TY - JOUR
T1 - Parallel microdevice for high throughput analysis of levofloxacin using tris (2,2'-bipyridyl) ruthenium (II) and peroxydisulfate chemiluminescence system
AU - Al Lawati, Haider A.J.
AU - Al Gharibi, Eiman
AU - Al Kindy, Salma M.Z.
AU - Suliman, Fakhr Eldin O.
AU - Al-Lawati, Ali M.
PY - 2014
Y1 - 2014
N2 - A parallel microdevice has been developed for high throughput analysis using microfluidics. The detection method is based on a chemiluminescence (CL) system based on the oxidation of tris (2,2'-bipyridyl) Ru(II) [Ru (bipy) 32+] by peroxydisulfate. The device consists of a photoreactor chip and two detection chips. The sample throughput can reach up to 720 runs/h with the total reagent consumption of only 2.4 mL. The parallel microdevice was evaluated using levofloxacin (LEVO) in pharmaceutical preparations. The various factors that affect the CL signal were optimized, and the LOD was found to be 30 and 27 μg/L for the two detectors, respectively (S/N = 3), while RSD was 1.1% (n = 15) for 1.0 mg/L LEVO. Two tablet samples that contain LEVO as an active ingredient were successfully analyzed using the proposed parallel microdevice.
AB - A parallel microdevice has been developed for high throughput analysis using microfluidics. The detection method is based on a chemiluminescence (CL) system based on the oxidation of tris (2,2'-bipyridyl) Ru(II) [Ru (bipy) 32+] by peroxydisulfate. The device consists of a photoreactor chip and two detection chips. The sample throughput can reach up to 720 runs/h with the total reagent consumption of only 2.4 mL. The parallel microdevice was evaluated using levofloxacin (LEVO) in pharmaceutical preparations. The various factors that affect the CL signal were optimized, and the LOD was found to be 30 and 27 μg/L for the two detectors, respectively (S/N = 3), while RSD was 1.1% (n = 15) for 1.0 mg/L LEVO. Two tablet samples that contain LEVO as an active ingredient were successfully analyzed using the proposed parallel microdevice.
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U2 - 10.5740/jaoacint.12-025
DO - 10.5740/jaoacint.12-025
M3 - Article
C2 - 25145137
AN - SCOPUS:84905389393
SN - 1060-3271
VL - 97
SP - 1056
EP - 1060
JO - Journal of AOAC International
JF - Journal of AOAC International
IS - 4
ER -