Quantitative and qualitative corneal endothelial morphology of Omani patients with pseudoexfoliation syndrome

Upender K. Wali, Abdullah S. Al-Mujaini, Nadia S. Al-Kharusi, Alexander A. Bialasiewicz, Syed G. Rizvi

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Objective: Pseudoexfoliation (PEX) syndrome is one of the leading causes of secondary open angle glaucoma and blindness. This study explored whether in PEX eyes, preoperative changes in corneal endothelial cell morphology might be a risk factor for postoperative corneal decompensation. Methods: One hundred twenty six eyes of 69 preoperative cataract patients (43 males, 26 females) were enrolled in this cross-sectional study from the Ophthalmology Department at Sultan Qaboos University Hospital between 2003-2005. All patients were subjected to confocal biomicroscopy. Results: The mean age of patients with PEX eyes was 63.2 years. One hundred and eight (85.7%) eyes with PEX had endothelial cell counts within the normal range (1650-3500/mm²). The qualitative morphology of the endothelium of PEX corneas was highly abnormal in term of polymegathism and pleomorphism. Twelve eyes had endothelial cell counts higher than normal for that age group. Only 6 eyes had endothelial cell counts lower than normal. The mean value for the pleomorphism was found to be significantly lower than normal and for polymegathism significantly more than normal. The relationship between pleomorphism and polymegathism was stronger for males than for females and stronger for patients under 60 years than patients over 60 years. The same relationship between pleomorphism and polymegathism showed a stronger relationship for the glaucoma group as compared to the non-glaucoma group. Conclusion: This study revealed that corneal decompensation in PEX eyes can occur in presence of abnormalities in polymegathism and pleomorphism, even when the endothelial cell counts may be normal.

Original languageEnglish
Pages (from-to)300-305
Number of pages6
JournalSultan Qaboos University Medical Journal
Volume8
Issue number3
Publication statusPublished - Nov 1 2008

Fingerprint

Exfoliation Syndrome
Endothelial Cells
Cell Count
Open Angle Glaucoma
Ophthalmology
Blindness
Glaucoma
Cornea
Cataract
Endothelium
Reference Values
Age Groups
Cross-Sectional Studies

Keywords

  • Confoscan
  • Pleomorphism
  • Polymegathism
  • Pseudoexfoliation

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Quantitative and qualitative corneal endothelial morphology of Omani patients with pseudoexfoliation syndrome. / Wali, Upender K.; Al-Mujaini, Abdullah S.; Al-Kharusi, Nadia S.; Bialasiewicz, Alexander A.; Rizvi, Syed G.

In: Sultan Qaboos University Medical Journal, Vol. 8, No. 3, 01.11.2008, p. 300-305.

Research output: Contribution to journalArticle

@article{84a2e9ba2b5b4c65b8deb0578f79d571,
title = "Quantitative and qualitative corneal endothelial morphology of Omani patients with pseudoexfoliation syndrome",
abstract = "Objective: Pseudoexfoliation (PEX) syndrome is one of the leading causes of secondary open angle glaucoma and blindness. This study explored whether in PEX eyes, preoperative changes in corneal endothelial cell morphology might be a risk factor for postoperative corneal decompensation. Methods: One hundred twenty six eyes of 69 preoperative cataract patients (43 males, 26 females) were enrolled in this cross-sectional study from the Ophthalmology Department at Sultan Qaboos University Hospital between 2003-2005. All patients were subjected to confocal biomicroscopy. Results: The mean age of patients with PEX eyes was 63.2 years. One hundred and eight (85.7{\%}) eyes with PEX had endothelial cell counts within the normal range (1650-3500/mm²). The qualitative morphology of the endothelium of PEX corneas was highly abnormal in term of polymegathism and pleomorphism. Twelve eyes had endothelial cell counts higher than normal for that age group. Only 6 eyes had endothelial cell counts lower than normal. The mean value for the pleomorphism was found to be significantly lower than normal and for polymegathism significantly more than normal. The relationship between pleomorphism and polymegathism was stronger for males than for females and stronger for patients under 60 years than patients over 60 years. The same relationship between pleomorphism and polymegathism showed a stronger relationship for the glaucoma group as compared to the non-glaucoma group. Conclusion: This study revealed that corneal decompensation in PEX eyes can occur in presence of abnormalities in polymegathism and pleomorphism, even when the endothelial cell counts may be normal.",
keywords = "Confoscan, Pleomorphism, Polymegathism, Pseudoexfoliation",
author = "Wali, {Upender K.} and Al-Mujaini, {Abdullah S.} and Al-Kharusi, {Nadia S.} and Bialasiewicz, {Alexander A.} and Rizvi, {Syed G.}",
year = "2008",
month = "11",
day = "1",
language = "English",
volume = "8",
pages = "300--305",
journal = "Sultan Qaboos University Medical Journal",
issn = "2075-051X",
publisher = "Sultan Qaboos University",
number = "3",

}

TY - JOUR

T1 - Quantitative and qualitative corneal endothelial morphology of Omani patients with pseudoexfoliation syndrome

AU - Wali, Upender K.

AU - Al-Mujaini, Abdullah S.

AU - Al-Kharusi, Nadia S.

AU - Bialasiewicz, Alexander A.

AU - Rizvi, Syed G.

PY - 2008/11/1

Y1 - 2008/11/1

N2 - Objective: Pseudoexfoliation (PEX) syndrome is one of the leading causes of secondary open angle glaucoma and blindness. This study explored whether in PEX eyes, preoperative changes in corneal endothelial cell morphology might be a risk factor for postoperative corneal decompensation. Methods: One hundred twenty six eyes of 69 preoperative cataract patients (43 males, 26 females) were enrolled in this cross-sectional study from the Ophthalmology Department at Sultan Qaboos University Hospital between 2003-2005. All patients were subjected to confocal biomicroscopy. Results: The mean age of patients with PEX eyes was 63.2 years. One hundred and eight (85.7%) eyes with PEX had endothelial cell counts within the normal range (1650-3500/mm²). The qualitative morphology of the endothelium of PEX corneas was highly abnormal in term of polymegathism and pleomorphism. Twelve eyes had endothelial cell counts higher than normal for that age group. Only 6 eyes had endothelial cell counts lower than normal. The mean value for the pleomorphism was found to be significantly lower than normal and for polymegathism significantly more than normal. The relationship between pleomorphism and polymegathism was stronger for males than for females and stronger for patients under 60 years than patients over 60 years. The same relationship between pleomorphism and polymegathism showed a stronger relationship for the glaucoma group as compared to the non-glaucoma group. Conclusion: This study revealed that corneal decompensation in PEX eyes can occur in presence of abnormalities in polymegathism and pleomorphism, even when the endothelial cell counts may be normal.

AB - Objective: Pseudoexfoliation (PEX) syndrome is one of the leading causes of secondary open angle glaucoma and blindness. This study explored whether in PEX eyes, preoperative changes in corneal endothelial cell morphology might be a risk factor for postoperative corneal decompensation. Methods: One hundred twenty six eyes of 69 preoperative cataract patients (43 males, 26 females) were enrolled in this cross-sectional study from the Ophthalmology Department at Sultan Qaboos University Hospital between 2003-2005. All patients were subjected to confocal biomicroscopy. Results: The mean age of patients with PEX eyes was 63.2 years. One hundred and eight (85.7%) eyes with PEX had endothelial cell counts within the normal range (1650-3500/mm²). The qualitative morphology of the endothelium of PEX corneas was highly abnormal in term of polymegathism and pleomorphism. Twelve eyes had endothelial cell counts higher than normal for that age group. Only 6 eyes had endothelial cell counts lower than normal. The mean value for the pleomorphism was found to be significantly lower than normal and for polymegathism significantly more than normal. The relationship between pleomorphism and polymegathism was stronger for males than for females and stronger for patients under 60 years than patients over 60 years. The same relationship between pleomorphism and polymegathism showed a stronger relationship for the glaucoma group as compared to the non-glaucoma group. Conclusion: This study revealed that corneal decompensation in PEX eyes can occur in presence of abnormalities in polymegathism and pleomorphism, even when the endothelial cell counts may be normal.

KW - Confoscan

KW - Pleomorphism

KW - Polymegathism

KW - Pseudoexfoliation

UR - http://www.scopus.com/inward/record.url?scp=84880961016&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84880961016&partnerID=8YFLogxK

M3 - Article

AN - SCOPUS:84880961016

VL - 8

SP - 300

EP - 305

JO - Sultan Qaboos University Medical Journal

JF - Sultan Qaboos University Medical Journal

SN - 2075-051X

IS - 3

ER -