Low nourishment of B-vitamins is associated with hyperhomocysteinemia and oxidative stress in newly diagnosed cardiac patients

Mostafa I. Waly, Amanat Ali, Amira Al-Nassri, Mohamed Al-Mukhaini, John Valliatte, Yahya Al-Farsi

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

We are currently witnessing a dramatic change in lifestyle and food choices that is accompanied with an increase in the rate of morbidity and mortality from cardiovascular diseases (CVD). Although studies have reported an association of CVD with hyperhomocysteinemia-mediated oxidative stress, the biochemical basis is not known. This case–control study was aimed to evaluate the nutritional and biochemical status of B-vitamins in relation to hyperhomocysteinemia and oxidative stress in newly diagnosed cardiac patients. The retrospective dietary intake of the study subjects (cases and controls) was estimated using a semi-quantitative food frequency questionnaire, and fasting blood samples were drawn to assess their serum levels of B-vitamins (folate, vitamins B6 and B12), homocysteine (HCY), and oxidative stress indices such as glutathione (GSH), total antioxidant capacity (TAC), malondialdehyde (MDA), and nitrites and nitrates (NN). It was observed that the cases had a lower dietary intake of B-vitamins as compared to their matched control subjects as well as to the corresponding recommended dietary allowances. Biochemical analysis of cases, as compared to controls, indicated depletion of GSH, impairment of TAC, and an elevation in the serum levels of HCY, MDA, and NN. These results suggest that lower status (dietary intake and serum levels) of B-vitamins is involved in the etiology of hyperhomocysteinemia and oxidative stress, the typical risk factors for CVD.

Original languageEnglish
Pages (from-to)46-51
Number of pages6
JournalExperimental Biology and Medicine
Volume241
Issue number1
DOIs
Publication statusPublished - Jan 1 2016

Fingerprint

Vitamin B Complex
Hyperhomocysteinemia
Oxidative stress
Oxidative Stress
Cardiovascular Diseases
Homocysteine
Nitrites
Malondialdehyde
Nitrates
Antioxidants
Serum
Recommended Dietary Allowances
Food
Vitamin B 6
Vitamin B 12
Nutritional Status
Folic Acid
Glutathione
Case-Control Studies
Life Style

Keywords

  • cardiac patients
  • Folic acid
  • hyperhomocysteinemia
  • oxidative stress
  • vitamin B
  • vitamin B

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Low nourishment of B-vitamins is associated with hyperhomocysteinemia and oxidative stress in newly diagnosed cardiac patients. / Waly, Mostafa I.; Ali, Amanat; Al-Nassri, Amira; Al-Mukhaini, Mohamed; Valliatte, John; Al-Farsi, Yahya.

In: Experimental Biology and Medicine, Vol. 241, No. 1, 01.01.2016, p. 46-51.

Research output: Contribution to journalArticle

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