised, a diagnosis of primary mediastinal GCT was made. He achieved remission with standard chemotherapy and resection of the mass. After a year, he relapsed with widespread disease which on work-up revealed malignant melanoma. As examination for cutaneous melanoma was unremarkable, a diagnosis of mediastinal GCT with secondary transformation to melanoma was made. Exact origin of melanoma in GCTs is unknown, but these may occur from transformation of dermal elements or de-differentiation of germ cells to melanomas. Before making such a diagnosis, search for primary cutaneous melanoma is mandatory. No clear guidelines exist in literature for the treatment of secondary melanomas, so current management guidelines for cutaneous melanoma may be followed.
KW - Extragonadal germ cell tumour
KW - Malignant
KW - Mediastinal
KW - Melanoma
KW - Teratoma
UR - http://www.scopus.com/inward/record.url?scp=84928060405&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=84928060405&partnerID=8YFLogxK
M3 - Article
C2 - 25831688
AN - SCOPUS:84928060405
VL - 65
SP - 98
EP - 100
JO - JPMA. The Journal of the Pakistan Medical Association
JF - JPMA. The Journal of the Pakistan Medical Association
SN - 0030-9982
IS - 1
ER -