Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation

Richard Deth, Christina Muratore, Mostafa Waly

Research output: Chapter in Book/Report/Conference proceedingChapter

Abstract

Neurons operate under unique redox conditions, increasing their vulnerability to oxidative stress, and recent studies provide evidence of oxidative stress and neuroinflammation in autism. Impaired methylation is a consequence of oxidative stress, mediated in major part by inhibition of the folate- and colbalamin-dependent enzyme methionine synthase. Since methionine synthase activity is essential for dopamine-stimulated phospholipid methylation, some symptoms of autism may reflect impairment of this process. For example, dopamine D4 receptor activation plays an important role in gamma frequency synchronization of neural networks during attention, and autistic children display deficits in synchronization. This chapter reviews the metabolic events contributing to impaired methylation and examines the mechanisms by which they may contribute to neurodevelopmental disorders such as autism.

Original languageEnglish
Title of host publicationThe Neurochemical Basis of Autism: From Molecules to Minicolumns
PublisherSpringer US
Pages185-199
Number of pages15
ISBN (Print)9781441912725, 9781441912718
DOIs
Publication statusPublished - 2010

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Autistic Disorder
5-Methyltetrahydrofolate-Homocysteine S-Methyltransferase
Methylation
Dopamine
Phospholipids
Oxidative Stress
Dopamine D4 Receptors
Folic Acid
Oxidation-Reduction
Neurons
Enzymes

ASJC Scopus subject areas

  • Medicine(all)
  • Neuroscience(all)

Cite this

Deth, R., Muratore, C., & Waly, M. (2010). Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation. In The Neurochemical Basis of Autism: From Molecules to Minicolumns (pp. 185-199). Springer US. https://doi.org/10.1007/978-1-4419-1272-5_12

Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation. / Deth, Richard; Muratore, Christina; Waly, Mostafa.

The Neurochemical Basis of Autism: From Molecules to Minicolumns. Springer US, 2010. p. 185-199.

Research output: Chapter in Book/Report/Conference proceedingChapter

Deth, R, Muratore, C & Waly, M 2010, Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation. in The Neurochemical Basis of Autism: From Molecules to Minicolumns. Springer US, pp. 185-199. https://doi.org/10.1007/978-1-4419-1272-5_12
Deth R, Muratore C, Waly M. Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation. In The Neurochemical Basis of Autism: From Molecules to Minicolumns. Springer US. 2010. p. 185-199 https://doi.org/10.1007/978-1-4419-1272-5_12
Deth, Richard ; Muratore, Christina ; Waly, Mostafa. / Oxidative stress in autism and its implications for dopamine-stimulated phospholipid methylation. The Neurochemical Basis of Autism: From Molecules to Minicolumns. Springer US, 2010. pp. 185-199
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