Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

M. O M Tanira, B. H. Ali, A. K. Bashir, S. Dhanasekaran, E. M. Tibiricá, L. M. Alves

Research output: Contribution to journalArticle

10 Citations (Scopus)

Abstract

The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalPharmacological Research
Volume41
Issue number3
DOIs
Publication statusPublished - 2000

Keywords

  • Central
  • Hypotensive
  • Intracerebroventricular (icv)
  • Pithed
  • Rat
  • Rhazya stricta

ASJC Scopus subject areas

  • Pharmacology

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