Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats

M. O M Tanira, B. H. Ali, A. K. Bashir, S. Dhanasekaran, E. M. Tibiricá, L. M. Alves

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The hypotensive action of Rhazya stricta lyophilized leaf extract was found to be partly caused by the electrolyte content of the extract, and partly caused by a strongly basic alkaloidal fraction (AF). AF (0.05-1.6 mg animal-1) caused a dose-dependent reduction in mean arterial blood pressure (MAP) of urethane-anaesthetized rat preparations. In naive pithed rats, AF administration (0.5-2.0 mg animal-1) significantly increased MAP. In pithed or spinalized rats made normotensive by noradrenaline infusion, AF (0.25 mg animal-1) did not cause any significant changes. Direct intracerebroventricular injection of AF (0.1-0.4 mg) markedly and significantly reduced MAP. It is suggested that the hypotensive action of AF to be mediated by a central mechanism. (C) 2000 Academic Press.

Original languageEnglish
Pages (from-to)369-378
Number of pages10
JournalPharmacological Research
Volume41
Issue number3
DOIs
Publication statusPublished - 2000

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Apocynaceae
Arterial Pressure
Urethane
Electrolytes
Norepinephrine
Injections

Keywords

  • Central
  • Hypotensive
  • Intracerebroventricular (icv)
  • Pithed
  • Rat
  • Rhazya stricta

ASJC Scopus subject areas

  • Pharmacology

Cite this

Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats. / Tanira, M. O M; Ali, B. H.; Bashir, A. K.; Dhanasekaran, S.; Tibiricá, E. M.; Alves, L. M.

In: Pharmacological Research, Vol. 41, No. 3, 2000, p. 369-378.

Research output: Contribution to journalArticle

Tanira, M. O M ; Ali, B. H. ; Bashir, A. K. ; Dhanasekaran, S. ; Tibiricá, E. M. ; Alves, L. M. / Mechanism of the hypotensive action of Rhazya stricta leaf extract in rats. In: Pharmacological Research. 2000 ; Vol. 41, No. 3. pp. 369-378.
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