Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function

Marina Urena, John G. Webb, Corrado Tamburino, Antonio J. Muñoz-García, Asim Cheema, Antonio E. Dager, Vicenç Serra, Ignacio J. Amat-Santos, Marco Barbanti, Sebastiano Immè, Juan H Alonso Briales, Luis Miguel Benitez, Hatim Al Lawati, Angela Maria Cucalon, Bruno García Del Blanco, Javier López, Eric Dumont, Robert DeLarochellière, Henrique B. Ribeiro, Luis Nombela-Franco & 2 others François Philippon, Josep Rodés-Cabau

Research output: Contribution to journalArticle

141 Citations (Scopus)

Abstract

Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients. Methods and Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included. Of them, 239 patients (15.4%) required a PPI within the first 30 days after transcatheter aortic valve implantation. At a mean follow-up of 22±17 months, no association was observed between the need for 30-day PPI and all-cause mortality (hazard ratio, 0.98; 95% confidence interval, 0.74-1.30; P=0.871), cardiovascular mortality (hazard ratio, 0.81; 95% confidence interval, 0.56-1.17; P=0.270), and all-cause mortality or rehospitalization for heart failure (hazard ratio, 1.00; 95% confidence interval, 0.77-1.30; P=0.980). A lower rate of unexpected (sudden or unknown) death was observed in patients with PPI (hazard ratio, 0.31; 95% confidence interval, 0.11-0.85; P=0.023). Patients with new PPI showed a poorer evolution of left ventricular ejection fraction over time (P=0.017), and new PPI was an independent predictor of left ventricular ejection fraction decrease at the 6-to 12-month follow-up (estimated coefficient, -2.26; 95% confidence interval, -4.07 to -0.44; P=0.013; R 2=0.121). Conclusions: The need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death. However, new PPI did have a negative effect on left ventricular function over time.

Original languageEnglish
Pages (from-to)1233-1243
Number of pages11
JournalCirculation
Volume129
Issue number11
DOIs
Publication statusPublished - 2014

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Left Ventricular Function
Confidence Intervals
Stroke Volume
Mortality
Heart Failure
Transcatheter Aortic Valve Replacement

Keywords

  • Aortic stenosis
  • Aortic valve
  • Artificial
  • Cardiac
  • Death
  • Heart valves
  • Pacemaker
  • Sudden

ASJC Scopus subject areas

  • Physiology (medical)
  • Cardiology and Cardiovascular Medicine

Cite this

Urena, M., Webb, J. G., Tamburino, C., Muñoz-García, A. J., Cheema, A., Dager, A. E., ... Rodés-Cabau, J. (2014). Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function. Circulation, 129(11), 1233-1243. https://doi.org/10.1161/CIRCULATIONAHA.113.005479

Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function. / Urena, Marina; Webb, John G.; Tamburino, Corrado; Muñoz-García, Antonio J.; Cheema, Asim; Dager, Antonio E.; Serra, Vicenç; Amat-Santos, Ignacio J.; Barbanti, Marco; Immè, Sebastiano; Briales, Juan H Alonso; Benitez, Luis Miguel; Al Lawati, Hatim; Cucalon, Angela Maria; Del Blanco, Bruno García; López, Javier; Dumont, Eric; DeLarochellière, Robert; Ribeiro, Henrique B.; Nombela-Franco, Luis; Philippon, François; Rodés-Cabau, Josep.

In: Circulation, Vol. 129, No. 11, 2014, p. 1233-1243.

Research output: Contribution to journalArticle

Urena, M, Webb, JG, Tamburino, C, Muñoz-García, AJ, Cheema, A, Dager, AE, Serra, V, Amat-Santos, IJ, Barbanti, M, Immè, S, Briales, JHA, Benitez, LM, Al Lawati, H, Cucalon, AM, Del Blanco, BG, López, J, Dumont, E, DeLarochellière, R, Ribeiro, HB, Nombela-Franco, L, Philippon, F & Rodés-Cabau, J 2014, 'Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function', Circulation, vol. 129, no. 11, pp. 1233-1243. https://doi.org/10.1161/CIRCULATIONAHA.113.005479
Urena, Marina ; Webb, John G. ; Tamburino, Corrado ; Muñoz-García, Antonio J. ; Cheema, Asim ; Dager, Antonio E. ; Serra, Vicenç ; Amat-Santos, Ignacio J. ; Barbanti, Marco ; Immè, Sebastiano ; Briales, Juan H Alonso ; Benitez, Luis Miguel ; Al Lawati, Hatim ; Cucalon, Angela Maria ; Del Blanco, Bruno García ; López, Javier ; Dumont, Eric ; DeLarochellière, Robert ; Ribeiro, Henrique B. ; Nombela-Franco, Luis ; Philippon, François ; Rodés-Cabau, Josep. / Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function. In: Circulation. 2014 ; Vol. 129, No. 11. pp. 1233-1243.
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abstract = "Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients. Methods and Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included. Of them, 239 patients (15.4{\%}) required a PPI within the first 30 days after transcatheter aortic valve implantation. At a mean follow-up of 22±17 months, no association was observed between the need for 30-day PPI and all-cause mortality (hazard ratio, 0.98; 95{\%} confidence interval, 0.74-1.30; P=0.871), cardiovascular mortality (hazard ratio, 0.81; 95{\%} confidence interval, 0.56-1.17; P=0.270), and all-cause mortality or rehospitalization for heart failure (hazard ratio, 1.00; 95{\%} confidence interval, 0.77-1.30; P=0.980). A lower rate of unexpected (sudden or unknown) death was observed in patients with PPI (hazard ratio, 0.31; 95{\%} confidence interval, 0.11-0.85; P=0.023). Patients with new PPI showed a poorer evolution of left ventricular ejection fraction over time (P=0.017), and new PPI was an independent predictor of left ventricular ejection fraction decrease at the 6-to 12-month follow-up (estimated coefficient, -2.26; 95{\%} confidence interval, -4.07 to -0.44; P=0.013; R 2=0.121). Conclusions: The need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death. However, new PPI did have a negative effect on left ventricular function over time.",
keywords = "Aortic stenosis, Aortic valve, Artificial, Cardiac, Death, Heart valves, Pacemaker, Sudden",
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T1 - Permanent pacemaker implantation after transcatheter aortic valve implantation impact on late clinical outcomes and left ventricular function

AU - Urena, Marina

AU - Webb, John G.

AU - Tamburino, Corrado

AU - Muñoz-García, Antonio J.

AU - Cheema, Asim

AU - Dager, Antonio E.

AU - Serra, Vicenç

AU - Amat-Santos, Ignacio J.

AU - Barbanti, Marco

AU - Immè, Sebastiano

AU - Briales, Juan H Alonso

AU - Benitez, Luis Miguel

AU - Al Lawati, Hatim

AU - Cucalon, Angela Maria

AU - Del Blanco, Bruno García

AU - López, Javier

AU - Dumont, Eric

AU - DeLarochellière, Robert

AU - Ribeiro, Henrique B.

AU - Nombela-Franco, Luis

AU - Philippon, François

AU - Rodés-Cabau, Josep

PY - 2014

Y1 - 2014

N2 - Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients. Methods and Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included. Of them, 239 patients (15.4%) required a PPI within the first 30 days after transcatheter aortic valve implantation. At a mean follow-up of 22±17 months, no association was observed between the need for 30-day PPI and all-cause mortality (hazard ratio, 0.98; 95% confidence interval, 0.74-1.30; P=0.871), cardiovascular mortality (hazard ratio, 0.81; 95% confidence interval, 0.56-1.17; P=0.270), and all-cause mortality or rehospitalization for heart failure (hazard ratio, 1.00; 95% confidence interval, 0.77-1.30; P=0.980). A lower rate of unexpected (sudden or unknown) death was observed in patients with PPI (hazard ratio, 0.31; 95% confidence interval, 0.11-0.85; P=0.023). Patients with new PPI showed a poorer evolution of left ventricular ejection fraction over time (P=0.017), and new PPI was an independent predictor of left ventricular ejection fraction decrease at the 6-to 12-month follow-up (estimated coefficient, -2.26; 95% confidence interval, -4.07 to -0.44; P=0.013; R 2=0.121). Conclusions: The need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death. However, new PPI did have a negative effect on left ventricular function over time.

AB - Background: Very few data exist on the clinical impact of permanent pacemaker implantation (PPI) after transcatheter aortic valve implantation. The objective of this study was to assess the impact of PPI after transcatheter aortic valve implantation on late outcomes in a large cohort of patients. Methods and Results: A total of 1556 consecutive patients without prior PPI undergoing transcatheter aortic valve implantation were included. Of them, 239 patients (15.4%) required a PPI within the first 30 days after transcatheter aortic valve implantation. At a mean follow-up of 22±17 months, no association was observed between the need for 30-day PPI and all-cause mortality (hazard ratio, 0.98; 95% confidence interval, 0.74-1.30; P=0.871), cardiovascular mortality (hazard ratio, 0.81; 95% confidence interval, 0.56-1.17; P=0.270), and all-cause mortality or rehospitalization for heart failure (hazard ratio, 1.00; 95% confidence interval, 0.77-1.30; P=0.980). A lower rate of unexpected (sudden or unknown) death was observed in patients with PPI (hazard ratio, 0.31; 95% confidence interval, 0.11-0.85; P=0.023). Patients with new PPI showed a poorer evolution of left ventricular ejection fraction over time (P=0.017), and new PPI was an independent predictor of left ventricular ejection fraction decrease at the 6-to 12-month follow-up (estimated coefficient, -2.26; 95% confidence interval, -4.07 to -0.44; P=0.013; R 2=0.121). Conclusions: The need for PPI was a frequent complication of transcatheter aortic valve implantation, but it was not associated with any increase in overall or cardiovascular death or rehospitalization for heart failure after a mean follow-up of ≈2 years. Indeed, 30-day PPI was a protective factor for the occurrence of unexpected (sudden or unknown) death. However, new PPI did have a negative effect on left ventricular function over time.

KW - Aortic stenosis

KW - Aortic valve

KW - Artificial

KW - Cardiac

KW - Death

KW - Heart valves

KW - Pacemaker

KW - Sudden

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U2 - 10.1161/CIRCULATIONAHA.113.005479

DO - 10.1161/CIRCULATIONAHA.113.005479

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