Papaya epicarp extract protects against aluminum-induced neurotoxicity

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Abstract

In a previous study, we demonstrated the ability of papaya epicarp extract (PEE) to protect against oxidative stress-induced insult in human SH-SY5Y neuronal cells in a mechanism that appeared to be by means of PEE potent antioxidant properties. To further understand this relationship, we examined the effect of PEE intervention on aluminum (Al)-induced cytotoxicity in SH-SY5Y cells. The results indicated that PEE was effective in protecting against Al-induced cell death in a dose-dependent manner. PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). PEE ameliorated the Al-induced impairment of intracellular glutathione and total antioxidant capacity. Together, these findings indicate that PEE supplementation can play a neuroprotective role in ameliorating the changes in redox status of SH-SY5Y cells exposed to Al, a wellknown environmental toxin that is involved in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders.

Original languageEnglish
Pages (from-to)1018-1022
Number of pages5
JournalExperimental Biology and Medicine
Volume237
Issue number9
DOIs
Publication statusPublished - Sep 1 2012

Fingerprint

Carica
Aluminum
Antioxidants
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Neurodegenerative diseases
Neurodegenerative Diseases
Oxidative stress
Cell death
Cytotoxicity
Glutathione Peroxidase
Folic Acid
Catalase
Superoxide Dismutase
Glutathione
Aptitude
Oxidation-Reduction
Oxidative Stress
Cell Death
Enzymes

Keywords

  • Aluminum
  • Neuroprotection
  • Oxidative stress
  • Papaya epicarp extract
  • SH-SY5Y cell

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

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title = "Papaya epicarp extract protects against aluminum-induced neurotoxicity",
abstract = "In a previous study, we demonstrated the ability of papaya epicarp extract (PEE) to protect against oxidative stress-induced insult in human SH-SY5Y neuronal cells in a mechanism that appeared to be by means of PEE potent antioxidant properties. To further understand this relationship, we examined the effect of PEE intervention on aluminum (Al)-induced cytotoxicity in SH-SY5Y cells. The results indicated that PEE was effective in protecting against Al-induced cell death in a dose-dependent manner. PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). PEE ameliorated the Al-induced impairment of intracellular glutathione and total antioxidant capacity. Together, these findings indicate that PEE supplementation can play a neuroprotective role in ameliorating the changes in redox status of SH-SY5Y cells exposed to Al, a wellknown environmental toxin that is involved in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders.",
keywords = "Aluminum, Neuroprotection, Oxidative stress, Papaya epicarp extract, SH-SY5Y cell",
author = "Waly, {Mostafa I.} and Nejib Guizani and Amanat Ali and Rahman, {Mohammad Shafiur}",
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AU - Waly, Mostafa I.

AU - Guizani, Nejib

AU - Ali, Amanat

AU - Rahman, Mohammad Shafiur

PY - 2012/9/1

Y1 - 2012/9/1

N2 - In a previous study, we demonstrated the ability of papaya epicarp extract (PEE) to protect against oxidative stress-induced insult in human SH-SY5Y neuronal cells in a mechanism that appeared to be by means of PEE potent antioxidant properties. To further understand this relationship, we examined the effect of PEE intervention on aluminum (Al)-induced cytotoxicity in SH-SY5Y cells. The results indicated that PEE was effective in protecting against Al-induced cell death in a dose-dependent manner. PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). PEE ameliorated the Al-induced impairment of intracellular glutathione and total antioxidant capacity. Together, these findings indicate that PEE supplementation can play a neuroprotective role in ameliorating the changes in redox status of SH-SY5Y cells exposed to Al, a wellknown environmental toxin that is involved in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders.

AB - In a previous study, we demonstrated the ability of papaya epicarp extract (PEE) to protect against oxidative stress-induced insult in human SH-SY5Y neuronal cells in a mechanism that appeared to be by means of PEE potent antioxidant properties. To further understand this relationship, we examined the effect of PEE intervention on aluminum (Al)-induced cytotoxicity in SH-SY5Y cells. The results indicated that PEE was effective in protecting against Al-induced cell death in a dose-dependent manner. PEE restored the Al-induced inhibition of folate-dependent methionine synthase activity and the antioxidant enzymes (catalase, glutathione peroxidases and superoxide dismutase). PEE ameliorated the Al-induced impairment of intracellular glutathione and total antioxidant capacity. Together, these findings indicate that PEE supplementation can play a neuroprotective role in ameliorating the changes in redox status of SH-SY5Y cells exposed to Al, a wellknown environmental toxin that is involved in the pathogenesis of neurodegenerative diseases and neurodevelopmental disorders.

KW - Aluminum

KW - Neuroprotection

KW - Oxidative stress

KW - Papaya epicarp extract

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