Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease

R. Nandhagopal, Andre R. Troiano, Edwin Mak, Michael Schulzer, Mary Catherine Bushnell, Alexander Jon Stoessl

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Background: Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective: The aim of this study is to assess thermal experience and emotional content, as well as side-to-side sensory differences in PD " off" and " on" dopaminergic therapy following thermal cutaneous stimulation. Design: Cross-sectional design. Setting: University teaching hospital. Methods: Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results: There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions: These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain. Wiley Periodicals, Inc.

Original languageEnglish
Pages (from-to)834-840
Number of pages7
JournalPain Medicine
Volume11
Issue number6
DOIs
Publication statusPublished - Jun 2010

Fingerprint

Parkinson Disease
Hot Temperature
Pain
Pain Perception
Visual Analog Scale
Teaching Hospitals
Dopamine
Skin

Keywords

  • Heat Pain
  • Medication Status
  • Parkinson's Disease
  • Unpleasantness

ASJC Scopus subject areas

  • Clinical Neurology
  • Anesthesiology and Pain Medicine
  • Medicine(all)

Cite this

Nandhagopal, R., Troiano, A. R., Mak, E., Schulzer, M., Bushnell, M. C., & Stoessl, A. J. (2010). Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease. Pain Medicine, 11(6), 834-840. https://doi.org/10.1111/j.1526-4637.2010.00866.x

Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease. / Nandhagopal, R.; Troiano, Andre R.; Mak, Edwin; Schulzer, Michael; Bushnell, Mary Catherine; Stoessl, Alexander Jon.

In: Pain Medicine, Vol. 11, No. 6, 06.2010, p. 834-840.

Research output: Contribution to journalArticle

Nandhagopal, R, Troiano, AR, Mak, E, Schulzer, M, Bushnell, MC & Stoessl, AJ 2010, 'Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease', Pain Medicine, vol. 11, no. 6, pp. 834-840. https://doi.org/10.1111/j.1526-4637.2010.00866.x
Nandhagopal, R. ; Troiano, Andre R. ; Mak, Edwin ; Schulzer, Michael ; Bushnell, Mary Catherine ; Stoessl, Alexander Jon. / Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease. In: Pain Medicine. 2010 ; Vol. 11, No. 6. pp. 834-840.
@article{58a653174a1d4a329d157d55fff459ef,
title = "Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease",
abstract = "Background: Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective: The aim of this study is to assess thermal experience and emotional content, as well as side-to-side sensory differences in PD {"} off{"} and {"} on{"} dopaminergic therapy following thermal cutaneous stimulation. Design: Cross-sectional design. Setting: University teaching hospital. Methods: Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results: There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions: These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain. Wiley Periodicals, Inc.",
keywords = "Heat Pain, Medication Status, Parkinson's Disease, Unpleasantness",
author = "R. Nandhagopal and Troiano, {Andre R.} and Edwin Mak and Michael Schulzer and Bushnell, {Mary Catherine} and Stoessl, {Alexander Jon}",
year = "2010",
month = "6",
doi = "10.1111/j.1526-4637.2010.00866.x",
language = "English",
volume = "11",
pages = "834--840",
journal = "Pain Medicine",
issn = "1526-2375",
publisher = "Wiley-Blackwell",
number = "6",

}

TY - JOUR

T1 - Response to Heat Pain Stimulation in Idiopathic Parkinson's Disease

AU - Nandhagopal, R.

AU - Troiano, Andre R.

AU - Mak, Edwin

AU - Schulzer, Michael

AU - Bushnell, Mary Catherine

AU - Stoessl, Alexander Jon

PY - 2010/6

Y1 - 2010/6

N2 - Background: Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective: The aim of this study is to assess thermal experience and emotional content, as well as side-to-side sensory differences in PD " off" and " on" dopaminergic therapy following thermal cutaneous stimulation. Design: Cross-sectional design. Setting: University teaching hospital. Methods: Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results: There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions: These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain. Wiley Periodicals, Inc.

AB - Background: Pain is a prominent nonmotor symptom in Parkinson's disease (PD) but has not been well studied. Objective: The aim of this study is to assess thermal experience and emotional content, as well as side-to-side sensory differences in PD " off" and " on" dopaminergic therapy following thermal cutaneous stimulation. Design: Cross-sectional design. Setting: University teaching hospital. Methods: Twelve PD subjects experiencing motor fluctuations but no pain symptoms and 13 healthy controls participated in the study. Heat pain and emotional content were assessed using a thermode and visual analog scales in medication on and off states in PD and without medication in healthy controls. Results: There were no side to side differences in heat pain intensity or between PD medication on state and PD medication off state. Unexpectedly, PD subjects reported a higher degree of unpleasantness in response to heat pain while on medication compared with the off state. Conclusions: These results suggest that the perception of heat pain is mediated, at least in part, by nondopaminergic systems in PD, while dopamine might modulate the affective component of pain. Wiley Periodicals, Inc.

KW - Heat Pain

KW - Medication Status

KW - Parkinson's Disease

KW - Unpleasantness

UR - http://www.scopus.com/inward/record.url?scp=77954438430&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77954438430&partnerID=8YFLogxK

U2 - 10.1111/j.1526-4637.2010.00866.x

DO - 10.1111/j.1526-4637.2010.00866.x

M3 - Article

C2 - 20624238

AN - SCOPUS:77954438430

VL - 11

SP - 834

EP - 840

JO - Pain Medicine

JF - Pain Medicine

SN - 1526-2375

IS - 6

ER -