TY - JOUR
T1 - Motor and behavioral changes in rats with adenine-induced chronic renal failure
T2 - Influence of acacia gum treatment
AU - Ali, Badreldin H.
AU - Ziada, Amal
AU - Al Husseni, Isehaq
AU - Beegam, Sumaya
AU - Nemmar, Abderrahim
N1 - Funding Information:
The Research Council of Sultan Qaboos University provided financial support for the work (RC/MED/PHAR/10/01). We thank the staff of the SQU Small Animal House for looking after the rats, and Professor S Adawi for reading the manuscript.
PY - 2011/1
Y1 - 2011/1
N2 - Chronic renal failure (CRF) either occurring naturally in humans or induced surgically in rats causes alterations in behavior andmotor functions. However, the effect of chemically induced CRF in rats on behavior is not known. We induced CRF in rats by feeding adenine (0.75% w/w, four weeks) and investigated the effect of the ensuing CRF on a depression model (forced swimming test, FST), analgesia (mechanical nociception), neuromuscular coordination (Rota-rod test) and motor activity (activity meter test). Further, we investigated the effect of giving acacia gum (AG, 10% w/v) in the drinking water concomitantly with adenine using the above models. AG has been previously shown to ameliorate the severity of CRF in humans and rats. Adenine-induced CRF significantly increased the plasma concentrations of urea and creatinine, and reduced creatinine clearance. Additionally, it significantly reduced motor activity and increased immobility time in the FST, suggesting a depressant-like effect. Both of these actions were significantly antagonized by AG treatment. Adenine insignificantly reduced the mechanical nociceptive threshold by 15%. The results of the tests for neuromuscular coordination were inconclusive. In conclusion, adenine-induced CRF caused motor and behavioral alterations, and these were significantly mitigated by administration of AG.
AB - Chronic renal failure (CRF) either occurring naturally in humans or induced surgically in rats causes alterations in behavior andmotor functions. However, the effect of chemically induced CRF in rats on behavior is not known. We induced CRF in rats by feeding adenine (0.75% w/w, four weeks) and investigated the effect of the ensuing CRF on a depression model (forced swimming test, FST), analgesia (mechanical nociception), neuromuscular coordination (Rota-rod test) and motor activity (activity meter test). Further, we investigated the effect of giving acacia gum (AG, 10% w/v) in the drinking water concomitantly with adenine using the above models. AG has been previously shown to ameliorate the severity of CRF in humans and rats. Adenine-induced CRF significantly increased the plasma concentrations of urea and creatinine, and reduced creatinine clearance. Additionally, it significantly reduced motor activity and increased immobility time in the FST, suggesting a depressant-like effect. Both of these actions were significantly antagonized by AG treatment. Adenine insignificantly reduced the mechanical nociceptive threshold by 15%. The results of the tests for neuromuscular coordination were inconclusive. In conclusion, adenine-induced CRF caused motor and behavioral alterations, and these were significantly mitigated by administration of AG.
KW - Acacia gum
KW - Adenine
KW - Behavior
KW - Chronic renal failure
KW - Rats
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U2 - 10.1258/ebm.2010.010163
DO - 10.1258/ebm.2010.010163
M3 - Article
C2 - 21239740
AN - SCOPUS:78751537318
SN - 1535-3702
VL - 236
SP - 107
EP - 112
JO - Experimental Biology and Medicine
JF - Experimental Biology and Medicine
IS - 1
ER -