Abstract
Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.
Original language | English |
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Pages (from-to) | 183-188 |
Number of pages | 6 |
Journal | Hematology |
Volume | 24 |
Issue number | 1 |
DOIs | |
Publication status | Published - Jan 1 2019 |
Keywords
- Beta thalassemia major
- iron overload
- liver fibrosis
- risk factors
- ultrasound
ASJC Scopus subject areas
- Hematology