Prevalence of celiac disease in Omani children with type 1 diabetes mellitus: A cross sectional study

Siham Al-Sinani, Sharef Waadallah Sharef, Saif Al-Yaarubi, Ibrahim Al-Zakwani, Khalid Al-Naamani, Aisha Al-Hajri, Said Al-Hasani

Research output: Contribution to journalArticle

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Abstract

Objective: Published studies on the prevalence of celiac disease in type 1 diabetes mellitus from the Arab World are scant. We aim to report the prevalence of celiac disease in Omani children with type 1 diabetes mellitus. Methods: Children with type 1 diabetes mellitus were prospectively screened for celiac disease, at Sultan Qaboos University Hospital, Muscat, Oman over a period of one year (June 2011 - May 2012). Serum anti tissue transglutaminase IgA, endomysial IgA antibodies and total IgA were measured for screening of celiac disease. Children with positive anti-tissue transglutaminase and/or endomysial IgA antibodies underwent endoscopy. Results: A total of 103 children with type 1 diabetes mellitus were initially included. Ten patients were lost to follow up. Ninety-three patients aged 2-17 years underwent screening for celiac disease. Sixteen patients had positive anti-tissue transglutaminase (17%). Fourteen patients underwent endoscopy with duodenal biopsies, while two were lost to follow-up. Five patients with positive antitissue transglutaminase had intestinal biopsy proven celiac disease. The prevalence of celiac disease is 5.5% in our cohort of children and adolescents with type 1 diabetes mellitus. Conclusions: The prevalence of celiac disease in Omani children and adolescents with type 1 diabetes mellitus is similar to the World's reported prevalence, but is less than that reported for Middle Eastern Arab children. To our knowledge, this is the first reported study on the prevalence of celiac disease in Omani children with type 1 diabetes mellitus.

Original languageEnglish
Pages (from-to)260-263
Number of pages4
JournalOman Medical Journal
Volume28
Issue number4
DOIs
Publication statusPublished - 2013

Fingerprint

Celiac Disease
Type 1 Diabetes Mellitus
Cross-Sectional Studies
Immunoglobulin A
Lost to Follow-Up
Endoscopy
Arab World
Oman
Biopsy
Transglutaminases
Antibodies
Serum

Keywords

  • Anti-tissue transglutaminase
  • Celiac Disease
  • Oman
  • Type 1 Diabetes Mellitus

ASJC Scopus subject areas

  • Medicine(all)

Cite this

Prevalence of celiac disease in Omani children with type 1 diabetes mellitus : A cross sectional study. / Al-Sinani, Siham; Waadallah Sharef, Sharef; Al-Yaarubi, Saif; Al-Zakwani, Ibrahim; Al-Naamani, Khalid; Al-Hajri, Aisha; Al-Hasani, Said.

In: Oman Medical Journal, Vol. 28, No. 4, 2013, p. 260-263.

Research output: Contribution to journalArticle

Al-Sinani, Siham ; Waadallah Sharef, Sharef ; Al-Yaarubi, Saif ; Al-Zakwani, Ibrahim ; Al-Naamani, Khalid ; Al-Hajri, Aisha ; Al-Hasani, Said. / Prevalence of celiac disease in Omani children with type 1 diabetes mellitus : A cross sectional study. In: Oman Medical Journal. 2013 ; Vol. 28, No. 4. pp. 260-263.
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