Maternal complications and the association with baseline variables in pregnant women with sickle cell disease

Sharifa H. Al-Farsi, Nihal M. Al-Riyami, Murtadha K. Al-Khabori, Mohammed N. Al-Hunaini

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Sickle cell disease is an inherited hemoglobinopathy with multi system complications. It has been associated with multiple maternal complications. A retrospective review of 68 consecutive pregnant women with sickle cell disease, followed in a tertiary center, was conducted over 5 years, to estimate the incidence of different maternal complications and the impact of baseline characteristics. Sixty-eight patients were analyzed (mean age 30 years). Sixty-two patients had a Hb SS genotype. The initial mean hemoglobin (Hb) level was 9.5 g/dL. Twelve patients delivered by Cesarean section. Sixty-five patients required admission for sickle cell disease/pregnancy-related complications [96.0%; 95% confidence interval (95% CI) 91-100]. Infection was seen in 17 patients (25.0%, 95% CI 14-36). Blood transfusions were given to 61 patients (90.0%, 95% CI 82-97). Eight patients had gestational hypertension (18.0%, 95% CI 4-20), while five patients (7.0%, 95% CI 1-14) had pre term labor. One patient developed eclampsia and one had a uterine rupture. One patient died due to post partum hemorrhage. The multi variable logistic regression model on the impact on the major maternal complications revealed none of the baseline factors to be statistically significant. Sickle cell disease patients have low mortality and pregnancy-related morbidity but high sickle cell disease-related morbidity. Prospective studies are needed to confirm these results.

Original languageEnglish
Pages (from-to)219-226
Number of pages8
JournalHemoglobin
Volume37
Issue number3
DOIs
Publication statusPublished - 2013

Keywords

  • Complications
  • Pregnancy
  • Sickle cell disease

ASJC Scopus subject areas

  • Hematology
  • Genetics(clinical)
  • Clinical Biochemistry
  • Biochemistry, medical

Fingerprint Dive into the research topics of 'Maternal complications and the association with baseline variables in pregnant women with sickle cell disease'. Together they form a unique fingerprint.

  • Cite this