Abstract
A new antifungal flavanone, muscanone (1), was isolated along with known naringenin (2) from Commiphora wightii (Arn.) Bhandari (Burseraceae) by directing the fractionation of an EtOH extract of the air-dried trunk of C. wightii with microbial sensitivity assay. The structures of 1 and 2 were determined from EIMS, HREIMS, DEPT, 1H-1H COSY, HSQC and HMBC spectral data. Muscanone (1) was identified as 3-O-(1″, 8″,14″-trimethylhexadecanyl)naringenin and was found to be active against Candida albicans. The isolation, structure elucidation, NMR spectral assignments, and bioactivities of 1 and 2 are reported.
Original language | English |
---|---|
Pages (from-to) | 1251-1255 |
Number of pages | 5 |
Journal | Phytochemistry |
Volume | 62 |
Issue number | 8 |
DOIs | |
Publication status | Published - Apr 2003 |
Keywords
- Antifungal activity
- Brine shrimp lethality test
- Burseraceae
- Commiphora wightii
- Flavanone
- Structure elucidation
ASJC Scopus subject areas
- Plant Science
- Biochemistry
- Molecular Biology
- Organic Chemistry
- Drug Discovery