Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA

T. Hirano, H. Otake, I. Yoshida, K. Endo, L. M. Lamki

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

To assess the clinical role of 99mTc(V)-DMSA in primary lung cancers, SPECT imaging was performed on 31 patients with suspected lung cancer. Methods: Planar and SPECT images were obtained at 3 to 4 hr after intravenous injection of approximately 555 MBq 99mTc(V)-DMSA. Two uptake ratios (the maximum counts/pixel in the lesion to the average counts in normal tissue) were calculated. Results: Various types of primary lung cancers (adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell carcinoma and bronchial carcinoid tumor) were imaged by 99mTc(V)-DMSA SPECT. Approximately 90% of the lung carcinomas showed increased uptake and were clearly demonstrated by SPECT images. Four cases incidentally revealed osseous metastatic lesion. Three benign lesions did not show increased uptake. Three cases were false-negative and there were no false-positive cases for the primary lesions. Conclusion: Technetium-99m(V)-DMSA SPECT images demonstrated approximately 90% of the primary lung cancers. Uptake ratios were higher in squamous-cell carcinomas than adenocarcinomas. Evaluation of mediastinal tumor extension and nodal metastatic lesion was very difficult by high blood-pool activity in the major cardiovascular structures due to slow blood-pool clearance. However, 99mTc(V)-DMSA SPECT imaging was very useful for detecting primary lung cancers and metastatic lesions to the osseous structures.

Original languageEnglish
Pages (from-to)202-210
Number of pages9
JournalJournal of Nuclear Medicine
Volume36
Issue number2
Publication statusPublished - 1995

Fingerprint

Technetium Tc 99m Dimercaptosuccinic Acid
Single-Photon Emission-Computed Tomography
Lung Neoplasms
Squamous Cell Carcinoma
Large Cell Carcinoma
Small Cell Carcinoma
Carcinoid Tumor
Intravenous Injections
Adenocarcinoma
Carcinoma
Lung

ASJC Scopus subject areas

  • Radiological and Ultrasound Technology

Cite this

Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA. / Hirano, T.; Otake, H.; Yoshida, I.; Endo, K.; Lamki, L. M.

In: Journal of Nuclear Medicine, Vol. 36, No. 2, 1995, p. 202-210.

Research output: Contribution to journalArticle

Hirano, T, Otake, H, Yoshida, I, Endo, K & Lamki, LM 1995, 'Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA', Journal of Nuclear Medicine, vol. 36, no. 2, pp. 202-210.
Hirano, T. ; Otake, H. ; Yoshida, I. ; Endo, K. ; Lamki, L. M. / Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA. In: Journal of Nuclear Medicine. 1995 ; Vol. 36, No. 2. pp. 202-210.
@article{46232368f8dc478ab910b6043db814b1,
title = "Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA",
abstract = "To assess the clinical role of 99mTc(V)-DMSA in primary lung cancers, SPECT imaging was performed on 31 patients with suspected lung cancer. Methods: Planar and SPECT images were obtained at 3 to 4 hr after intravenous injection of approximately 555 MBq 99mTc(V)-DMSA. Two uptake ratios (the maximum counts/pixel in the lesion to the average counts in normal tissue) were calculated. Results: Various types of primary lung cancers (adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell carcinoma and bronchial carcinoid tumor) were imaged by 99mTc(V)-DMSA SPECT. Approximately 90{\%} of the lung carcinomas showed increased uptake and were clearly demonstrated by SPECT images. Four cases incidentally revealed osseous metastatic lesion. Three benign lesions did not show increased uptake. Three cases were false-negative and there were no false-positive cases for the primary lesions. Conclusion: Technetium-99m(V)-DMSA SPECT images demonstrated approximately 90{\%} of the primary lung cancers. Uptake ratios were higher in squamous-cell carcinomas than adenocarcinomas. Evaluation of mediastinal tumor extension and nodal metastatic lesion was very difficult by high blood-pool activity in the major cardiovascular structures due to slow blood-pool clearance. However, 99mTc(V)-DMSA SPECT imaging was very useful for detecting primary lung cancers and metastatic lesions to the osseous structures.",
author = "T. Hirano and H. Otake and I. Yoshida and K. Endo and Lamki, {L. M.}",
year = "1995",
language = "English",
volume = "36",
pages = "202--210",
journal = "Journal of Nuclear Medicine",
issn = "0161-5505",
publisher = "Society of Nuclear Medicine Inc.",
number = "2",

}

TY - JOUR

T1 - Primary lung cancer SPECT imaging with pentavalent technetium-99m-DMSA

AU - Hirano, T.

AU - Otake, H.

AU - Yoshida, I.

AU - Endo, K.

AU - Lamki, L. M.

PY - 1995

Y1 - 1995

N2 - To assess the clinical role of 99mTc(V)-DMSA in primary lung cancers, SPECT imaging was performed on 31 patients with suspected lung cancer. Methods: Planar and SPECT images were obtained at 3 to 4 hr after intravenous injection of approximately 555 MBq 99mTc(V)-DMSA. Two uptake ratios (the maximum counts/pixel in the lesion to the average counts in normal tissue) were calculated. Results: Various types of primary lung cancers (adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell carcinoma and bronchial carcinoid tumor) were imaged by 99mTc(V)-DMSA SPECT. Approximately 90% of the lung carcinomas showed increased uptake and were clearly demonstrated by SPECT images. Four cases incidentally revealed osseous metastatic lesion. Three benign lesions did not show increased uptake. Three cases were false-negative and there were no false-positive cases for the primary lesions. Conclusion: Technetium-99m(V)-DMSA SPECT images demonstrated approximately 90% of the primary lung cancers. Uptake ratios were higher in squamous-cell carcinomas than adenocarcinomas. Evaluation of mediastinal tumor extension and nodal metastatic lesion was very difficult by high blood-pool activity in the major cardiovascular structures due to slow blood-pool clearance. However, 99mTc(V)-DMSA SPECT imaging was very useful for detecting primary lung cancers and metastatic lesions to the osseous structures.

AB - To assess the clinical role of 99mTc(V)-DMSA in primary lung cancers, SPECT imaging was performed on 31 patients with suspected lung cancer. Methods: Planar and SPECT images were obtained at 3 to 4 hr after intravenous injection of approximately 555 MBq 99mTc(V)-DMSA. Two uptake ratios (the maximum counts/pixel in the lesion to the average counts in normal tissue) were calculated. Results: Various types of primary lung cancers (adenocarcinoma, squamous-cell carcinoma, small-cell carcinoma, large-cell carcinoma and bronchial carcinoid tumor) were imaged by 99mTc(V)-DMSA SPECT. Approximately 90% of the lung carcinomas showed increased uptake and were clearly demonstrated by SPECT images. Four cases incidentally revealed osseous metastatic lesion. Three benign lesions did not show increased uptake. Three cases were false-negative and there were no false-positive cases for the primary lesions. Conclusion: Technetium-99m(V)-DMSA SPECT images demonstrated approximately 90% of the primary lung cancers. Uptake ratios were higher in squamous-cell carcinomas than adenocarcinomas. Evaluation of mediastinal tumor extension and nodal metastatic lesion was very difficult by high blood-pool activity in the major cardiovascular structures due to slow blood-pool clearance. However, 99mTc(V)-DMSA SPECT imaging was very useful for detecting primary lung cancers and metastatic lesions to the osseous structures.

UR - http://www.scopus.com/inward/record.url?scp=0028869821&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0028869821&partnerID=8YFLogxK

M3 - Article

C2 - 7830114

AN - SCOPUS:0028869821

VL - 36

SP - 202

EP - 210

JO - Journal of Nuclear Medicine

JF - Journal of Nuclear Medicine

SN - 0161-5505

IS - 2

ER -