Malignant transformations in Ovarian Teratomas: A report of four cases

Abdul Hannan, Umm e Kalsoom Awan, Neelam Siddiqui, Narjis Muzaffar

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Mature cystic teratoma (MCT) is a common ovarian neoplasm in young females. A secondary malignant transformation occurs rarely in cystic teratomas at an older age. These secondary malignant neoplasms most commonly are squamous cell carcinomas (SCCs). Various mechanisms are reported, but the exact aetiology is unknown. We report three cases of SCC arising in cystic teratoma and one case of papillary thyroid neoplasm as secondary transformation. The SCCs were arising from the cyst wall, while the papillary thyroid malignancy arose from the normal-looking thyroid epithelium. Histologically, all SCC cases were poorly differentiated. Poor prognostic features for secondary transformations include size more than 10cm, older age and rapid growth. Data is scarce regarding their appropriate treatment. However, surgical debulking is necessary. Platinum-based adjuvant regimens and taxanes are recommended in cases of advanced disease. In this paper we review and share our experience with this rare disorder.

Original languageEnglish
Pages (from-to)946-948
Number of pages3
JournalJournal of the Pakistan Medical Association
Volume64
Issue number8
Publication statusPublished - 2014

Keywords

  • Cystic
  • Malignant
  • Papillary
  • Squamous
  • Teratoma

ASJC Scopus subject areas

  • Medicine(all)

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