Muscanone: A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii

Majekodunmi O. Fatope, Suad Khamis S Al-Burtomani, John O. Ochei, Abdulrahman O. Abdulnour, Salma M Z Al-Kindy, Yoshio Takeda

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26 Citations (Scopus)

Abstract

A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.

Original languageEnglish
Pages (from-to)1251-1255
Number of pages5
JournalPhytochemistry
Volume62
Issue number8
DOIs
Publication statusPublished - Apr 2003

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Keywords

  • Antifungal activity
  • Brine shrimp lethality test
  • Burseraceae
  • Commiphora wightii
  • Flavanone
  • Structure elucidation

ASJC Scopus subject areas

  • Plant Science
  • Biochemistry
  • Molecular Biology
  • Organic Chemistry
  • Drug Discovery

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