Numerical investigation of the effect of stenosis geometry on the coronary diagnostic parameters

Sarfaraz Kamangar, Govindaraju Kalimuthu, Irfan Anjum Badruddin, A. Badarudin, N. J. Salman Ahmed, T. M Yunus Khan

Research output: Contribution to journalArticle

13 Citations (Scopus)

Abstract

The present study deals with the functional severity of a coronary artery stenosis assessed by the fractional flow reserve (FFR). The effects of different geometrical shapes of lesion on the diagnostic parameters are unknown. In this study, 3D computational simulation of blood flow in three different geometrical shapes of stenosis (triangular, elliptical, and trapezium) is considered in steady and transient conditions for 70% (moderate), 80% (intermediate), and 90% (severe) area stenosis (AS). For a given percentage AS, the variation of diagnostic parameters which are derived from pressure drop across the stenosis was found in three different geometrical shapes of stenosis and it was observed that FFR is higher in triangular shape and lower in trapezium shape. The pressure drop coefficient (CDP) was higher in trapezium shape and lower in triangular model whereas the LFC shows opposite trend. From the clinical perspective, the relationship between percentage AS and FFR is linear and inversely related in all the three models. A cut-off value of 0.75 for FFR was observed at 76.5% AS in trapezium model, 79.5% in elliptical model, and 82.7% AS for the triangular shaped model. The misinterpretation of the functional severity of the stenosis is in the region of 76.5%-82.7 % AS from different shapes of stenosis models.

Original languageEnglish
Article number354946
JournalScientific World Journal
Volume2014
DOIs
Publication statusPublished - 2014

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Pathologic Constriction
geometry
Geometry
Pressure drop
pressure drop
Cytidine Diphosphate
effect
parameter
lesion
Blood
Pressure
blood
Coronary Stenosis
simulation

ASJC Scopus subject areas

  • Medicine(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Environmental Science(all)

Cite this

Numerical investigation of the effect of stenosis geometry on the coronary diagnostic parameters. / Kamangar, Sarfaraz; Kalimuthu, Govindaraju; Anjum Badruddin, Irfan; Badarudin, A.; Salman Ahmed, N. J.; Khan, T. M Yunus.

In: Scientific World Journal, Vol. 2014, 354946, 2014.

Research output: Contribution to journalArticle

Kamangar, Sarfaraz ; Kalimuthu, Govindaraju ; Anjum Badruddin, Irfan ; Badarudin, A. ; Salman Ahmed, N. J. ; Khan, T. M Yunus. / Numerical investigation of the effect of stenosis geometry on the coronary diagnostic parameters. In: Scientific World Journal. 2014 ; Vol. 2014.
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