Noninvasive assessment and risk factors of liver fibrosis in patients with thalassemia major using shear wave elastography

Murtadha Al-Khabori, Shahina Daar, Said Al-Busafi, Humoud AL-Dhuhli, Al Ghalya A. Alumairi, Moez Hassan, Sara Al-Rahbi, Umaima Al-Ajmi

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Objectives: This study aimed to estimate the prevalence of liver fibrosis and assess the risk factors for developing significant liver fibrosis in patients with Thalassemia Major (TM). Methods: All patients with TM over the age of 10 years were included in the study. Results: A total of 94 eligible patients underwent 2-D SWE. The median age was 26.7 years. The median of the average 5-year serum ferritin (5yrSF) and liver iron concentration (LIC) assessed by MRI T2* were 1326 µg/L and 6.7 mg/g dw, respectively. Hepatitis C and hepatitis B core antibodies were positive in 38% and 1% of the patients respectively. The proportion of patients with significant fibrosis was 60%. Male gender increased the risk of significant fibrosis (Odds ratio of 0.4; p =.0373). Additionally, the 5yrSF (p =.00661), the LIC (p =.0225) and the lowest LIC of the previous 5 years (p =.0211) were significant. In the multivariable logistic regression model, only 5yrSF (p =.0035) and gender (p =.00984) remained significant. Conclusions: The risk of liver fibrosis is associated with iron overload and gender in patients with TM.

Original languageEnglish
JournalHematology
DOIs
Publication statusAccepted/In press - Jan 1 2018

Keywords

  • Beta thalassemia major
  • iron overload
  • liver fibrosis
  • risk factors
  • ultrasound

ASJC Scopus subject areas

  • Hematology

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