Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

Majekodunmi O. Fatope; Suad Khamis S Al-Burtomani; John O. Ochei; Abdulrahman O. Abdulnour; Salma M Z Al-Kindy; Yoshio Takeda

doi:10.1016/S0031-9422(02)00686-6

Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

Majekodunmi O. Fatope, Suad Khamis S Al-Burtomani, John O. Ochei, Abdulrahman O. Abdulnour, Salma M Z Al-Kindy, Yoshio Takeda

Chemistry

Research output: Contribution to journal › Article

26 Citations (Scopus)

Abstract

A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, ¹H-¹H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.

Original language	English
Pages (from-to)	1251-1255
Number of pages	5
Journal	Phytochemistry
Volume	62
Issue number	8
DOIs	https://doi.org/10.1016/S0031-9422(02)00686-6
Publication status	Published - Apr 2003

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Keywords

Antifungal activity
Brine shrimp lethality test
Burseraceae
Commiphora wightii
Flavanone
Structure elucidation

ASJC Scopus subject areas

Plant Science
Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery

Cite this

Fatope, M. O., Al-Burtomani, S. K. S., Ochei, J. O., Abdulnour, A. O., Al-Kindy, S. M. Z., & Takeda, Y. (2003). Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii. Phytochemistry, 62(8), 1251-1255. https://doi.org/10.1016/S0031-9422(02)00686-6

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abstract = "A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.",

keywords = "Antifungal activity, Brine shrimp lethality test, Burseraceae, Commiphora wightii, Flavanone, Structure elucidation",

author = "Fatope, {Majekodunmi O.} and Al-Burtomani, {Suad Khamis S} and Ochei, {John O.} and Abdulnour, {Abdulrahman O.} and Al-Kindy, {Salma M Z} and Yoshio Takeda",

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AU - Fatope, Majekodunmi O.

AU - Al-Burtomani, Suad Khamis S

AU - Ochei, John O.

AU - Abdulnour, Abdulrahman O.

AU - Al-Kindy, Salma M Z

AU - Takeda, Yoshio

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KW - Brine shrimp lethality test

KW - Burseraceae

KW - Commiphora wightii

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10.1016/S0031-9422(02)00686-6