A numerical investigation of inclined jet impingement micro-channel heat sink used for electronic cooling applications is presented. This study focuses on analysis of three-dimensional micro-channel heat sink using different types of nanofluids. The study is simulated for 6, 10, 14, 18 jets; these are inclined at 45° and 135° from the upper surface of the fluid. Nanofluids comprised of water and nanoparticles, aluminium oxide (Al2O3) and titanium oxide (TiO2) are used in fractions of 0.1, 0.5 and 1%. The geometry of the micro-jet impingement heat sink was constructed using SOLIDWORKS design software, and the simulation was performed on Ansys Fluent solver. The influence of parameters such as mass flow rate, number of jets and fraction of nanoparticles on heat transfer was determined. Results obtained for different nanofluids were compared with results of base fluid. It showed that nanofluid-containing TiO2 nanoparticles dissipate more heat than Al2O3 nanoparticles. It also revealed that 1.0% solid volume fraction of TiO2 in water gave maximum outlet bulk mean temperature. The results were in good agreement with previously performed numerical investigation.