Maternal complications and the association with baseline variables in pregnant women with sickle cell disease

Sharifa H. Al-Farsi, Nihal M. Al-Riyami, Murtadha K. Al-Khabori, Mohammed N. Al-Hunaini

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Sickle cell disease is an inherited hemoglobinopathy with multi system complications. It has been associated with multiple maternal complications. A retrospective review of 68 consecutive pregnant women with sickle cell disease, followed in a tertiary center, was conducted over 5 years, to estimate the incidence of different maternal complications and the impact of baseline characteristics. Sixty-eight patients were analyzed (mean age 30 years). Sixty-two patients had a Hb SS genotype. The initial mean hemoglobin (Hb) level was 9.5 g/dL. Twelve patients delivered by Cesarean section. Sixty-five patients required admission for sickle cell disease/pregnancy-related complications [96.0%; 95% confidence interval (95% CI) 91-100]. Infection was seen in 17 patients (25.0%, 95% CI 14-36). Blood transfusions were given to 61 patients (90.0%, 95% CI 82-97). Eight patients had gestational hypertension (18.0%, 95% CI 4-20), while five patients (7.0%, 95% CI 1-14) had pre term labor. One patient developed eclampsia and one had a uterine rupture. One patient died due to post partum hemorrhage. The multi variable logistic regression model on the impact on the major maternal complications revealed none of the baseline factors to be statistically significant. Sickle cell disease patients have low mortality and pregnancy-related morbidity but high sickle cell disease-related morbidity. Prospective studies are needed to confirm these results.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalHemoglobin
Volume37
Issue number3
DOIs
Publication statusPublished - 2013

Fingerprint

Sickle Cell Anemia
Pregnant Women
Mothers
Confidence Intervals
Sickle Hemoglobin
Logistics
Hemoglobins
Blood
Logistic Models
Personnel
Uterine Rupture
Morbidity
Hemoglobinopathies
Pregnancy Induced Hypertension
Eclampsia
Pregnancy Complications
Patient Admission
Cesarean Section
Blood Transfusion
Genotype

Keywords

  • Complications
  • Pregnancy
  • Sickle cell disease

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Cite this

Maternal complications and the association with baseline variables in pregnant women with sickle cell disease. / Al-Farsi, Sharifa H.; Al-Riyami, Nihal M.; Al-Khabori, Murtadha K.; Al-Hunaini, Mohammed N.

In: Hemoglobin, Vol. 37, No. 3, 2013, p. 219-226.

Research output: Contribution to journalArticle

@article{17ed0645e88048478b6975209f1705bc,
title = "Maternal complications and the association with baseline variables in pregnant women with sickle cell disease",
abstract = "Sickle cell disease is an inherited hemoglobinopathy with multi system complications. It has been associated with multiple maternal complications. A retrospective review of 68 consecutive pregnant women with sickle cell disease, followed in a tertiary center, was conducted over 5 years, to estimate the incidence of different maternal complications and the impact of baseline characteristics. Sixty-eight patients were analyzed (mean age 30 years). Sixty-two patients had a Hb SS genotype. The initial mean hemoglobin (Hb) level was 9.5 g/dL. Twelve patients delivered by Cesarean section. Sixty-five patients required admission for sickle cell disease/pregnancy-related complications [96.0{\%}; 95{\%} confidence interval (95{\%} CI) 91-100]. Infection was seen in 17 patients (25.0{\%}, 95{\%} CI 14-36). Blood transfusions were given to 61 patients (90.0{\%}, 95{\%} CI 82-97). Eight patients had gestational hypertension (18.0{\%}, 95{\%} CI 4-20), while five patients (7.0{\%}, 95{\%} CI 1-14) had pre term labor. One patient developed eclampsia and one had a uterine rupture. One patient died due to post partum hemorrhage. The multi variable logistic regression model on the impact on the major maternal complications revealed none of the baseline factors to be statistically significant. Sickle cell disease patients have low mortality and pregnancy-related morbidity but high sickle cell disease-related morbidity. Prospective studies are needed to confirm these results.",
keywords = "Complications, Pregnancy, Sickle cell disease",
author = "Al-Farsi, {Sharifa H.} and Al-Riyami, {Nihal M.} and Al-Khabori, {Murtadha K.} and Al-Hunaini, {Mohammed N.}",
year = "2013",
doi = "10.3109/03630269.2013.780249",
language = "English",
volume = "37",
pages = "219--226",
journal = "Hemoglobin",
issn = "0363-0269",
publisher = "Informa Healthcare",
number = "3",

}

TY - JOUR

T1 - Maternal complications and the association with baseline variables in pregnant women with sickle cell disease

AU - Al-Farsi, Sharifa H.

AU - Al-Riyami, Nihal M.

AU - Al-Khabori, Murtadha K.

AU - Al-Hunaini, Mohammed N.

PY - 2013

Y1 - 2013

N2 - Sickle cell disease is an inherited hemoglobinopathy with multi system complications. It has been associated with multiple maternal complications. A retrospective review of 68 consecutive pregnant women with sickle cell disease, followed in a tertiary center, was conducted over 5 years, to estimate the incidence of different maternal complications and the impact of baseline characteristics. Sixty-eight patients were analyzed (mean age 30 years). Sixty-two patients had a Hb SS genotype. The initial mean hemoglobin (Hb) level was 9.5 g/dL. Twelve patients delivered by Cesarean section. Sixty-five patients required admission for sickle cell disease/pregnancy-related complications [96.0%; 95% confidence interval (95% CI) 91-100]. Infection was seen in 17 patients (25.0%, 95% CI 14-36). Blood transfusions were given to 61 patients (90.0%, 95% CI 82-97). Eight patients had gestational hypertension (18.0%, 95% CI 4-20), while five patients (7.0%, 95% CI 1-14) had pre term labor. One patient developed eclampsia and one had a uterine rupture. One patient died due to post partum hemorrhage. The multi variable logistic regression model on the impact on the major maternal complications revealed none of the baseline factors to be statistically significant. Sickle cell disease patients have low mortality and pregnancy-related morbidity but high sickle cell disease-related morbidity. Prospective studies are needed to confirm these results.

AB - Sickle cell disease is an inherited hemoglobinopathy with multi system complications. It has been associated with multiple maternal complications. A retrospective review of 68 consecutive pregnant women with sickle cell disease, followed in a tertiary center, was conducted over 5 years, to estimate the incidence of different maternal complications and the impact of baseline characteristics. Sixty-eight patients were analyzed (mean age 30 years). Sixty-two patients had a Hb SS genotype. The initial mean hemoglobin (Hb) level was 9.5 g/dL. Twelve patients delivered by Cesarean section. Sixty-five patients required admission for sickle cell disease/pregnancy-related complications [96.0%; 95% confidence interval (95% CI) 91-100]. Infection was seen in 17 patients (25.0%, 95% CI 14-36). Blood transfusions were given to 61 patients (90.0%, 95% CI 82-97). Eight patients had gestational hypertension (18.0%, 95% CI 4-20), while five patients (7.0%, 95% CI 1-14) had pre term labor. One patient developed eclampsia and one had a uterine rupture. One patient died due to post partum hemorrhage. The multi variable logistic regression model on the impact on the major maternal complications revealed none of the baseline factors to be statistically significant. Sickle cell disease patients have low mortality and pregnancy-related morbidity but high sickle cell disease-related morbidity. Prospective studies are needed to confirm these results.

KW - Complications

KW - Pregnancy

KW - Sickle cell disease

UR - http://www.scopus.com/inward/record.url?scp=84877838347&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=84877838347&partnerID=8YFLogxK

U2 - 10.3109/03630269.2013.780249

DO - 10.3109/03630269.2013.780249

M3 - Article

C2 - 23590330

AN - SCOPUS:84877838347

VL - 37

SP - 219

EP - 226

JO - Hemoglobin

JF - Hemoglobin

SN - 0363-0269

IS - 3

ER -