Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

M. O.M. Tanira; B. H. Ali; A. K. Bashir; S. Dhanasekaran; E. M. Tibiricá; L. M. Alves

doi:10.1006/phrs.1999.0598

Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

M. O.M. Tanira^*, B. H. Ali, A. K. Bashir, S. Dhanasekaran, E. M. Tibiricá, L. M. Alves

^*Corresponding author for this work

Pharmacology & Clinical Pharmacy

Research output: Contribution to journal › Article › peer-review

10 Citations (Scopus)

Abstract

The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal^-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal^-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal^-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

Original language	English
Pages (from-to)	369-378
Number of pages	10
Journal	Pharmacological Research
Volume	41
Issue number	3
DOIs	https://doi.org/10.1006/phrs.1999.0598
Publication status	Published - 2000

Keywords

Central
Hypotensive
Intracerebroventricular (icv)
Pithed
Rat
Rhazya stricta

ASJC Scopus subject areas

Pharmacology

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10.1006/phrs.1999.0598

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title = "Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats",

abstract = "The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.",

keywords = "Central, Hypotensive, Intracerebroventricular (icv), Pithed, Rat, Rhazya stricta",

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AU - Tanira, M. O.M.

AU - Ali, B. H.

AU - Bashir, A. K.

AU - Dhanasekaran, S.

AU - Tibiricá, E. M.

AU - Alves, L. M.

PY - 2000

Y1 - 2000

N2 - The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

AB - The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

KW - Central

KW - Hypotensive

KW - Intracerebroventricular (icv)

KW - Pithed

KW - Rat

KW - Rhazya stricta

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ER -

Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

Abstract

Keywords

ASJC Scopus subject areas

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