Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery

Sarfaraz Kamangar, Irfan Anjum Badruddin, N. Ameer Ahamad, Manzoor Elahi M. Soudagar, Kalimuthu Govindaraju, N. Nik-Ghazali, N. J. Salman Ahmed, T. M. Yunus Khan

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

The current study investigates the effect of multi stenosis on the hemodynamic parameters such as wall pressure, velocity and wall shear stress in the realistic left coronary artery. Patients CT scan image data of normal and diseased left coronary artery was chosen for the reconstruction of 3D coronary artery models. The diseased 3D model of left coronary artery shows a narrowing of more than 70% and 80% of area stenosis (AS) at the left main stem (LMS) and left circumflex (LCX) respectively. The results show that the decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. The maximum pressure drop was noted across the 80%Â AS at the left circumflex branch. The recirculation zone was also observed immediate to the stenosis and highest wall shear stress was found across the 80% area stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding on the hemodynamics in realistic coronary artery.

Original languageEnglish
Pages (from-to)257-266
Number of pages10
JournalBio-Medical Materials and Engineering
Volume28
Issue number3
DOIs
Publication statusPublished - 2017

Fingerprint

Shear stress
Blood
Hemodynamics
Pressure drop
Computerized tomography

Keywords

  • CFD
  • computer tomography
  • Coronary artery
  • non-Newtonian flow
  • stenosis

ASJC Scopus subject areas

  • Biomaterials
  • Biomedical Engineering

Cite this

Kamangar, S., Badruddin, I. A., Ameer Ahamad, N., Soudagar, M. E. M., Govindaraju, K., Nik-Ghazali, N., ... Yunus Khan, T. M. (2017). Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery. Bio-Medical Materials and Engineering, 28(3), 257-266. https://doi.org/10.3233/BME-171672

Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery. / Kamangar, Sarfaraz; Badruddin, Irfan Anjum; Ameer Ahamad, N.; Soudagar, Manzoor Elahi M.; Govindaraju, Kalimuthu; Nik-Ghazali, N.; Salman Ahmed, N. J.; Yunus Khan, T. M.

In: Bio-Medical Materials and Engineering, Vol. 28, No. 3, 2017, p. 257-266.

Research output: Contribution to journalArticle

Kamangar, S, Badruddin, IA, Ameer Ahamad, N, Soudagar, MEM, Govindaraju, K, Nik-Ghazali, N, Salman Ahmed, NJ & Yunus Khan, TM 2017, 'Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery', Bio-Medical Materials and Engineering, vol. 28, no. 3, pp. 257-266. https://doi.org/10.3233/BME-171672
Kamangar S, Badruddin IA, Ameer Ahamad N, Soudagar MEM, Govindaraju K, Nik-Ghazali N et al. Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery. Bio-Medical Materials and Engineering. 2017;28(3):257-266. https://doi.org/10.3233/BME-171672
Kamangar, Sarfaraz ; Badruddin, Irfan Anjum ; Ameer Ahamad, N. ; Soudagar, Manzoor Elahi M. ; Govindaraju, Kalimuthu ; Nik-Ghazali, N. ; Salman Ahmed, N. J. ; Yunus Khan, T. M. / Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery. In: Bio-Medical Materials and Engineering. 2017 ; Vol. 28, No. 3. pp. 257-266.
@article{247e3fdce4fe472d89bc8a5659894485,
title = "Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery",
abstract = "The current study investigates the effect of multi stenosis on the hemodynamic parameters such as wall pressure, velocity and wall shear stress in the realistic left coronary artery. Patients CT scan image data of normal and diseased left coronary artery was chosen for the reconstruction of 3D coronary artery models. The diseased 3D model of left coronary artery shows a narrowing of more than 70{\%} and 80{\%} of area stenosis (AS) at the left main stem (LMS) and left circumflex (LCX) respectively. The results show that the decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. The maximum pressure drop was noted across the 80{\%}{\^A} AS at the left circumflex branch. The recirculation zone was also observed immediate to the stenosis and highest wall shear stress was found across the 80{\%} area stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding on the hemodynamics in realistic coronary artery.",
keywords = "CFD, computer tomography, Coronary artery, non-Newtonian flow, stenosis",
author = "Sarfaraz Kamangar and Badruddin, {Irfan Anjum} and {Ameer Ahamad}, N. and Soudagar, {Manzoor Elahi M.} and Kalimuthu Govindaraju and N. Nik-Ghazali and {Salman Ahmed}, {N. J.} and {Yunus Khan}, {T. M.}",
year = "2017",
doi = "10.3233/BME-171672",
language = "English",
volume = "28",
pages = "257--266",
journal = "Bio-Medical Materials and Engineering",
issn = "0959-2989",
publisher = "IOS Press",
number = "3",

}

TY - JOUR

T1 - Patient specific 3-d modeling of blood flow in a multi-stenosed left coronary artery

AU - Kamangar, Sarfaraz

AU - Badruddin, Irfan Anjum

AU - Ameer Ahamad, N.

AU - Soudagar, Manzoor Elahi M.

AU - Govindaraju, Kalimuthu

AU - Nik-Ghazali, N.

AU - Salman Ahmed, N. J.

AU - Yunus Khan, T. M.

PY - 2017

Y1 - 2017

N2 - The current study investigates the effect of multi stenosis on the hemodynamic parameters such as wall pressure, velocity and wall shear stress in the realistic left coronary artery. Patients CT scan image data of normal and diseased left coronary artery was chosen for the reconstruction of 3D coronary artery models. The diseased 3D model of left coronary artery shows a narrowing of more than 70% and 80% of area stenosis (AS) at the left main stem (LMS) and left circumflex (LCX) respectively. The results show that the decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. The maximum pressure drop was noted across the 80%Â AS at the left circumflex branch. The recirculation zone was also observed immediate to the stenosis and highest wall shear stress was found across the 80% area stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding on the hemodynamics in realistic coronary artery.

AB - The current study investigates the effect of multi stenosis on the hemodynamic parameters such as wall pressure, velocity and wall shear stress in the realistic left coronary artery. Patients CT scan image data of normal and diseased left coronary artery was chosen for the reconstruction of 3D coronary artery models. The diseased 3D model of left coronary artery shows a narrowing of more than 70% and 80% of area stenosis (AS) at the left main stem (LMS) and left circumflex (LCX) respectively. The results show that the decrease in pressure was found downstream to the stenosis as compared to the coronary artery without stenosis. The maximum pressure drop was noted across the 80%Â AS at the left circumflex branch. The recirculation zone was also observed immediate to the stenosis and highest wall shear stress was found across the 80% area stenosis. Our analysis provides an insight into the distribution of wall shear stress and pressure drop, thus improving our understanding on the hemodynamics in realistic coronary artery.

KW - CFD

KW - computer tomography

KW - Coronary artery

KW - non-Newtonian flow

KW - stenosis

UR - http://www.scopus.com/inward/record.url?scp=85019912059&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85019912059&partnerID=8YFLogxK

U2 - 10.3233/BME-171672

DO - 10.3233/BME-171672

M3 - Article

VL - 28

SP - 257

EP - 266

JO - Bio-Medical Materials and Engineering

JF - Bio-Medical Materials and Engineering

SN - 0959-2989

IS - 3

ER -