Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography

Murtadha Al-Khabori, Shahina Daar, Said Al-Busafi, Humoud AL-Dhuhli, Al Ghalya A. Alumairi, Moez Hassan, Sara Al-Rahbi, Umaima Al-Ajmi

Research output: Contribution to journalArticle

2 Citations (Scopus)

Abstract

Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.

Original languageEnglish
JournalHematology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Fingerprint

Elasticity Imaging Techniques
beta-Thalassemia
Liver Cirrhosis
Ferritins
Iron
Liver
Fibrosis
Logistic Models
Serum
Hepatitis B Antibodies
Iron Overload
Hepatitis C
Odds Ratio

Keywords

  • Beta thalassemia major
  • iron overload
  • liver fibrosis
  • risk factors
  • ultrasound

ASJC Scopus subject areas

  • Hematology

Cite this

Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography. / Al-Khabori, Murtadha; Daar, Shahina; Al-Busafi, Said; AL-Dhuhli, Humoud; Alumairi, Al Ghalya A.; Hassan, Moez; Al-Rahbi, Sara; Al-Ajmi, Umaima.

In: Hematology, 01.01.2018.

Research output: Contribution to journalArticle

@article{d700afe2c7a04c988dcb229e70103b10,
title = "Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography",
abstract = "Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38{\%} and 1{\%} of the patients respectively. The proportion of patients with significant fibrosis was 60{\%}. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.",
keywords = "Beta thalassemia major, iron overload, liver fibrosis, risk factors, ultrasound",
author = "Murtadha Al-Khabori and Shahina Daar and Said Al-Busafi and Humoud AL-Dhuhli and Alumairi, {Al Ghalya A.} and Moez Hassan and Sara Al-Rahbi and Umaima Al-Ajmi",
year = "2018",
month = "1",
day = "1",
doi = "10.1080/10245332.2018.1540518",
language = "English",
journal = "Hematology",
issn = "1024-5332",
publisher = "Taylor and Francis Ltd.",

}

TY - JOUR

T1 - Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography

AU - Al-Khabori, Murtadha

AU - Daar, Shahina

AU - Al-Busafi, Said

AU - AL-Dhuhli, Humoud

AU - Alumairi, Al Ghalya A.

AU - Hassan, Moez

AU - Al-Rahbi, Sara

AU - Al-Ajmi, Umaima

PY - 2018/1/1

Y1 - 2018/1/1

N2 - Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.

AB - Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.

KW - Beta thalassemia major

KW - iron overload

KW - liver fibrosis

KW - risk factors

KW - ultrasound

UR - http://www.scopus.com/inward/record.url?scp=85057176032&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85057176032&partnerID=8YFLogxK

U2 - 10.1080/10245332.2018.1540518

DO - 10.1080/10245332.2018.1540518

M3 - Article

C2 - 30453843

AN - SCOPUS:85057176032

JO - Hematology

JF - Hematology

SN - 1024-5332

ER -