Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

Majekodunmi O. Fatope; Suad Khamis S Al-Burtomani; John O. Ochei; Abdulrahman O. Abdulnour; Salma M Z Al-Kindy; Yoshio Takeda

doi:10.1016/S0031-9422(02)00686-6

Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

Majekodunmi O. Fatope^*, Suad Khamis S Al-Burtomani, John O. Ochei, Abdulrahman O. Abdulnour, Salma M Z Al-Kindy, Yoshio Takeda

^*Corresponding author for this work

Chemistry

Research output: Contribution to journal › Article › peer-review

26 Citations (Scopus)

Abstract

A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, ¹H-¹H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.

Original language	English
Pages (from-to)	1251-1255
Number of pages	5
Journal	Phytochemistry
Volume	62
Issue number	8
DOIs	https://doi.org/10.1016/S0031-9422(02)00686-6
Publication status	Published - Apr 2003

Keywords

Antifungal activity
Brine shrimp lethality test
Burseraceae
Commiphora wightii
Flavanone
Structure elucidation

ASJC Scopus subject areas

Plant Science
Biochemistry
Molecular Biology
Organic Chemistry
Drug Discovery

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@article{c17ba00071974dcfa19da2bd35accc3d,

title = "Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii",

abstract = "A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.",

keywords = "Antifungal activity, Brine shrimp lethality test, Burseraceae, Commiphora wightii, Flavanone, Structure elucidation",

author = "Fatope, {Majekodunmi O.} and Al-Burtomani, {Suad Khamis S} and Ochei, {John O.} and Abdulnour, {Abdulrahman O.} and Al-Kindy, {Salma M Z} and Yoshio Takeda",

year = "2003",

month = apr,

doi = "10.1016/S0031-9422(02)00686-6",

language = "English",

volume = "62",

pages = "1251--1255",

journal = "Phytochemistry",

issn = "0031-9422",

publisher = "Elsevier Limited",

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T2 - A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

AU - Fatope, Majekodunmi O.

AU - Al-Burtomani, Suad Khamis S

AU - Ochei, John O.

AU - Abdulnour, Abdulrahman O.

AU - Al-Kindy, Salma M Z

AU - Takeda, Yoshio

PY - 2003/4

Y1 - 2003/4

N2 - A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.

AB - A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.

KW - Antifungal activity

KW - Brine shrimp lethality test

KW - Burseraceae

KW - Commiphora wightii

KW - Flavanone

KW - Structure elucidation

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