Necrotizing vacuolar myopathy presenting with recurrent myoglobinuria

Ramachandiran Nandhagopal*, Abdullah Al-Asmi, Gujjar R. Arunodaya, P. C. Jacob, Faisal Al-Azri, Clive Harper

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Myoglobinuria occurs in a variety of systemic and neurological disorders and can pose diagnostic challenges. We report on a 23-year-old man in whom recurrent myoglobinuria was observed due to necrotizing vacuolar myopathy confirmed on muscle biopsy. Histopathologically the intramuscular vacuoles lacked the typical findings reported in vacuolar myopathy due to disorders of glycogen and lipid metabolism. We discuss the management approach to recurrent myoglobinuria. Recurrent myoglobinuria in the absence of toxin or drug exposure and seizure is more often due to primary muscle disease. Recognizing the presence of myoglobinuria and the proximate cause is essential in preventing the development of renal dysfunction and the future recurrence of symptoms.

Original languageEnglish
Pages (from-to)784-786
Number of pages3
JournalInternational Journal of Neuroscience
Issue number12
Publication statusPublished - Nov 2010
Externally publishedYes


  • Biopsy
  • Creatine kinase
  • Magnetic resonance imaging
  • Myoglobinuria
  • Myopathy

ASJC Scopus subject areas

  • Neuroscience(all)


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