Abstract
A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.
| Original language | English |
|---|---|
| Pages (from-to) | 1251-1255 |
| Number of pages | 5 |
| Journal | Phytochemistry |
| Volume | 62 |
| Issue number | 8 |
| DOIs | |
| Publication status | Published - Apr 2003 |
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Keywords
- Antifungal activity
- Brine shrimp lethality test
- Burseraceae
- Commiphora wightii
- Flavanone
- Structure elucidation
ASJC Scopus subject areas
- Plant Science
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery
Cite this
Muscanone : A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii. / Fatope, Majekodunmi O.; Al-Burtomani, Suad Khamis S; Ochei, John O.; Abdulnour, Abdulrahman O.; Al-Kindy, Salma M Z; Takeda, Yoshio.
In: Phytochemistry, Vol. 62, No. 8, 04.2003, p. 1251-1255.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Muscanone
T2 - A 3-O-(1″, 8″, 14″-trimethylhexadecanyl)naringenin from Commiphora wightii
AU - Fatope, Majekodunmi O.
AU - Al-Burtomani, Suad Khamis S
AU - Ochei, John O.
AU - Abdulnour, Abdulrahman O.
AU - Al-Kindy, Salma M Z
AU - Takeda, Yoshio
PY - 2003/4
Y1 - 2003/4
N2 - A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.
AB - A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.
KW - Antifungal activity
KW - Brine shrimp lethality test
KW - Burseraceae
KW - Commiphora wightii
KW - Flavanone
KW - Structure elucidation
UR - http://www.scopus.com/inward/record.url?scp=0037381714&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0037381714&partnerID=8YFLogxK
U2 - 10.1016/S0031-9422(02)00686-6
DO - 10.1016/S0031-9422(02)00686-6
M3 - Article
C2 - 12648547
AN - SCOPUS:0037381714
VL - 62
SP - 1251
EP - 1255
JO - Phytochemistry
JF - Phytochemistry
SN - 0031-9422
IS - 8
ER -