Abstract
The aim of this study was to investigate whether the hypotensive effect of rat α‐calcitonin gene‐related peptide (αCGRP) in conscious rats is mediated by endothelium‐derived nitric oxide (NO) or the opening of adenosine 5′‐triphosphate (ATP)‐sensitive potassium (KATP) channels. Dose‐mean arterial pressure (MAP)‐response curves of αCGRP were examined in the presence of vehicle, phenylephrine, KATP channel antagonist glibenclamide or NO synthase inhibitors, NG‐nitro‐l‐arginine methyl ester (l‐NAME) and NG‐nitro‐d‐arginine methyl ester (d‐NAME). Dose‐MAP‐response curves for sodium nitroprusside were also constructed in the presence and absence of l‐NAME and d‐NAME. αCGRP and nitroprusside produced dose‐dependent reductions in MAP which were potentiated by phenylephrine. Both l‐NAME and d‐NAME attenuated the depressor response to αCGRP but not nitroprusside. Dose‐MAP‐response curves for pinacidil, a KATP‐channel activator, were also examined in the presence of glibenclamide or vehicle. Glibenclamide attenuated pinacidil‐ but not αCGRP‐induced reductions in MAP. It is concluded that the hypotensive effects of αCGRP are partially mediated via endothelium‐derived NO but not via the opening of KATP channels. 1992 British Pharmacological Society
| Original language | English |
|---|---|
| Pages (from-to) | 45-48 |
| Number of pages | 4 |
| Journal | British Journal of Pharmacology |
| Volume | 106 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 1992 |
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Keywords
- Calcitonin gene‐related peptide (CGRP)
- glibenclamide
- K channel
- N‐nitro‐d‐arginine methyl ester (d‐NAME)
- N‐nitro‐l‐arginine methyl ester (l‐NAME)
- nitric oxide synthase inhibitor
- nitroprusside
- pinacidil
ASJC Scopus subject areas
- Pharmacology
Cite this
Mechanism of the vasodilator action of calcitonin gene‐related peptide in conscious rats. / Abdelrahman, Aly; Wang, Yong‐Xiang ‐X; Chang, Sylvia Diana; Pang, Catherine C.Y.
In: British Journal of Pharmacology, Vol. 106, No. 1, 1992, p. 45-48.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Mechanism of the vasodilator action of calcitonin gene‐related peptide in conscious rats
AU - Abdelrahman, Aly
AU - Wang, Yong‐Xiang ‐X
AU - Chang, Sylvia Diana
AU - Pang, Catherine C.Y.
PY - 1992
Y1 - 1992
N2 - The aim of this study was to investigate whether the hypotensive effect of rat α‐calcitonin gene‐related peptide (αCGRP) in conscious rats is mediated by endothelium‐derived nitric oxide (NO) or the opening of adenosine 5′‐triphosphate (ATP)‐sensitive potassium (KATP) channels. Dose‐mean arterial pressure (MAP)‐response curves of αCGRP were examined in the presence of vehicle, phenylephrine, KATP channel antagonist glibenclamide or NO synthase inhibitors, NG‐nitro‐l‐arginine methyl ester (l‐NAME) and NG‐nitro‐d‐arginine methyl ester (d‐NAME). Dose‐MAP‐response curves for sodium nitroprusside were also constructed in the presence and absence of l‐NAME and d‐NAME. αCGRP and nitroprusside produced dose‐dependent reductions in MAP which were potentiated by phenylephrine. Both l‐NAME and d‐NAME attenuated the depressor response to αCGRP but not nitroprusside. Dose‐MAP‐response curves for pinacidil, a KATP‐channel activator, were also examined in the presence of glibenclamide or vehicle. Glibenclamide attenuated pinacidil‐ but not αCGRP‐induced reductions in MAP. It is concluded that the hypotensive effects of αCGRP are partially mediated via endothelium‐derived NO but not via the opening of KATP channels. 1992 British Pharmacological Society
AB - The aim of this study was to investigate whether the hypotensive effect of rat α‐calcitonin gene‐related peptide (αCGRP) in conscious rats is mediated by endothelium‐derived nitric oxide (NO) or the opening of adenosine 5′‐triphosphate (ATP)‐sensitive potassium (KATP) channels. Dose‐mean arterial pressure (MAP)‐response curves of αCGRP were examined in the presence of vehicle, phenylephrine, KATP channel antagonist glibenclamide or NO synthase inhibitors, NG‐nitro‐l‐arginine methyl ester (l‐NAME) and NG‐nitro‐d‐arginine methyl ester (d‐NAME). Dose‐MAP‐response curves for sodium nitroprusside were also constructed in the presence and absence of l‐NAME and d‐NAME. αCGRP and nitroprusside produced dose‐dependent reductions in MAP which were potentiated by phenylephrine. Both l‐NAME and d‐NAME attenuated the depressor response to αCGRP but not nitroprusside. Dose‐MAP‐response curves for pinacidil, a KATP‐channel activator, were also examined in the presence of glibenclamide or vehicle. Glibenclamide attenuated pinacidil‐ but not αCGRP‐induced reductions in MAP. It is concluded that the hypotensive effects of αCGRP are partially mediated via endothelium‐derived NO but not via the opening of KATP channels. 1992 British Pharmacological Society
KW - Calcitonin gene‐related peptide (CGRP)
KW - glibenclamide
KW - K channel
KW - N‐nitro‐d‐arginine methyl ester (d‐NAME)
KW - N‐nitro‐l‐arginine methyl ester (l‐NAME)
KW - nitric oxide synthase inhibitor
KW - nitroprusside
KW - pinacidil
UR - http://www.scopus.com/inward/record.url?scp=0026511037&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0026511037&partnerID=8YFLogxK
U2 - 10.1111/j.1476-5381.1992.tb14290.x
DO - 10.1111/j.1476-5381.1992.tb14290.x
M3 - Article
VL - 106
SP - 45
EP - 48
JO - British Journal of Pharmacology
JF - British Journal of Pharmacology
SN - 0007-1188
IS - 1
ER -