Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions

Sarfaraz Kamangar, Irfan Anjum Badruddin, Kalimuthu Govindaraju, N. Nik-Ghazali, A. Badarudin, Girish N. Viswanathan, N. J.Salman Ahmed, T. M.Yunus Khan

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The purpose of this study is to investigate the effect of various degrees of percentage stenosis on hemodynamic parameters during the hyperemic flow condition. 3D patient-specific coronary artery models were generated based on the CT scan data using MIMICS-18. Numerical simulation was performed for normal and stenosed coronary artery models of 70, 80 and 90% AS (area stenosis). Pressure, velocity, wall shear stress and fractional flow reserve (FFR) were measured and compared with the normal coronary artery model during the cardiac cycle. The results show that, as the percentage AS increase, the pressure drop increases as compared with the normal coronary artery model. Considerable elevation of velocity was observed as the percentage AS increases. The results also demonstrate a recirculation zone immediate after the stenosis which could lead to further progression of stenosis in the flow-disturbed area. Highest wall shear stress was observed for 90% AS as compared to other models that could result in the rupture of coronary artery. The FFR of 90% AS is found to be considerably low.

Original languageEnglish
Pages (from-to)1451-1461
Number of pages11
JournalMedical and Biological Engineering and Computing
Volume55
Issue number8
DOIs
Publication statusPublished - Aug 1 2017

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Hemodynamics
Shear stress
Computerized tomography
Pressure drop
Computer simulation

Keywords

  • Coronary artery
  • FFR
  • Non-Newtonian flow
  • Stenosis

ASJC Scopus subject areas

  • Biomedical Engineering
  • Computer Science Applications

Cite this

Kamangar, S., Badruddin, I. A., Govindaraju, K., Nik-Ghazali, N., Badarudin, A., Viswanathan, G. N., ... Khan, T. M. Y. (2017). Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions. Medical and Biological Engineering and Computing, 55(8), 1451-1461. https://doi.org/10.1007/s11517-016-1604-8

Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions. / Kamangar, Sarfaraz; Badruddin, Irfan Anjum; Govindaraju, Kalimuthu; Nik-Ghazali, N.; Badarudin, A.; Viswanathan, Girish N.; Ahmed, N. J.Salman; Khan, T. M.Yunus.

In: Medical and Biological Engineering and Computing, Vol. 55, No. 8, 01.08.2017, p. 1451-1461.

Research output: Contribution to journalArticle

Kamangar, S, Badruddin, IA, Govindaraju, K, Nik-Ghazali, N, Badarudin, A, Viswanathan, GN, Ahmed, NJS & Khan, TMY 2017, 'Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions', Medical and Biological Engineering and Computing, vol. 55, no. 8, pp. 1451-1461. https://doi.org/10.1007/s11517-016-1604-8
Kamangar S, Badruddin IA, Govindaraju K, Nik-Ghazali N, Badarudin A, Viswanathan GN et al. Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions. Medical and Biological Engineering and Computing. 2017 Aug 1;55(8):1451-1461. https://doi.org/10.1007/s11517-016-1604-8
Kamangar, Sarfaraz ; Badruddin, Irfan Anjum ; Govindaraju, Kalimuthu ; Nik-Ghazali, N. ; Badarudin, A. ; Viswanathan, Girish N. ; Ahmed, N. J.Salman ; Khan, T. M.Yunus. / Patient-specific 3D hemodynamics modelling of left coronary artery under hyperemic conditions. In: Medical and Biological Engineering and Computing. 2017 ; Vol. 55, No. 8. pp. 1451-1461.
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